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{{Infobox_gene}}
{{PBB_Controls
'''Ribosome biogenesis protein BOP1''' is a [[protein]] that in humans is encoded by the ''BOP1'' [[gene]].<ref name="pmid8590280">{{cite journal | vauthors = Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N | title = Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Res | volume = 2 | issue = 4 | pages = 167–74, 199–210 | date = Mar 1996 | pmid = 8590280 | pmc = | doi = 10.1093/dnares/2.4.167 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BOP1 block of proliferation 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23246| accessdate = }}</ref>
| update_page = yes
 
| require_manual_inspection = no
== Function ==
| update_protein_box = yes
 
| update_summary = yes
It is a [[WD40 repeat]]-containing [[nucleolus|nucleolar]] protein involved in rRNA processing, thereby controlling the [[Cell (biology)|cell]] cycle.<ref name="pmid16362343">{{cite journal | vauthors = Kim J, Goo SY, Chung HJ, Yang HW, Yong TS, Lee KH, Park SJ | title = Interaction of beta-giardin with the Bop1 protein in Giardia lamblia | journal = Parasitol. Res. | volume = 98 | issue = 2 | pages = 138–44 | date = January 2006 | pmid = 16362343 | doi = 10.1007/s00436-005-0040-8 | url = }}</ref> It is required for the maturation of the 25S and 5.8S [[rRNA|ribosomal]] RNAs. It may serve as an essential factor in [[ribosome]] formation that coordinates processing of the spacer regions in pre-rRNA. The Pes1-Bop1 [[Protein complex|complex]] has several components: BOP1, [[GRWD1]], [[PES1]], [[ORC6L]], and [[RPL3]] and is involved in ribosome [[biogenesis]] and altered [[chromosome segregation]]. The overexpression of BOP1 increases the percentage of [[multipolar spindles]] in [[human cell]]s. Deregulation of the BOP1 pathway may contribute to colorectal tumourigenesis in [[Homo sapiens|human]]s.<ref name="pmid16804918">{{cite journal | vauthors = Killian A, Sarafan-Vasseur N, Sesboüé R, Le Pessot F, Blanchard F, Lamy A, Laurent M, Flaman JM, Frébourg T | title = Contribution of the BOP1 gene, located on 8q24, to colorectal tumorigenesis | journal = Genes Chromosomes Cancer | volume = 45 | issue = 9 | pages = 874–81 | date = September 2006 | pmid = 16804918 | doi = 10.1002/gcc.20351 | url = }}</ref> Elevated levels of Bop1 induces Bop1/WDR12 and Bop1/Pes1 subcomplexes and the assembly and integrity of the PeBoW complex is highly sensitive to changes in Bop1 protein levels.<ref name="pmid17353269">{{cite journal | vauthors = Rohrmoser M, Hölzel M, Grimm T, Malamoussi A, Harasim T, Orban M, Pfisterer I, Gruber-Eber A, Kremmer E, Eick D | title = Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit | journal = Mol. Cell. Biol. | volume = 27 | issue = 10 | pages = 3682–94 | date = May 2007 | pmid = 17353269 | pmc = 1899993 | doi = 10.1128/MCB.00172-07 | url = }}</ref>
| update_citations = yes
 
}}
Nop7p-[[ERB1|Erb1p]]-Ytm1p, found in yeast, is potentially the [[Homology (biology)|homologous]] complex of Pes1-Bop1-WDR12 as it is involved in the control of ribosome biogenesis and [[S phase]] entry. The integrity of the PeBoW complex is required for ribosome biogenesis and cell proliferation in [[mammalia]]n [[Cell (biology)|cells]].<ref name="pmid16043514">{{cite journal | vauthors = Hölzel M, Rohrmoser M, Schlee M, Grimm T, Harasim T, Malamoussi A, Gruber-Eber A, Kremmer E, Hiddemann W, Bornkamm GW, Eick D | title = Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation | journal = J. Cell Biol. | volume = 170 | issue = 3 | pages = 367–78 | date = August 2005 | pmid = 16043514 | pmc = 2171466 | doi = 10.1083/jcb.200501141 | url = }}</ref> In Giardia, the [[species]] specific [[cytoskeleton]] protein, beta-giardin, [[Protein-protein interaction|interact]]s with Bop1.<ref name="pmid16362343"/>


