Protein SET: Difference between revisions
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{{ | '''Protein SET''' is a [[protein]] that in humans is encoded by the ''SET'' [[gene]].<ref name="pmid1630450">{{cite journal | vauthors = von Lindern M, van Baal S, Wiegant J, Raap A, Hagemeijer A, Grosveld G | title = Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene | journal = Molecular and Cellular Biology | volume = 12 | issue = 8 | pages = 3346–55 | date = Aug 1992 | pmid = 1630450 | pmc = 364582 | doi = 10.1128/mcb.12.8.3346}}</ref><ref name="pmid8626647">{{cite journal | vauthors = Li M, Makkinje A, Damuni Z | title = The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A | journal = The Journal of Biological Chemistry | volume = 271 | issue = 19 | pages = 11059–62 | date = May 1996 | pmid = 8626647 | pmc = | doi = 10.1074/jbc.271.19.11059 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SET SET translocation (myeloid leukemia-associated)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6418| accessdate = }}</ref> | ||
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== Interactions == | |||
< | Protein SET has been shown to [[Protein-protein interaction|interact]] with: | ||
{{ | {{div col|colwidth=20em}} | ||
| | * [[Acidic leucine-rich nuclear phosphoprotein 32 family member A]],<ref name = pmid11163245/><ref name = pmid11909973>{{cite journal | vauthors = Fan Z, Beresford PJ, Zhang D, Lieberman J | title = HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A | journal = Molecular and Cellular Biology | volume = 22 | issue = 8 | pages = 2810–20 | date = Apr 2002 | pmid = 11909973 | pmc = 133744 | doi = 10.1128/mcb.22.8.2810-2820.2002}}</ref> | ||
| | * [[CDK5R1]],<ref name = pmid11741927>{{cite journal | vauthors = Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ | title = The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity | journal = The Journal of Biological Chemistry | volume = 277 | issue = 9 | pages = 7324–32 | date = Mar 2002 | pmid = 11741927 | doi = 10.1074/jbc.M107270200 }}</ref> | ||
}} | * [[KLF5]],<ref name = pmid14612398>{{cite journal | vauthors = Miyamoto S, Suzuki T, Muto S, Aizawa K, Kimura A, Mizuno Y, Nagino T, Imai Y, Adachi N, Horikoshi M, Nagai R | title = Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain | journal = Molecular and Cellular Biology | volume = 23 | issue = 23 | pages = 8528–41 | date = Dec 2003 | pmid = 14612398 | pmc = 262669 | doi = 10.1128/mcb.23.23.8528-8541.2003}}</ref> | ||
* [[NME1]],<ref name = pmid12628186>{{cite journal | vauthors = Fan Z, Beresford PJ, Oh DY, Zhang D, Lieberman J | title = Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor | journal = Cell | volume = 112 | issue = 5 | pages = 659–72 | date = Mar 2003 | pmid = 12628186 | doi = 10.1016/s0092-8674(03)00150-8}}</ref> and | |||
* [[TAF1A]].<ref name = pmid11163245>{{cite journal | vauthors = Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D | title = Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein | journal = Cell | volume = 104 | issue = 1 | pages = 119–30 | date = Jan 2001 | pmid = 11163245 | doi = 10.1016/s0092-8674(01)00196-9}}</ref> | |||
{{Div col end}} | |||
==References== | == References == | ||
{{ | {{Reflist}} | ||
==Further reading== | |||
== Further reading == | |||
{{refbegin | 2}} | {{refbegin | 2}} | ||
* {{cite journal | vauthors = Nagata K, Kawase H, Handa H, Yano K, Yamasaki M, Ishimi Y, Okuda A, Kikuchi A, Matsumoto K | title = Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 92 | issue = 10 | pages = 4279–83 | date = May 1995 | pmid = 7753797 | pmc = 41927 | doi = 10.1073/pnas.92.10.4279 }} | |||
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }} | |||
