TYRP1: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Tyrosinase-related protein 1''', also known as '''TYRP1''', is an [[enzyme]] which in humans is encoded by the ''TYRP1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TYRP1 tyrosinase-related protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7306| accessdate = }}</ref><ref name="pmid9434945">{{cite journal | vauthors = Box NF, Wyeth JR, Mayne CJ, O'Gorman LE, Martin NG, Sturm RA | title = Complete sequence and polymorphism study of the human TYRP1 gene encoding tyrosinase-related protein 1 | journal = Mamm. Genome | volume = 9 | issue = 1 | pages = 50–3  | date = January 1998 | pmid = 9434945 | doi = 10.1007/s003359900678 }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Tyrosinase-related protein 1
| HGNCid = 12450
| Symbol = TYRP1
| AltSymbols =; CAS2; CATB; GP75; TRP; TYRP; b-PROTEIN
| OMIM = 115501
| ECnumber = 
| Homologene = 464
| MGIid = 98881
| GeneAtlas_image1 = PBB_GE_TYRP1_205694_at_tn.png
| Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0005507 |text = copper ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042470 |text = melanosome}}
| Process = {{GNF_GO|id=GO:0006583 |text = melanin biosynthetic process from tyrosine}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0043473 |text = pigmentation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7306
    | Hs_Ensembl = ENSG00000107165
    | Hs_RefseqProtein = NP_000541
    | Hs_RefseqmRNA = NM_000550
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 12683435
    | Hs_GenLoc_end = 12700290
    | Hs_Uniprot = P17643
    | Mm_EntrezGene = 22178
    | Mm_Ensembl = ENSMUSG00000005994
    | Mm_RefseqmRNA = NM_031202
    | Mm_RefseqProtein = NP_112479
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 80305461
    | Mm_GenLoc_end = 80322950
    | Mm_Uniprot = Q3UFK6
  }}
}}
'''Tyrosinase-related protein 1''', also known as '''TYRP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TYRP1 tyrosinase-related protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7306| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
Tyrp1 is a [[melanocyte]]-specific gene product involved in [[melanin]] synthesis. While mouse Tyrp1 possesses dihydroxyindole carboxylic acid oxidase activity, the function in human melanocytes is less clear. In addition to its role in melanin synthesis, Tyrp1 is involved in stabilizing of [[tyrosinase]] protein and modulating its catalytic activity. Tyrp1 is also involved in maintenance of [[melanosome]] structure and affects melanocyte proliferation and melanocyte cell death.<ref name="pmid11775055">{{cite journal | vauthors = Sarangarajan R, Boissy RE | title = Tyrp1 and oculocutaneous albinism type 3 | journal = Pigment Cell Res. | volume = 14 | issue = 6 | pages = 437–44  | date = December 2001 | pmid = 11775055 | doi = 10.1034/j.1600-0749.2001.140603.x }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== Clinical significance ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Sarangarajan R, Boissy RE |title=Tyrp1 and oculocutaneous albinism type 3. |journal=Pigment Cell Res. |volume=14 |issue= 6 |pages= 437-44 |year= 2002 |pmid= 11775055 |doi=  }}
*{{cite journal  | author=Lowings P, Yavuzer U, Goding CR |title=Positive and negative elements regulate a melanocyte-specific promoter. |journal=Mol. Cell. Biol. |volume=12 |issue= 8 |pages= 3653-62 |year= 1992 |pmid= 1321344 |doi=  }}
*{{cite journal  | author=Shibata K, Takeda K, Tomita Y, ''et al.'' |title=Downstream region of the human tyrosinase-related protein gene enhances its promoter activity. |journal=Biochem. Biophys. Res. Commun. |volume=184 |issue= 2 |pages= 568-75 |year= 1992 |pmid= 1575733 |doi=  }}
*{{cite journal  | author=Murty VV, Bouchard B, Mathew S, ''et al.'' |title=Assignment of the human TYRP (brown) locus to chromosome region 9p23 by nonradioactive in situ hybridization. |journal=Genomics |volume=13 |issue= 1 |pages= 227-9 |year= 1992 |pmid= 1577487 |doi=  }}
*{{cite journal  | author=Colman MA, Shibahara S, Kwon B, ''et al.'' |title=A two allele XbaI RFLP at the catalase 2 locus. |journal=Nucleic Acids Res. |volume=19 |issue= 4 |pages= 960 |year= 1991 |pmid= 1673236 |doi=  }}