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Structure ==
{{GNF_Protein_box
{{Infobox protein family
| image = 
| align = left
| image_source = 
| Symbol = BOP1NT
| PDB =
| Name = BOP1NT
| Name = Block of proliferation 1
| image =  
| HGNCid = 15519
| width =  
| Symbol = BOP1
| caption =  
| AltSymbols =; KIAA0124
| Pfam = PF08145
| OMIM = 610596
| Pfam_clan =   
| ECnumber = 
| InterPro = IPR012953
| Homologene = 6612
| SMART =  
| MGIid = 1334460
| PROSITE =  
| GeneAtlas_image1 = PBB_GE_BOP1_212563_at_tn.png
| MEROPS =  
| GeneAtlas_image2 = PBB_GE_BOP1_216397_s_at_tn.png
| SCOP =  
| Function =
| TCDB =  
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| OPM family =  
| Process = {{GNF_GO|id=GO:0006364 |text = rRNA processing}}
| OPM protein =  
| Orthologs = {{GNF_Ortholog_box
| CAZy =  
    | Hs_EntrezGene = 23246
| CDD =  
    | Hs_Ensembl = ENSG00000170727
    | Hs_RefseqProtein = NP_056016
    | Hs_RefseqmRNA = NM_015201
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 145456928
    | Hs_GenLoc_end = 145485928
    | Hs_Uniprot = Q14137
    | Mm_EntrezGene = 12181
    | Mm_Ensembl = ENSMUSG00000022557
    | Mm_RefseqmRNA = NM_013481
    | Mm_RefseqProtein = NP_038509
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 76280251
    | Mm_GenLoc_end = 76304524
    | Mm_Uniprot = Q3THV0
  }}
}}
}}
'''Block of proliferation 1''', also known as '''BOP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BOP1 block of proliferation 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23246| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
BOP1 contains a conserved [[N-terminal]] domain, BOP1NT.
{{PBB_Summary
{{Clear left}}
| section_title =
| summary_text =
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|BOP1}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal | vauthors = Zhang Y, Koushik S, Dai R, Mivechi NF | title = Structural organization and promoter analysis of murine heat shock transcription factor-1 gene. | journal = J. Biol. Chem. | volume = 273 | issue = 49 | pages = 32514–21 | year = 1999 | pmid = 9829985 | doi = 10.1074/jbc.273.49.32514 }}
| citations =
*{{cite journal | vauthors = Nakatsura T, Senju S, Yamada K, Jotsuka T, Ogawa M, Nishimura Y | title = Gene cloning of immunogenic antigens overexpressed in pancreatic cancer. | journal = Biochem. Biophys. Res. Commun. | volume = 281 | issue = 4 | pages = 936–44 | year = 2001 | pmid = 11237751 | doi = 10.1006/bbrc.2001.4377 }}
*{{cite journal | author=Nagase T, Seki N, Tanaka A, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 4 |pages= 167-74, 199-210 |year= 1996 |pmid= 8590280 |doi=  }}
*{{cite journal | vauthors = Pestov DG, Strezoska Z, Lau LF | title = Evidence of p53-dependent cross-talk between ribosome biogenesis and the cell cycle: effects of nucleolar protein Bop1 on G(1)/S transition. | journal = Mol. Cell. Biol. | volume = 21 | issue = 13 | pages = 4246–55 | year = 2001 | pmid = 11390653 | pmc = 87085 | doi = 10.1128/MCB.21.13.4246-4255.2001 }}
*{{cite journal  | author=Zhang Y, Koushik S, Dai R, Mivechi NF |title=Structural organization and promoter analysis of murine heat shock transcription factor-1 gene. |journal=J. Biol. Chem. |volume=273 |issue= 49 |pages= 32514-21 |year= 1999 |pmid= 9829985 |doi= }}
*{{cite journal | vauthors = Pestov DG, Stockelman MG, Strezoska Z, Lau LF | title = ERB1, the yeast homolog of mammalian Bop1, is an essential gene required for maturation of the 25S and 5.8S ribosomal RNAs. | journal = Nucleic Acids Res. | volume = 29 | issue = 17 | pages = 3621–30 | year = 2001 | pmid = 11522832 | pmc = 55883 | doi = 10.1093/nar/29.17.3621 }}
*{{cite journal | author=Nakatsura T, Senju S, Yamada K, ''et al.'' |title=Gene cloning of immunogenic antigens overexpressed in pancreatic cancer. |journal=Biochem. Biophys. Res. Commun. |volume=281 |issue= 4 |pages= 936-44 |year= 2001 |pmid= 11237751 |doi= 10.1006/bbrc.2001.4377 }}
