DBC1: Difference between revisions

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Revision as of 18:15, 30 August 2017

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Deleted in bladder cancer protein 1 is a protein that in humans is encoded by the DBC1 gene.^[1]^[2]^[3]^[4]^[5]

This gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in transitional cell carcinoma of the bladder. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.^[3]

The functions of this gene are unknown, and it has not yet been placed in a protein family or functional pathway. Nonetheless, it is suspected to act as a tumor suppressor gene.

References

↑ Habuchi T, Yoshida O, Knowles MA (Jul 1997). "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum Mol Genet. 6 (6): 913–9. doi:10.1093/hmg/6.6.913. PMID 9175739.
↑ Nishiyama H, Hornigold N, Davies AM, Knowles MA (Nov 1999). "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics. 59 (3): 335–8. doi:10.1006/geno.1999.5891. PMID 10444335.
↑ ^3.0 ^3.1 "Entrez Gene: DBC1 deleted in bladder cancer 1".
↑ Habuchi T, Yoshida O, Knowles MA (June 1997). "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum. Mol. Genet. 6 (6): 913–9. doi:10.1093/hmg/6.6.913. PMID 9175739.
↑ Nishiyama H, Hornigold N, Davies AM, Knowles MA (August 1999). "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics. 59 (3): 335–8. doi:10.1006/geno.1999.5891. PMID 10444335.

Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". C. R. Acad. Sci. III, Sci. Vie. 318 (2): 263–72. PMID 7757816.
Habuchi T, Luscombe M, Elder PA, Knowles MA (1998). "Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33". Genomics. 48 (3): 277–88. doi:10.1006/geno.1997.5165. PMID 9545632.
Nishiyama H, Takahashi T, Kakehi Y, et al. (2000). "Homozygous deletion at the 9q32-33 candidate tumor suppressor locus in primary human bladder cancer". Genes Chromosomes Cancer. 26 (2): 171–5. doi:10.1002/(SICI)1098-2264(199910)26:2<171::AID-GCC10>3.0.CO;2-B. PMID 10469456.
Nishiyama H, Gill JH, Pitt E, et al. (2001). "Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1". Oncogene. 20 (23): 2956–64. doi:10.1038/sj.onc.1204432. PMID 11420708.
Wright KO, Messing EM, Reeder JE (2002). "Increased expression of the acid sphingomyelinase-like protein ASML3a in bladder tumors". J. Urol. 168 (6): 2645–9. doi:10.1097/01.ju.0000037848.19383.88. PMID 12442002.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wright KO, Messing EM, Reeder JE (2004). "DBCCR1 mediates death in cultured bladder tumor cells". Oncogene. 23 (1): 82–90. doi:10.1038/sj.onc.1206642. PMID 14712213.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beetz C, Brodoehl S, Patt S, et al. (2005). "Low expression but infrequent genomic loss of the putative tumour suppressor DBCCR1 in astrocytoma". Oncol. Rep. 13 (2): 335–40. doi:10.3892/or.13.2.335. PMID 15643521.
Izumi H, Inoue J, Yokoi S, et al. (2005). "Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers". Hum. Mol. Genet. 14 (8): 997–1007. doi:10.1093/hmg/ddi092. PMID 15746151.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Louhelainen JP, Hurst CD, Pitt E, et al. (2006). "DBC1 re-expression alters the expression of multiple components of the plasminogen pathway". Oncogene. 25 (16): 2409–19. doi:10.1038/sj.onc.1209228. PMID 16369496.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[pmid9175739-1] Habuchi T, Yoshida O, Knowles MA (Jul 1997). "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum Mol Genet. 6 (6): 913–9. doi:10.1093/hmg/6.6.913. PMID 9175739.

[pmid10444335-2] Nishiyama H, Hornigold N, Davies AM, Knowles MA (Nov 1999). "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics. 59 (3): 335–8. doi:10.1006/geno.1999.5891. PMID 10444335.

[entrez-3] 3.0 ^3.1 "Entrez Gene: DBC1 deleted in bladder cancer 1".