*{{cite journal  | author=Halaban R, Moellmann G |title=Murine and human b locus pigmentation genes encode a glycoprotein (gp75) with catalase activity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 12 |pages= 4809-13 |year= 1990 |pmid= 1693779 |doi=  }}
*{{cite journal  | author=Abbott C, Jackson IJ, Carritt B, Povey S |title=The human homolog of the mouse brown gene maps to the short arm of chromosome 9 and extends the known region of homology with mouse chromosome 4. |journal=Genomics |volume=11 |issue= 2 |pages= 471-3 |year= 1992 |pmid= 1769662 |doi=  }}
*{{cite journal  | author=Chintamaneni CD, Ramsay M, Colman MA, ''et al.'' |title=Mapping the human CAS2 gene, the homologue of the mouse brown (b) locus, to human chromosome 9p22-pter. |journal=Biochem. Biophys. Res. Commun. |volume=178 |issue= 1 |pages= 227-35 |year= 1991 |pmid= 1906272 |doi=  }}
*{{cite journal  | author=Urquhart A |title=Human tyrosinase-like protein (TYRL) carboxy terminus: closer homology with the mouse protein than previously reported. |journal=Nucleic Acids Res. |volume=19 |issue= 20 |pages= 5803 |year= 1991 |pmid= 1945866 |doi=  }}
*{{cite journal  | author=Cohen T, Muller RM, Tomita Y, Shibahara S |title=Nucleotide sequence of the cDNA encoding human tyrosinase-related protein. |journal=Nucleic Acids Res. |volume=18 |issue= 9 |pages= 2807-8 |year= 1990 |pmid= 2111010 |doi=  }}
*{{cite journal  | author=Vijayasaradhi S, Bouchard B, Houghton AN |title=The melanoma antigen gp75 is the human homologue of the mouse b (brown) locus gene product. |journal=J. Exp. Med. |volume=171 |issue= 4 |pages= 1375-80 |year= 1990 |pmid= 2324688 |doi=  }}
*{{cite journal  | author=Box NF, Sturm RA |title=Dinucleotide repeat polymorphism at the human TYRP1 locus. |journal=Hum. Mol. Genet. |volume=3 |issue= 12 |pages= 2270 |year= 1995 |pmid= 7881448 |doi=  }}
*{{cite journal  | author=Orlow SJ, Zhou BK, Chakraborty AK, ''et al.'' |title=High-molecular-weight forms of tyrosinase and the tyrosinase-related proteins: evidence for a melanogenic complex. |journal=J. Invest. Dermatol. |volume=103 |issue= 2 |pages= 196-201 |year= 1994 |pmid= 8040609 |doi=  }}
*{{cite journal  | author=Sturm RA, O'Sullivan BJ, Box NF, ''et al.'' |title=Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family. |journal=Genomics |volume=29 |issue= 1 |pages= 24-34 |year= 1996 |pmid= 8530077 |doi= 10.1006/geno.1995.1211 }}
*{{cite journal  | author=Boissy RE, Zhao H, Oetting WS, ''et al.'' |title=Mutation in and lack of expression of tyrosinase-related protein-1 (TRP-1) in melanocytes from an individual with brown oculocutaneous albinism: a new subtype of albinism classified as "OCA3". |journal=Am. J. Hum. Genet. |volume=58 |issue= 6 |pages= 1145-56 |year= 1996 |pmid= 8651291 |doi=  }}
*{{cite journal  | author=Manga P, Kromberg JG, Box NF, ''et al.'' |title=Rufous oculocutaneous albinism in southern African Blacks is caused by mutations in the TYRP1 gene. |journal=Am. J. Hum. Genet. |volume=61 |issue= 5 |pages= 1095-101 |year= 1997 |pmid= 9345097 |doi=  }}
*{{cite journal  | author=Box NF, Wyeth JR, Mayne CJ, ''et al.'' |title=Complete sequence and polymorphism study of the human TYRP1 gene encoding tyrosinase-related protein 1. |journal=Mamm. Genome |volume=9 |issue= 1 |pages= 50-3 |year= 1998 |pmid= 9434945 |doi=  }}
*{{cite journal  | author=Bertolotto C, Buscà R, Abbe P, ''et al.'' |title=Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia. |journal=Mol. Cell. Biol. |volume=18 |issue= 2 |pages= 694-702 |year= 1998 |pmid= 9447965 |doi=  }}
*{{cite journal  | author=Abe T, Sato M, Tamai M |title=Dedifferentiation of the retinal pigment epithelium compared to the proliferative membranes of proliferative vitreoretinopathy. |journal=Curr. Eye Res. |volume=17 |issue= 12 |pages= 1103-9 |year= 1999 |pmid= 9872531 |doi=  }}
*{{cite journal  | author=Commo S, Bernard BA |title=Melanocyte subpopulation turnover during the human hair cycle: an immunohistochemical study. |journal=Pigment Cell Res. |volume=13 |issue= 4 |pages= 253-9 |year= 2000 |pmid= 10952393 |doi=  }}
}}
{{refend}}