*{{cite journal | * {{cite journal | vauthors = Adachi Y, Pavlakis GN, Copeland TD | title = Identification of in vivo phosphorylation sites of SET, a nuclear phosphoprotein encoded by the translocation breakpoint in acute undifferentiated leukemia | journal = FEBS Letters | volume = 340 | issue = 3 | pages = 231–5 | date = Mar 1994 | pmid = 8131851 | doi = 10.1016/0014-5793(94)80144-4 }} | ||
* {{cite journal | vauthors = Vaesen M, Barnikol-Watanabe S, Götz H, Awni LA, Cole T, Zimmermann B, Kratzin HD, Hilschmann N | title = Purification and characterization of two putative HLA class II associated proteins: PHAPI and PHAPII | journal = Biological Chemistry Hoppe-Seyler | volume = 375 | issue = 2 | pages = 113–26 | date = Feb 1994 | pmid = 8192856 | doi = 10.1515/bchm3.1994.375.2.113 }} | |||
*{{cite journal | * {{cite journal | vauthors = Adachi Y, Pavlakis GN, Copeland TD | title = Identification and characterization of SET, a nuclear phosphoprotein encoded by the translocation break point in acute undifferentiated leukemia | journal = The Journal of Biological Chemistry | volume = 269 | issue = 3 | pages = 2258–62 | date = Jan 1994 | pmid = 8294483 | doi = }} | ||
*{{cite journal | * {{cite journal | vauthors = Adler HT, Nallaseth FS, Walter G, Tkachuk DC | title = HRX leukemic fusion proteins form a heterocomplex with the leukemia-associated protein SET and protein phosphatase 2A | journal = The Journal of Biological Chemistry | volume = 272 | issue = 45 | pages = 28407–14 | date = Nov 1997 | pmid = 9353299 | doi = 10.1074/jbc.272.45.28407 }} | ||
*{{cite journal | * {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }} | ||
*{{cite journal | * {{cite journal | vauthors = Carlson SG, Eng E, Kim EG, Perlman EJ, Copeland TD, Ballermann BJ | title = Expression of SET, an inhibitor of protein phosphatase 2A, in renal development and Wilms' tumor | journal = Journal of the American Society of Nephrology | volume = 9 | issue = 10 | pages = 1873–80 | date = Oct 1998 | pmid = 9773788 | doi = }} | ||
*{{cite journal | * {{cite journal | vauthors = Brennan CM, Gallouzi IE, Steitz JA | title = Protein ligands to HuR modulate its interaction with target mRNAs in vivo | journal = The Journal of Cell Biology | volume = 151 | issue = 1 | pages = 1–14 | date = Oct 2000 | pmid = 11018049 | pmc = 2189805 | doi = 10.1083/jcb.151.1.1 }} | ||
* {{cite journal | vauthors = Shikama N, Chan HM, Krstic-Demonacos M, Smith L, Lee CW, Cairns W, La Thangue NB | title = Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators | journal = Molecular and Cellular Biology | volume = 20 | issue = 23 | pages = 8933–43 | date = Dec 2000 | pmid = 11073993 | pmc = 86548 | doi = 10.1128/MCB.20.23.8933-8943.2000 }} | |||
*{{cite journal | * {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }} | ||
*{{cite journal | * {{cite journal | vauthors = Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D | title = Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein | journal = Cell | volume = 104 | issue = 1 | pages = 119–30 | date = Jan 2001 | pmid = 11163245 | doi = 10.1016/S0092-8674(01)00196-9 }} | ||
*{{cite journal | * {{cite journal | vauthors = Minakuchi M, Kakazu N, Gorrin-Rivas MJ, Abe T, Copeland TD, Ueda K, Adachi Y | title = Identification and characterization of SEB, a novel protein that binds to the acute undifferentiated leukemia-associated protein SET | journal = European Journal of Biochemistry / FEBS | volume = 268 | issue = 5 | pages = 1340–51 | date = Mar 2001 | pmid = 11231286 | doi = 10.1046/j.1432-1327.2001.02000.x }} | ||
*{{cite journal | * {{cite journal | vauthors = Beresford PJ, Zhang D, Oh DY, Fan Z, Greer EL, Russo ML, Jaju M, Lieberman J | title = Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks | journal = The Journal of Biological Chemistry | volume = 276 | issue = 46 | pages = 43285–93 | date = Nov 2001 | pmid = 11555662 | doi = 10.1074/jbc.M108137200 }} | ||