*{{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus. | journal = Curr. Biol. | volume = 12 | issue = 1 | pages = 1–11 | year = 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 }}
*{{cite journal | author=Pestov DG, Strezoska Z, Lau LF |title=Evidence of p53-dependent cross-talk between ribosome biogenesis and the cell cycle: effects of nucleolar protein Bop1 on G(1)/S transition. |journal=Mol. Cell. Biol. |volume=21 |issue= 13 |pages= 4246-55 |year= 2001 |pmid= 11390653 |doi= 10.1128/MCB.21.13.4246-4255.2001 }}
*{{cite journal | vauthors = Strezoska Z, Pestov DG, Lau LF | title = Functional inactivation of the mouse nucleolar protein Bop1 inhibits multiple steps in pre-rRNA processing and blocks cell cycle progression. | journal = J. Biol. Chem. | volume = 277 | issue = 33 | pages = 29617–25 | year = 2002 | pmid = 12048210 | doi = 10.1074/jbc.M204381200 }}
*{{cite journal | author=Pestov DG, Stockelman MG, Strezoska Z, Lau LF |title=ERB1, the yeast homolog of mammalian Bop1, is an essential gene required for maturation of the 25S and 5.8S ribosomal RNAs. |journal=Nucleic Acids Res. |volume=29 |issue= 17 |pages= 3621-30 |year= 2001 |pmid= 11522832 |doi= }}
*{{cite journal | vauthors = Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ | title = Functional proteomic analysis of human nucleolus. | journal = Mol. Biol. Cell | volume = 13 | issue = 11 | pages = 4100–9 | year = 2003 | pmid = 12429849 | pmc = 133617 | doi = 10.1091/mbc.E02-05-0271 }}
*{{cite journal | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi= }}
*{{cite journal | vauthors = Lapik YR, Fernandes CJ, Lau LF, Pestov DG | title = Physical and functional interaction between Pes1 and Bop1 in mammalian ribosome biogenesis. | journal = Mol. Cell | volume = 15 | issue = 1 | pages = 17–29 | year = 2004 | pmid = 15225545 | doi = 10.1016/j.molcel.2004.05.020 }}
*{{cite journal | author=Strezoska Z, Pestov DG, Lau LF |title=Functional inactivation of the mouse nucleolar protein Bop1 inhibits multiple steps in pre-rRNA processing and blocks cell cycle progression. |journal=J. Biol. Chem. |volume=277 |issue= 33 |pages= 29617-25 |year= 2002 |pmid= 12048210 |doi= 10.1074/jbc.M204381200 }}
*{{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics. | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | year = 2005 | pmid = 15635413 | doi = 10.1038/nature03207 }}
*{{cite journal | author=Scherl A, Couté Y, Déon C, ''et al.'' |title=Functional proteomic analysis of human nucleolus. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4100-9 |year= 2003 |pmid= 12429849 |doi= 10.1091/mbc.E02-05-0271 }}
*{{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 14 | pages = 5391–6 | year = 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization. | journal = Nat. Biotechnol. | volume = 24 | issue = 10 | pages = 1285–92 | year = 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}
*{{cite journal  | author=Lapik YR, Fernandes CJ, Lau LF, Pestov DG |title=Physical and functional interaction between Pes1 and Bop1 in mammalian ribosome biogenesis. |journal=Mol. Cell |volume=15 |issue= 1 |pages= 17-29 |year= 2004 |pmid= 15225545 |doi= 10.1016/j.molcel.2004.05.020 }}
*{{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry. | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal  | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal | author=Nousiainen M, Silljé HH, Sauer G, ''et al.'' |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391-6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 }}
*{{cite journal | author=Killian A, Sarafan-Vasseur N, Sesboüé R, ''et al.'' |title=Contribution of the BOP1 gene, located on 8q24, to colorectal tumorigenesis. |journal=Genes Chromosomes Cancer |volume=45 |issue= 9 |pages= 874-81 |year= 2006 |pmid= 16804918 |doi= 10.1002/gcc.20351 }}
*{{cite journal  | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{InterPro content|IPR012953}}
{{WikiDoc Sources}}
 