{{protein-stub}}
Mutations in the mouse Tyrp1 gene are associated with brown [[pelage]] and in the human TYRP1 gene with [[oculocutaneous albinism]] type 3 (OCA3).<ref name="pmid11775055"/> An allele of TYRP1 common in [[Solomon Islands|Solomon Islanders]] results in blond hair. Although the phenotype is similar to Northern European blond hair, this allele is not found in Europeans.<ref>{{cite news |title=Another Genetic Quirk of the Solomon Islands: Blond Hair |author=Sindya N. Bhanoo |url=https://www.nytimes.com/2012/05/08/science/another-genetic-quirk-of-the-solomon-islands-blond-hair.html |newspaper=The New York Times |date=3 May 2012 |accessdate=3 May 2012}}</ref><ref name="doi.10.1126/science.1217849">{{cite journal | vauthors = Kenny EE, Timpson NJ, Sikora M, Yee MC, Moreno-Estrada A, Eng C, Huntsman S, Burchard EG, Stoneking M, Bustamante CD, Myles S | title = Melanesian blond hair is caused by an amino acid change in TYRP1 | journal = Science | volume = 336 | issue = 6081 | pages = 554  | date = 3 May 2012 | pmid = 22556244 | pmc = 3481182 | doi = 10.1126/science.1217849 }}</ref>
{{WikiDoc Sources}}
 