*{{cite journal | * {{cite journal | vauthors = Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ | title = The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity | journal = The Journal of Biological Chemistry | volume = 277 | issue = 9 | pages = 7324–32 | date = Mar 2002 | pmid = 11741927 | doi = 10.1074/jbc.M107270200 }} | ||
*{{cite journal | * {{cite journal | vauthors = Fan Z, Beresford PJ, Zhang D, Lieberman J | title = HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A | journal = Molecular and Cellular Biology | volume = 22 | issue = 8 | pages = 2810–20 | date = Apr 2002 | pmid = 11909973 | pmc = 133744 | doi = 10.1128/MCB.22.8.2810-2820.2002 }} | ||
*{{cite journal | * {{cite journal | vauthors = Cervoni N, Detich N, Seo SB, Chakravarti D, Szyf M | title = The oncoprotein Set/TAF-1beta, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing | journal = The Journal of Biological Chemistry | volume = 277 | issue = 28 | pages = 25026–31 | date = Jul 2002 | pmid = 11978794 | doi = 10.1074/jbc.M202256200 }} | ||
*{{cite journal | |||
*{{cite journal | |||
*{{cite journal | |||
*{{cite journal | |||
}} | |||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=6418}} | |||
[[Category:Histone Acetyltransferase Inhibitor]] | |||
{{protein-stub}} | {{protein-stub}} |
Latest revision as of 15:29, 8 September 2017
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
Wikidata | |||||||
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Protein SET is a protein that in humans is encoded by the SET gene.[1][2][3]
Interactions
Protein SET has been shown to interact with:
References
- ↑ von Lindern M, van Baal S, Wiegant J, Raap A, Hagemeijer A, Grosveld G (Aug 1992). "Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene". Molecular and Cellular Biology. 12 (8): 3346–55. doi:10.1128/mcb.12.8.3346. PMC 364582. PMID 1630450.
- ↑ Li M, Makkinje A, Damuni Z (May 1996). "The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A". The Journal of Biological Chemistry. 271 (19): 11059–62. doi:10.1074/jbc.271.19.11059. PMID 8626647.
- ↑ "Entrez Gene: SET SET translocation (myeloid leukemia-associated)".
- ↑ 4.0 4.1 Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (Jan 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell. 104 (1): 119–30. doi:10.1016/s0092-8674(01)00196-9. PMID 11163245.
- ↑ Fan Z, Beresford PJ, Zhang D, Lieberman J (Apr 2002). "HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A". Molecular and Cellular Biology. 22 (8): 2810–20. doi:10.1128/mcb.22.8.2810-2820.2002. PMC 133744. PMID 11909973.
- ↑ Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ (Mar 2002). "The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity". The Journal of Biological Chemistry. 277 (9): 7324–32. doi:10.1074/jbc.M107270200. PMID 11741927.
- ↑ Miyamoto S, Suzuki T, Muto S, Aizawa K, Kimura A, Mizuno Y, Nagino T, Imai Y, Adachi N, Horikoshi M, Nagai R (Dec 2003). "Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain". Molecular and Cellular Biology. 23 (23): 8528–41. doi:10.1128/mcb.23.23.8528-8541.2003. PMC 262669. PMID 14612398.
- ↑ Fan Z, Beresford PJ, Oh DY, Zhang D, Lieberman J (Mar 2003). "Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor". Cell. 112 (5): 659–72. doi:10.1016/s0092-8674(03)00150-8. PMID 12628186.
Further reading
- Nagata K, Kawase H, Handa H, Yano K, Yamasaki M, Ishimi Y, Okuda A, Kikuchi A, Matsumoto K (May 1995). "Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis". Proceedings of the National Academy of Sciences of the United States of America. 92 (10): 4279–83. doi:10.1073/pnas.92.10.4279. PMC 41927. PMID 7753797.
- Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Adachi Y, Pavlakis GN, Copeland TD (Mar 1994). "Identification of in vivo phosphorylation sites of SET, a nuclear phosphoprotein encoded by the translocation breakpoint in acute undifferentiated leukemia". FEBS Letters. 340 (3): 231–5. doi:10.1016/0014-5793(94)80144-4. PMID 8131851.
- Vaesen M, Barnikol-Watanabe S, Götz H, Awni LA, Cole T, Zimmermann B, Kratzin HD, Hilschmann N (Feb 1994). "Purification and characterization of two putative HLA class II associated proteins: PHAPI and PHAPII". Biological Chemistry Hoppe-Seyler. 375 (2): 113–26. doi:10.1515/bchm3.1994.375.2.113. PMID 8192856.
- Adachi Y, Pavlakis GN, Copeland TD (Jan 1994). "Identification and characterization of SET, a nuclear phosphoprotein encoded by the translocation break point in acute undifferentiated leukemia". The Journal of Biological Chemistry. 269 (3): 2258–62. PMID 8294483.
- Adler HT, Nallaseth FS, Walter G, Tkachuk DC (Nov 1997). "HRX leukemic fusion proteins form a heterocomplex with the leukemia-associated protein SET and protein phosphatase 2A". The Journal of Biological Chemistry. 272 (45): 28407–14. doi:10.1074/jbc.272.45.28407. PMID 9353299.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Carlson SG, Eng E, Kim EG, Perlman EJ, Copeland TD, Ballermann BJ (Oct 1998). "Expression of SET, an inhibitor of protein phosphatase 2A, in renal development and Wilms' tumor". Journal of the American Society of Nephrology. 9 (10): 1873–80. PMID 9773788.
- Brennan CM, Gallouzi IE, Steitz JA (Oct 2000). "Protein ligands to HuR modulate its interaction with target mRNAs in vivo". The Journal of Cell Biology. 151 (1): 1–14. doi:10.1083/jcb.151.1.1. PMC 2189805. PMID 11018049.
- Shikama N, Chan HM, Krstic-Demonacos M, Smith L, Lee CW, Cairns W, La Thangue NB (Dec 2000). "Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators". Molecular and Cellular Biology. 20 (23): 8933–43. doi:10.1128/MCB.20.23.8933-8943.2000. PMC 86548. PMID 11073993.
- Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (Jan 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell. 104 (1): 119–30. doi:10.1016/S0092-8674(01)00196-9. PMID 11163245.
- Minakuchi M, Kakazu N, Gorrin-Rivas MJ, Abe T, Copeland TD, Ueda K, Adachi Y (Mar 2001). "Identification and characterization of SEB, a novel protein that binds to the acute undifferentiated leukemia-associated protein SET". European Journal of Biochemistry / FEBS. 268 (5): 1340–51. doi:10.1046/j.1432-1327.2001.02000.x. PMID 11231286.
- Beresford PJ, Zhang D, Oh DY, Fan Z, Greer EL, Russo ML, Jaju M, Lieberman J (Nov 2001). "Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks". The Journal of Biological Chemistry. 276 (46): 43285–93. doi:10.1074/jbc.M108137200. PMID 11555662.
- Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ (Mar 2002). "The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity". The Journal of Biological Chemistry. 277 (9): 7324–32. doi:10.1074/jbc.M107270200. PMID 11741927.
- Fan Z, Beresford PJ, Zhang D, Lieberman J (Apr 2002). "HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A". Molecular and Cellular Biology. 22 (8): 2810–20. doi:10.1128/MCB.22.8.2810-2820.2002. PMC 133744. PMID 11909973.
- Cervoni N, Detich N, Seo SB, Chakravarti D, Szyf M (Jul 2002). "The oncoprotein Set/TAF-1beta, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing". The Journal of Biological Chemistry. 277 (28): 25026–31. doi:10.1074/jbc.M202256200. PMID 11978794.
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