[[Category:Protein domains]]
 
 
{{gene-8-stub}}

Latest revision as of 02:38, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ribosome biogenesis protein BOP1 is a protein that in humans is encoded by the BOP1 gene.[1][2]

Function

It is a WD40 repeat-containing nucleolar protein involved in rRNA processing, thereby controlling the cell cycle.[3] It is required for the maturation of the 25S and 5.8S ribosomal RNAs. It may serve as an essential factor in ribosome formation that coordinates processing of the spacer regions in pre-rRNA. The Pes1-Bop1 complex has several components: BOP1, GRWD1, PES1, ORC6L, and RPL3 and is involved in ribosome biogenesis and altered chromosome segregation. The overexpression of BOP1 increases the percentage of multipolar spindles in human cells. Deregulation of the BOP1 pathway may contribute to colorectal tumourigenesis in humans.[4] Elevated levels of Bop1 induces Bop1/WDR12 and Bop1/Pes1 subcomplexes and the assembly and integrity of the PeBoW complex is highly sensitive to changes in Bop1 protein levels.[5]

Nop7p-Erb1p-Ytm1p, found in yeast, is potentially the homologous complex of Pes1-Bop1-WDR12 as it is involved in the control of ribosome biogenesis and S phase entry. The integrity of the PeBoW complex is required for ribosome biogenesis and cell proliferation in mammalian cells.[6] In Giardia, the species specific cytoskeleton protein, beta-giardin, interacts with Bop1.[3]

Structure

BOP1NT
Identifiers
SymbolBOP1NT
PfamPF08145
InterProIPR012953

BOP1 contains a conserved N-terminal domain, BOP1NT.

References

  1. ↑ Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (Mar 1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
  2. ↑ "Entrez Gene: BOP1 block of proliferation 1".
  3. ↑ 3.0 3.1 Kim J, Goo SY, Chung HJ, Yang HW, Yong TS, Lee KH, Park SJ (January 2006). "Interaction of beta-giardin with the Bop1 protein in Giardia lamblia". Parasitol. Res. 98 (2): 138–44. doi:10.1007/s00436-005-0040-8. PMID 16362343.
  4. ↑ Killian A, Sarafan-Vasseur N, Sesboüé R, Le Pessot F, Blanchard F, Lamy A, Laurent M, Flaman JM, Frébourg T (September 2006). "Contribution of the BOP1 gene, located on 8q24, to colorectal tumorigenesis". Genes Chromosomes Cancer. 45 (9): 874–81. doi:10.1002/gcc.20351. PMID 16804918.
  5. ↑ Rohrmoser M, Hölzel M, Grimm T, Malamoussi A, Harasim T, Orban M, Pfisterer I, Gruber-Eber A, Kremmer E, Eick D (May 2007). "Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit". Mol. Cell. Biol. 27 (10): 3682–94. doi:10.1128/MCB.00172-07. PMC 1899993. PMID 17353269.
  6. ↑ Hölzel M, Rohrmoser M, Schlee M, Grimm T, Harasim T, Malamoussi A, Gruber-Eber A, Kremmer E, Hiddemann W, Bornkamm GW, Eick D (August 2005). "Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation". J. Cell Biol. 170 (3): 367–78. doi:10.1083/jcb.200501141. PMC 2171466. PMID 16043514.

External links

Further reading

This article incorporates text from the public domain Pfam and InterPro: IPR012953


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