== Regulation ==
 
The expression of TYRP1 is regulated by the [[microphthalmia-associated transcription factor]] (MITF).<ref name="pmid12136092">{{cite journal | vauthors = Fang D, Tsuji Y, Setaluri V | title = Selective down-regulation of tyrosinase family gene TYRP1 by inhibition of the activity of melanocyte transcription factor, MITF | journal = Nucleic Acids Res. | volume = 30 | issue = 14 | pages = 3096–106 | year = 2002 | pmid = 12136092 | pmc = 135745 | doi = 10.1093/nar/gkf424 }}</ref><ref name="pmidunknown">{{cite journal | vauthors = Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell Melanoma Res | volume = 21 | issue = 6 | pages = 665–76 | year = 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x }}</ref>
 
== Interactions ==
 
TYRP1 has been shown to [[Protein-protein interaction|interact]] with [[GIPC1]].<ref name=pmid11441007>{{cite journal | vauthors = Liu TF, Kandala G, Setaluri V | title = PDZ domain protein GIPC interacts with the cytoplasmic tail of melanosomal membrane protein gp75 (tyrosinase-related protein-1) | journal = J. Biol. Chem. | volume = 276 | issue = 38 | pages = 35768–77  | date = September 2001 | pmid = 11441007 | doi = 10.1074/jbc.M103585200 }}</ref>
 
== See also ==
* [[Dopachrome tautomerase]] (DCT; also known as TYRP2)
 
