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{{Infobox_gene}}
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'''Anaphase-promoting complex subunit 2''' is an [[enzyme]] that in humans is encoded by the ''ANAPC2'' [[gene]].<ref name="pmid11739784">{{cite journal | vauthors = Tang Z, Li B, Bharadwaj R, Zhu H, Ozkan E, Hakala K, Deisenhofer J, Yu H | title = APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex | journal = Mol Biol Cell | volume = 12 | issue = 12 | pages = 3839–51 |date=December 2001 | pmid = 11739784 | pmc = 60759 | doi = 10.1091/mbc.12.12.3839}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ANAPC2 anaphase promoting complex subunit 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29882| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
A large [[protein]] complex, termed the [[anaphase-promoting complex]] (APC), or the cyclosome, promotes [[metaphase]]-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S [[proteasome]]. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called [[cullin]]s, which may also be involved in [[ubiquitin]]-mediated degradation.<ref name="entrez"/>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Anaphase promoting complex subunit 2
| HGNCid = 19989
| Symbol = ANAPC2
| AltSymbols =; APC2; RP11-350O14.5
| OMIM = 606946
| ECnumber = 
| Homologene = 8359
| MGIid = 2139135
| GeneAtlas_image1 = PBB_GE_ANAPC2_218555_at_tn.png
| Function = {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein ligase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0000079 |text = regulation of cyclin-dependent protein kinase activity}} {{GNF_GO|id=GO:0000080 |text = G1 phase of mitotic cell cycle}} {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0008054 |text = cyclin catabolic process}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 29882
    | Hs_Ensembl = ENSG00000176248
    | Hs_RefseqProtein = XP_001130502
    | Hs_RefseqmRNA = XM_001130502
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 139189057
    | Hs_GenLoc_end = 139202878
    | Hs_Uniprot = Q9UJX6
    | Mm_EntrezGene = 99152
    | Mm_Ensembl = ENSMUSG00000026965
    | Mm_RefseqmRNA = NM_175300
    | Mm_RefseqProtein = NP_780509
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 25094508
    | Mm_GenLoc_end = 25107924
    | Mm_Uniprot = Q3TCK5
  }}
}}
'''Anaphase promoting complex subunit 2''', also known as '''ANAPC2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ANAPC2 anaphase promoting complex subunit 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29882| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==Interactions==
{{PBB_Summary
ANAPC2 has been shown to [[Protein-protein interaction|interact]] with [[ANAPC1]]<ref name=pmid12956947>{{cite journal |doi=10.1016/S0960-9822(03)00581-5 |last=Vodermaier |first=Hartmut C |last2=Gieffers |first2=Christian |last3=Maurer-Stroh |first3=Sebastian |last4=Eisenhaber |first4=Frank |last5=Peters |first5=Jan-Michael |date=September 2003  |title=TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1 |journal=Curr. Biol. |volume=13 |issue=17 |pages=1459–68 |publisher= |location = England| issn = 0960-9822| pmid = 12956947 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11076961>{{cite journal |doi=10.1083/jcb.151.4.749 |last=Sumara |first=I |author2=Vorlaufer E |author3=Gieffers C |author4=Peters B H |author5=Peters J M  |date=November 2000  |title=Characterization of vertebrate cohesin complexes and their regulation in prophase |journal=J. Cell Biol. |volume=151 |issue=4 |pages=749–62 |publisher= |location = UNITED STATES| issn = 0021-9525| pmid = 11076961 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2169443 }}</ref> and [[ANAPC11]].<ref name=pmid11739784 /><ref name=pmid10230407>{{cite journal |doi=10.1016/S1097-2765(00)80482-7 |last=Ohta |first=T |author2=Michel J J |author3=Schottelius A J |author4=Xiong Y  |date=April 1999  |title=ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity |journal=Mol. Cell |volume=3 |issue=4 |pages=535–41 |publisher= |location = UNITED STATES| issn = 1097-2765| pmid = 10230407 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
