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{{Infobox_gene}}
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'''Protein transport protein Sec61 subunit beta''' is a [[protein]] that in humans is encoded by the ''SEC61B'' [[gene]].<ref name="pmid8107851">{{cite journal | vauthors = Hartmann E, Sommer T, Prehn S, Gorlich D, Jentsch S, Rapoport TA | title = Evolutionary conservation of components of the protein translocation complex | journal = Nature | volume = 367 | issue = 6464 | pages = 654–7 |date=Mar 1994 | pmid = 8107851 | pmc =  | doi = 10.1038/367654a0 }}</ref><ref name="pmid10212142">{{cite journal | vauthors = Greenfield JJ, High S | title = The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment | journal = J Cell Sci | volume = 112 | issue =  10| pages = 1477–86 |date=Aug 1999 | pmid = 10212142 | pmc = | doi =  }}</ref><ref name="entrez"/>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Sec61 beta subunit
| HGNCid = 16993
| Symbol = SEC61B
| AltSymbols =;
| OMIM = 609214
| ECnumber = 
| Homologene = 38229
| MGIid = 1913462
| GeneAtlas_image1 = PBB_GE_SEC61B_203133_at_tn.png
| Function = {{GNF_GO|id=GO:0015450 |text = protein transmembrane transporter activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
  | Process = {{GNF_GO|id=GO:0006605 |text = protein targeting}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10952
    | Hs_Ensembl = ENSG00000106803
    | Hs_RefseqProtein = NP_006799
    | Hs_RefseqmRNA = NM_006808
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 101024380
    | Hs_GenLoc_end = 101032715
    | Hs_Uniprot = P60468
    | Mm_EntrezGene = 66212
    | Mm_Ensembl = ENSMUSG00000053317
    | Mm_RefseqmRNA = NM_024171
    | Mm_RefseqProtein = NP_077133
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 47495761
    | Mm_GenLoc_end = 47504333
    | Mm_Uniprot = Q9CQS8
  }}
}}
'''Sec61 beta subunit''', also known as '''SEC61B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SEC61B Sec61 beta subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10952| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.<ref name="entrez">{{cite web | title = Entrez Gene: SEC61B Sec61 beta subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10952| accessdate = }}</ref>
| summary_text = The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.<ref name="entrez">{{cite web | title = Entrez Gene: SEC61B Sec61 beta subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10952| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Hartmann E, Sommer T, Prehn S, ''et al.'' |title=Evolutionary conservation of components of the protein translocation complex. |journal=Nature |volume=367 |issue= 6464 |pages= 654-7 |year= 1994 |pmid= 8107851 |doi= 10.1038/367654a0 }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal   |vauthors=Wiertz EJ, Tortorella D, Bogyo M, etal |title=Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction |journal=Nature |volume=384 |issue= 6608 |pages= 432–8 |year= 1997 |pmid= 8945469 |doi= 10.1038/384432a0 }}
*{{cite journal | author=Wiertz EJ, Tortorella D, Bogyo M, ''et al.'' |title=Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction. |journal=Nature |volume=384 |issue= 6608 |pages= 432-8 |year= 1997 |pmid= 8945469 |doi= 10.1038/384432a0 }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | vauthors=Knight BC, High S |title=Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation complex |journal=Biochem. J. |volume=331 |issue=  Pt 1|pages= 161–7 |year= 1998 |pmid= 9512475 |doi= | pmc=1219334 }}
*{{cite journal  | author=Knight BC, High S |title=Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation complex. |journal=Biochem. J. |volume=331 ( Pt 1) |issue=  |pages= 161-7 |year= 1998 |pmid= 9512475 |doi=  }}
*{{cite journal  | vauthors=Chen Y, Le Cahérec F, Chuck SL |title=Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex |journal=J. Biol. Chem. |volume=273 |issue= 19 |pages= 11887–94 |year= 1998 |pmid= 9565615 |doi=10.1074/jbc.273.19.11887 }}
*{{cite journal  | author=Chen Y, Le Cahérec F, Chuck SL |title=Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex. |journal=J. Biol. Chem. |volume=273 |issue= 19 |pages= 11887-94 |year= 1998 |pmid= 9565615 |doi=  }}
*{{cite journal  | vauthors=Kalies KU, Rapoport TA, Hartmann E |title=The β Subunit of the Sec61 Complex Facilitates Cotranslational Protein Transport and Interacts with the Signal Peptidase during Translocation |journal=J. Cell Biol. |volume=141 |issue= 4 |pages= 887–94 |year= 1998 |pmid= 9585408 |doi=10.1083/jcb.141.4.887  | pmc=2132780 }}
*{{cite journal  | author=Kalies KU, Rapoport TA, Hartmann E |title=The beta subunit of the Sec61 complex facilitates cotranslational protein transport and interacts with the signal peptidase during translocation. |journal=J. Cell Biol. |volume=141 |issue= 4 |pages= 887-94 |year= 1998 |pmid= 9585408 |doi=  }}
*{{cite journal   |vauthors=Bebök Z, Mazzochi C, King SA, etal |title=The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the proteasome includes Sec61beta and a cytosolic, deglycosylated intermediary |journal=J. Biol. Chem. |volume=273 |issue= 45 |pages= 29873–8 |year= 1998 |pmid= 9792704 |doi=10.1074/jbc.273.45.29873 }}