== References ==
{{Reflist}}
 
== Further reading ==
{{Refbegin|2}}
* {{cite journal | vauthors = Sarangarajan R, Boissy RE | title = Tyrp1 and oculocutaneous albinism type 3 | journal = Pigment Cell Res. | volume = 14 | issue = 6 | pages = 437–44 | year = 2001 | pmid = 11775055 | doi = 10.1034/j.1600-0749.2001.140603.x }}
* {{cite journal | vauthors = Lowings P, Yavuzer U, Goding CR | title = Positive and negative elements regulate a melanocyte-specific promoter | journal = Mol. Cell. Biol. | volume = 12 | issue = 8 | pages = 3653–62 | year = 1992 | pmid = 1321344 | pmc = 364632 | doi =  }}
* {{cite journal | vauthors = Shibata K, Takeda K, Tomita Y, Tagami H, Shibahara S | title = Downstream region of the human tyrosinase-related protein gene enhances its promoter activity | journal = Biochem. Biophys. Res. Commun. | volume = 184 | issue = 2 | pages = 568–75 | year = 1992 | pmid = 1575733 | doi = 10.1016/0006-291X(92)90627-W }}
* {{cite journal | vauthors = Murty VV, Bouchard B, Mathew S, Vijayasaradhi S, Houghton AN | title = Assignment of the human TYRP (brown) locus to chromosome region 9p23 by nonradioactive in situ hybridization | journal = Genomics | volume = 13 | issue = 1 | pages = 227–9 | year = 1992 | pmid = 1577487 | doi = 10.1016/0888-7543(92)90228-K }}
* {{cite journal | vauthors = Colman MA, Shibahara S, Kwon B, Jenkins T, Ramsay M | title = A two allele XbaI RFLP at the catalase 2 locus | journal = Nucleic Acids Res. | volume = 19 | issue = 4 | pages = 960 | year = 1991 | pmid = 1673236 | pmc = 333744 | doi = 10.1093/nar/19.4.960-a }}
* {{cite journal | vauthors = Halaban R, Moellmann G | title = Murine and human b locus pigmentation genes encode a glycoprotein (gp75) with catalase activity | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 87 | issue = 12 | pages = 4809–13 | year = 1990 | pmid = 1693779 | pmc = 54207 | doi = 10.1073/pnas.87.12.4809 }}
* {{cite journal | vauthors = Abbott C, Jackson IJ, Carritt B, Povey S | title = The human homolog of the mouse brown gene maps to the short arm of chromosome 9 and extends the known region of homology with mouse chromosome 4 | journal = Genomics | volume = 11 | issue = 2 | pages = 471–3 | year = 1991 | pmid = 1769662 | doi = 10.1016/0888-7543(91)90160-G }}
* {{cite journal | vauthors = Chintamaneni CD, Ramsay M, Colman MA, Fox MF, Pickard RT, Kwon BS | title = Mapping the human CAS2 gene, the homologue of the mouse brown (b) locus, to human chromosome 9p22-pter | journal = Biochem. Biophys. Res. Commun. | volume = 178 | issue = 1 | pages = 227–35 | year = 1991 | pmid = 1906272 | doi = 10.1016/0006-291X(91)91803-K }}
* {{cite journal | vauthors = Urquhart A | title = Human tyrosinase-like protein (TYRL) carboxy terminus: closer homology with the mouse protein than previously reported | journal = Nucleic Acids Res. | volume = 19 | issue = 20 | pages = 5803 | year = 1991 | pmid = 1945866 | pmc = 329017 | doi = 10.1093/nar/19.20.5803 }}
* {{cite journal | vauthors = Cohen T, Muller RM, Tomita Y, Shibahara S | title = Nucleotide sequence of the cDNA encoding human tyrosinase-related protein | journal = Nucleic Acids Res. | volume = 18 | issue = 9 | pages = 2807–8 | year = 1990 | pmid = 2111010 | pmc = 330768 | doi = 10.1093/nar/18.9.2807 }}
* {{cite journal | vauthors = Vijayasaradhi S, Bouchard B, Houghton AN | title = The melanoma antigen gp75 is the human homologue of the mouse b (brown) locus gene product | journal = J. Exp. Med. | volume = 171 | issue = 4 | pages = 1375–80 | year = 1990 | pmid = 2324688 | pmc = 2187848 | doi = 10.1084/jem.171.4.1375 }}
* {{cite journal | vauthors = Box NF, Sturm RA | title = Dinucleotide repeat polymorphism at the human TYRP1 locus | journal = Hum. Mol. Genet. | volume = 3 | issue = 12 | pages = 2270 | year = 1994 | pmid = 7881448 | doi = 10.1093/hmg/3.12.2270 }}
* {{cite journal | vauthors = Orlow SJ, Zhou BK, Chakraborty AK, Drucker M, Pifko-Hirst S, Pawelek JM | title = High-molecular-weight forms of tyrosinase and the tyrosinase-related proteins: evidence for a melanogenic complex | journal = J. Invest. Dermatol. | volume = 103 | issue = 2 | pages = 196–201 | year = 1994 | pmid = 8040609 | doi = 10.1111/1523-1747.ep12392743 }}
* {{cite journal | vauthors = Sturm RA, O'Sullivan BJ, Box NF, Smith AG, Smit SE, Puttick ER, Parsons PG, Dunn IS | title = Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family | journal = Genomics | volume = 29 | issue = 1 | pages = 24–34 | year = 1995 | pmid = 8530077 | doi = 10.1006/geno.1995.1211 }}
* {{cite journal | vauthors = Boissy RE, Zhao H, Oetting WS, Austin LM, Wildenberg SC, Boissy YL, Zhao Y, Sturm RA, Hearing VJ, King RA, Nordlund JJ | title = Mutation in and lack of expression of tyrosinase-related protein-1 (TRP-1) in melanocytes from an individual with brown oculocutaneous albinism: a new subtype of albinism classified as "OCA3" | journal = Am. J. Hum. Genet. | volume = 58 | issue = 6 | pages = 1145–56 | year = 1996 | pmid = 8651291 | pmc = 1915069 | doi =  }}
* {{cite journal | vauthors = Manga P, Kromberg JG, Box NF, Sturm RA, Jenkins T, Ramsay M | title = Rufous oculocutaneous albinism in southern African Blacks is caused by mutations in the TYRP1 gene | journal = Am. J. Hum. Genet. | volume = 61 | issue = 5 | pages = 1095–101 | year = 1997 | pmid = 9345097 | pmc = 1716031 | doi = 10.1086/301603 }}
* {{cite journal | vauthors = Box NF, Wyeth JR, Mayne CJ, O'Gorman LE, Martin NG, Sturm RA | title = Complete sequence and polymorphism study of the human TYRP1 gene encoding tyrosinase-related protein 1 | journal = Mamm. Genome | volume = 9 | issue = 1 | pages = 50–3 | year = 1998 | pmid = 9434945 | doi = 10.1007/s003359900678 }}
* {{cite journal | vauthors = Bertolotto C, Buscà R, Abbe P, Bille K, Aberdam E, Ortonne JP, Ballotti R | title = Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia | journal = Mol. Cell. Biol. | volume = 18 | issue = 2 | pages = 694–702 | year = 1998 | pmid = 9447965 | pmc = 108780 | doi =  10.1128/mcb.18.2.694}}
* {{cite journal | vauthors = Abe T, Sato M, Tamai M | title = Dedifferentiation of the retinal pigment epithelium compared to the proliferative membranes of proliferative vitreoretinopathy | journal = Curr. Eye Res. | volume = 17 | issue = 12 | pages = 1103–9 | year = 1998 | pmid = 9872531 | doi = 10.1076/ceyr.17.12.1103.5126 }}
* {{cite journal | vauthors = Commo S, Bernard BA | title = Melanocyte subpopulation turnover during the human hair cycle: an immunohistochemical study | journal = Pigment Cell Res. | volume = 13 | issue = 4 | pages = 253–9 | year = 2000 | pmid = 10952393 | doi = 10.1034/j.1600-0749.2000.130407.x }}
{{Refend}}