| section_title =  
| summary_text = A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation.<ref name="entrez">{{cite web | title = Entrez Gene: ANAPC2 anaphase promoting complex subunit 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29882| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|ANAPC2}}
* {{UCSC gene info|APC2}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Yu H, Peters JM, King RW, ''et al.'' |title=Identification of a cullin homology region in a subunit of the anaphase-promoting complex. |journal=Science |volume=279 |issue= 5354 |pages= 1219-22 |year= 1998 |pmid= 9469815 |doi=  }}
*{{cite journal  | vauthors=Yu H, Peters JM, King RW |title=Identification of a cullin homology region in a subunit of the anaphase-promoting complex. |journal=Science |volume=279 |issue= 5354 |pages= 1219–22 |year= 1998 |pmid= 9469815 |doi=10.1126/science.279.5354.1219 |display-authors=etal}}
*{{cite journal  | author=Grossberger R, Gieffers C, Zachariae W, ''et al.'' |title=Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex. |journal=J. Biol. Chem. |volume=274 |issue= 20 |pages= 14500-7 |year= 1999 |pmid= 10318877 |doi=  }}
*{{cite journal  | vauthors=Grossberger R, Gieffers C, Zachariae W |title=Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex. |journal=J. Biol. Chem. |volume=274 |issue= 20 |pages= 14500–7 |year= 1999 |pmid= 10318877 |doi=10.1074/jbc.274.20.14500 |display-authors=etal}}
*{{cite journal  | author=Gieffers C, Peters BH, Kramer ER, ''et al.'' |title=Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 20 |pages= 11317-22 |year= 1999 |pmid= 10500174 |doi=  }}
*{{cite journal  | vauthors=Gieffers C, Peters BH, Kramer ER |title=Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 20 |pages= 11317–22 |year= 1999 |pmid= 10500174 |doi=10.1073/pnas.96.20.11317  | pmc=18031 |display-authors=etal}}
*{{cite journal  | author=Nagase T, Kikuno R, Ishikawa KI, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 1 |pages= 65-73 |year= 2000 |pmid= 10718198 |doi=  }}
*{{cite journal  | vauthors=Nagase T, Kikuno R, Ishikawa KI |title=Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 1 |pages= 65–73 |year= 2000 |pmid= 10718198 |doi=10.1093/dnares/7.1.65 |display-authors=etal}}
*{{cite journal  | author=Gmachl M, Gieffers C, Podtelejnikov AV, ''et al.'' |title=The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 16 |pages= 8973-8 |year= 2000 |pmid= 10922056 |doi=  }}
*{{cite journal  | vauthors=Gmachl M, Gieffers C, Podtelejnikov AV |title=The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 16 |pages= 8973–8 |year= 2000 |pmid= 10922056 |doi=10.1073/pnas.97.16.8973  | pmc=16806 |display-authors=etal}}
*{{cite journal  | author=Jarrett CR, Blancato J, Cao T, ''et al.'' |title=Human APC2 localization and allelic imbalance. |journal=Cancer Res. |volume=61 |issue= 21 |pages= 7978-84 |year= 2001 |pmid= 11691822 |doi=  }}
*{{cite journal  | vauthors=Jarrett CR, Blancato J, Cao T |title=Human APC2 localization and allelic imbalance. |journal=Cancer Res. |volume=61 |issue= 21 |pages= 7978–84 |year= 2001 |pmid= 11691822 |doi=  |display-authors=etal}}
*{{cite journal  | author=Tang Z, Li B, Bharadwaj R, ''et al.'' |title=APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. |journal=Mol. Biol. Cell |volume=12 |issue= 12 |pages= 3839-51 |year= 2002 |pmid= 11739784 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Vodermaier HC, Gieffers C, Maurer-Stroh S |title=TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1. |journal=Curr. Biol. |volume=13 |issue= 17 |pages= 1459–68 |year= 2004 |pmid= 12956947 |doi=10.1016/S0960-9822(03)00581-5 |display-authors=etal}}