*{{cite journal | author=Bebök Z, Mazzochi C, King SA, ''et al.'' |title=The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the proteasome includes Sec61beta and a cytosolic, deglycosylated intermediary. |journal=J. Biol. Chem. |volume=273 |issue= 45 |pages= 29873-8 |year= 1998 |pmid= 9792704 |doi= }}
*{{cite journal   |vauthors=Ingley E, Williams JH, Walker CE, etal |title=A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit |journal=FEBS Lett. |volume=459 |issue= 1 |pages= 69–74 |year= 1999 |pmid= 10508919 |doi=10.1016/S0014-5793(99)01188-6 }}
*{{cite journal  | author=Greenfield JJ, High S |title=The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment. |journal=J. Cell. Sci. |volume=112 ( Pt 10) |issue=  |pages= 1477-86 |year= 1999 |pmid= 10212142 |doi= }}
*{{cite journal   |vauthors=Yamaguchi A, Hori O, Stern DM, etal |title=Stress-Associated Endoplasmic Reticulum Protein 1 (Serp1)/Ribosome-Associated Membrane Protein 4 (Ramp4) Stabilizes Membrane Proteins during Stress and Facilitates Subsequent Glycosylation |journal=J. Cell Biol. |volume=147 |issue= 6 |pages= 1195–204 |year= 2000 |pmid= 10601334 |doi=10.1083/jcb.147.6.1195  | pmc=2168098 }}
*{{cite journal | author=Ingley E, Williams JH, Walker CE, ''et al.'' |title=A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit. |journal=FEBS Lett. |volume=459 |issue= 1 |pages= 69-74 |year= 1999 |pmid= 10508919 |doi=  }}
*{{cite journal   |vauthors=Meyer HA, Grau H, Kraft R, etal |title=Mammalian Sec61 is associated with Sec62 and Sec63 |journal=J. Biol. Chem. |volume=275 |issue= 19 |pages= 14550–7 |year= 2000 |pmid= 10799540 |doi=10.1074/jbc.275.19.14550 }}
*{{cite journal | author=Yamaguchi A, Hori O, Stern DM, ''et al.'' |title=Stress-associated endoplasmic reticulum protein 1 (SERP1)/Ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation. |journal=J. Cell Biol. |volume=147 |issue= 6 |pages= 1195-204 |year= 2000 |pmid= 10601334 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Meyer HA, Grau H, Kraft R, ''et al.'' |title=Mammalian Sec61 is associated with Sec62 and Sec63. |journal=J. Biol. Chem. |volume=275 |issue= 19 |pages= 14550-7 |year= 2000 |pmid= 10799540 |doi=  }}
*{{cite journal   |vauthors=Humphray SJ, Oliver K, Hunt AR, etal |title=DNA sequence and analysis of human chromosome 9 |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 | pmc=2734081 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Humphray SJ, Oliver K, Hunt AR, ''et al.'' |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369-74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 }}
*{{cite journal   |vauthors=Besemer J, Harant H, Wang S, etal |title=Selective inhibition of cotranslational translocation of vascular cell adhesion molecule 1 |journal=Nature |volume=436 |issue= 7048 |pages= 290–3 |year= 2005 |pmid= 16015337 |doi= 10.1038/nature03670 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Kim JE, Tannenbaum SR, White FM |title=Global phosphoproteome of HT-29 human colon adenocarcinoma cells |journal=J. Proteome Res. |volume=4 |issue= 4 |pages= 1339–46 |year= 2005 |pmid= 16083285 |doi= 10.1021/pr050048h }}
*{{cite journal | author=Besemer J, Harant H, Wang S, ''et al.'' |title=Selective inhibition of cotranslational translocation of vascular cell adhesion molecule 1. |journal=Nature |volume=436 |issue= 7048 |pages= 290-3 |year= 2005 |pmid= 16015337 |doi= 10.1038/nature03670 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Kim JE, Tannenbaum SR, White FM |title=Global phosphoproteome of HT-29 human colon adenocarcinoma cells. |journal=J. Proteome Res. |volume=4 |issue= 4 |pages= 1339-46 |year= 2005 |pmid= 16083285 |doi= 10.1021/pr050048h }}
*{{cite journal  | vauthors=Liao HJ, Carpenter G |title=Role of the Sec61 Translocon in EGF Receptor Trafficking to the Nucleus and Gene Expression |journal=Mol. Biol. Cell |volume=18 |issue= 3 |pages= 1064–72 |year= 2007 |pmid= 17215517 |doi= 10.1091/mbc.E06-09-0802 | pmc=1805100 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Liao HJ, Carpenter G |title=Role of the Sec61 translocon in EGF receptor trafficking to the nucleus and gene expression. |journal=Mol. Biol. Cell |volume=18 |issue= 3 |pages= 1064-72 |year= 2007 |pmid= 17215517 |doi= 10.1091/mbc.E06-09-0802 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
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{{gene-9-stub}}

Revision as of 06:04, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein transport protein Sec61 subunit beta is a protein that in humans is encoded by the SEC61B gene.[1][2][3]

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.[3]

References

  1. ↑ Hartmann E, Sommer T, Prehn S, Gorlich D, Jentsch S, Rapoport TA (Mar 1994). "Evolutionary conservation of components of the protein translocation complex". Nature. 367 (6464): 654–7. doi:10.1038/367654a0. PMID 8107851.
  2. ↑ Greenfield JJ, High S (Aug 1999). "The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment". J Cell Sci. 112 (10): 1477–86. PMID 10212142.
  3. ↑ 3.0 3.1 "Entrez Gene: SEC61B Sec61 beta subunit".

Further reading



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