Latest revision as of 12:32, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Tyrosinase-related protein 1, also known as TYRP1, is an enzyme which in humans is encoded by the TYRP1 gene.[1][2]

Function

Tyrp1 is a melanocyte-specific gene product involved in melanin synthesis. While mouse Tyrp1 possesses dihydroxyindole carboxylic acid oxidase activity, the function in human melanocytes is less clear. In addition to its role in melanin synthesis, Tyrp1 is involved in stabilizing of tyrosinase protein and modulating its catalytic activity. Tyrp1 is also involved in maintenance of melanosome structure and affects melanocyte proliferation and melanocyte cell death.[3]

Clinical significance

Mutations in the mouse Tyrp1 gene are associated with brown pelage and in the human TYRP1 gene with oculocutaneous albinism type 3 (OCA3).[3] An allele of TYRP1 common in Solomon Islanders results in blond hair. Although the phenotype is similar to Northern European blond hair, this allele is not found in Europeans.[4][5]

Regulation

The expression of TYRP1 is regulated by the microphthalmia-associated transcription factor (MITF).[6][7]

Interactions

TYRP1 has been shown to interact with GIPC1.[8]

See also

References

  1. ↑ "Entrez Gene: TYRP1 tyrosinase-related protein 1".
  2. ↑ Box NF, Wyeth JR, Mayne CJ, O'Gorman LE, Martin NG, Sturm RA (January 1998). "Complete sequence and polymorphism study of the human TYRP1 gene encoding tyrosinase-related protein 1". Mamm. Genome. 9 (1): 50–3. doi:10.1007/s003359900678. PMID 9434945.
  3. ↑ 3.0 3.1 Sarangarajan R, Boissy RE (December 2001). "Tyrp1 and oculocutaneous albinism type 3". Pigment Cell Res. 14 (6): 437–44. doi:10.1034/j.1600-0749.2001.140603.x. PMID 11775055.
  4. ↑ Sindya N. Bhanoo (3 May 2012). "Another Genetic Quirk of the Solomon Islands: Blond Hair". The New York Times. Retrieved 3 May 2012.
  5. ↑ Kenny EE, Timpson NJ, Sikora M, Yee MC, Moreno-Estrada A, Eng C, Huntsman S, Burchard EG, Stoneking M, Bustamante CD, Myles S (3 May 2012). "Melanesian blond hair is caused by an amino acid change in TYRP1". Science. 336 (6081): 554. doi:10.1126/science.1217849. PMC 3481182. PMID 22556244.
  6. ↑ Fang D, Tsuji Y, Setaluri V (2002). "Selective down-regulation of tyrosinase family gene TYRP1 by inhibition of the activity of melanocyte transcription factor, MITF". Nucleic Acids Res. 30 (14): 3096–106. doi:10.1093/nar/gkf424. PMC 135745. PMID 12136092.
  7. ↑ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
  8. ↑ Liu TF, Kandala G, Setaluri V (September 2001). "PDZ domain protein GIPC interacts with the cytoplasmic tail of melanosomal membrane protein gp75 (tyrosinase-related protein-1)". J. Biol. Chem. 276 (38): 35768–77. doi:10.1074/jbc.M103585200. PMID 11441007.

Further reading

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