*{{cite journal  | author=Vodermaier HC, Gieffers C, Maurer-Stroh S, ''et al.'' |title=TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1. |journal=Curr. Biol. |volume=13 |issue= 17 |pages= 1459-68 |year= 2004 |pmid= 12956947 |doi=  }}
*{{cite journal  | vauthors=Capron A, Serralbo O, Fülöp K |title=The Arabidopsis anaphase-promoting complex or cyclosome: molecular and genetic characterization of the APC2 subunit. |journal=Plant Cell |volume=15 |issue= 10 |pages= 2370–82 |year= 2004 |pmid= 14508008 |doi= 10.1105/tpc.013847 | pmc=197302 |display-authors=etal}}
*{{cite journal  | author=Capron A, Serralbo O, Fülöp K, ''et al.'' |title=The Arabidopsis anaphase-promoting complex or cyclosome: molecular and genetic characterization of the APC2 subunit. |journal=Plant Cell |volume=15 |issue= 10 |pages= 2370-82 |year= 2004 |pmid= 14508008 |doi= 10.1105/tpc.013847 }}
*{{cite journal  | vauthors=Kraft C, Herzog F, Gieffers C |title=Mitotic regulation of the human anaphase-promoting complex by phosphorylation. |journal=EMBO J. |volume=22 |issue= 24 |pages= 6598–609 |year= 2004 |pmid= 14657031 |doi= 10.1093/emboj/cdg627 | pmc=291822 |display-authors=etal}}
*{{cite journal  | author=Kraft C, Herzog F, Gieffers C, ''et al.'' |title=Mitotic regulation of the human anaphase-promoting complex by phosphorylation. |journal=EMBO J. |volume=22 |issue= 24 |pages= 6598-609 |year= 2004 |pmid= 14657031 |doi= 10.1093/emboj/cdg627 }}
*{{cite journal  | vauthors=Humphray SJ, Oliver K, Hunt AR |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 | pmc=2734081 |display-authors=etal}}
*{{cite journal  | author=Humphray SJ, Oliver K, Hunt AR, ''et al.'' |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369-74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 }}
*{{cite journal  | vauthors=Colland F, Jacq X, Trouplin V |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 |display-authors=etal}}
*{{cite journal  | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | vauthors=Dube P, Herzog F, Gieffers C |title=Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. |journal=Mol. Cell |volume=20 |issue= 6 |pages= 867–79 |year= 2006 |pmid= 16364912 |doi= 10.1016/j.molcel.2005.11.008 |display-authors=etal}}
*{{cite journal  | author=Dube P, Herzog F, Gieffers C, ''et al.'' |title=Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. |journal=Mol. Cell |volume=20 |issue= 6 |pages= 867-79 |year= 2006 |pmid= 16364912 |doi= 10.1016/j.molcel.2005.11.008 }}
*{{cite journal  | vauthors=Beausoleil SA, Villén J, Gerber SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |display-authors=etal}}
*{{cite journal  | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 18:01, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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Anaphase-promoting complex subunit 2 is an enzyme that in humans is encoded by the ANAPC2 gene.[1][2]

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation.[2]

Interactions

ANAPC2 has been shown to interact with ANAPC1[3][4] and ANAPC11.[1][5]

References

  1. ↑ 1.0 1.1 Tang Z, Li B, Bharadwaj R, Zhu H, Ozkan E, Hakala K, Deisenhofer J, Yu H (December 2001). "APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex". Mol Biol Cell. 12 (12): 3839–51. doi:10.1091/mbc.12.12.3839. PMC 60759. PMID 11739784.
  2. ↑ 2.0 2.1 "Entrez Gene: ANAPC2 anaphase promoting complex subunit 2".
  3. ↑ Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. England. 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. ISSN 0960-9822. PMID 12956947.
  4. ↑ Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. UNITED STATES. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. ISSN 0021-9525. PMC 2169443. PMID 11076961.
  5. ↑ Ohta, T; Michel J J; Schottelius A J; Xiong Y (April 1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Mol. Cell. UNITED STATES. 3 (4): 535–41. doi:10.1016/S1097-2765(00)80482-7. ISSN 1097-2765. PMID 10230407.

External links

Further reading



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