[autogenerated1-4] Habuchi T, Yoshida O, Knowles MA (June 1997). "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum. Mol. Genet. 6 (6): 913–9. doi:10.1093/hmg/6.6.913. PMID 9175739.

[autogenerated2-5] Nishiyama H, Hornigold N, Davies AM, Knowles MA (August 1999). "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics. 59 (3): 335–8. doi:10.1006/geno.1999.5891. PMID 10444335.

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[4]

[5]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Distinguish2|[[KIAA1967|Deleted in Breast Cancer 1 (DBC1)]]}}
-{{PBB_Controls
+{{Infobox_gene}}
-| update_page = yes
+'''Deleted in bladder cancer protein 1''' is a [[protein]] that in humans is encoded by the ''DBC1'' [[gene]].<ref name="pmid9175739">{{cite journal | vauthors = Habuchi T, Yoshida O, Knowles MA | title = A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC | journal = Hum Mol Genet | volume = 6 | issue = 6 | pages = 913–9 |date=Jul 1997 | pmid = 9175739 | pmc =  | doi =10.1093/hmg/6.6.913  }}</ref><ref name="pmid10444335">{{cite journal | vauthors = Nishiyama H, Hornigold N, Davies AM, Knowles MA | title = A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33 | journal = Genomics | volume = 59 | issue = 3 | pages = 335–8 |date=Nov 1999 | pmid = 10444335 | pmc =  | doi = 10.1006/geno.1999.5891 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DBC1 deleted in bladder cancer 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1620| accessdate = }}</ref><ref name=autogenerated1>{{cite journal | vauthors = Habuchi T, Yoshida O, Knowles MA | title = A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC | journal = Hum. Mol. Genet. | volume = 6 | issue = 6 | pages = 913–9 |date=June 1997 | pmid = 9175739 | doi = 10.1093/hmg/6.6.913 | url =   }}</ref><ref name=autogenerated2>{{cite journal | vauthors = Nishiyama H, Hornigold N, Davies AM, Knowles MA | title = A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33 | journal = Genomics | volume = 59 | issue = 3 | pages = 335–8 |date=August 1999 | pmid = 10444335 | doi = 10.1006/geno.1999.5891 | url =  }}</ref>
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-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+This gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in [[transitional cell carcinoma]] of the bladder.  It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.<ref name="entrez" />
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Deleted in bladder cancer 1
- | HGNCid = 2687
- | Symbol = DBC1
- | AltSymbols =; DBCCR1; FAM5A
- | OMIM = 602865
- | ECnumber =
- | Homologene = 8754
- | MGIid = 1928478
- | GeneAtlas_image1 = PBB_GE_DBC1_205818_at_tn.png
-  | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
- | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
- | Process = {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0008219 |text = cell death}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 1620
-    | Hs_Ensembl = ENSG00000078725
-    | Hs_RefseqProtein = NP_055433
-    | Hs_RefseqmRNA = NM_014618
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 9
-    | Hs_GenLoc_start = 120968728
-    | Hs_GenLoc_end = 121171566
-    | Hs_Uniprot = O60477
-    | Mm_EntrezGene = 56710
-    | Mm_Ensembl = ENSMUSG00000028351
-    | Mm_RefseqmRNA = NM_019967
-    | Mm_RefseqProtein = NP_064351
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 4
-    | Mm_GenLoc_start = 68247733
-    | Mm_GenLoc_end = 68440758
-    | Mm_Uniprot = Q920P3
-  }}
-}}
-'''Deleted in bladder cancer 1''', also known as '''DBC1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DBC1 deleted in bladder cancer 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1620| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+The functions of this gene are unknown, and it has not yet been placed in a protein family or functional pathway. Nonetheless, it is suspected to act as a [[tumor suppressor gene]].
-{{PBB_Summary
-| section_title =
-| summary_text = This gene is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers.  It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.<ref name="entrez">{{cite web | title = Entrez Gene: DBC1 deleted in bladder cancer 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1620| accessdate = }}</ref>
-}}
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Auffray C, Behar G, Bois F, ''et al.'' |title=[IMAGE: molecular integration of the analysis of the human genome and its expression] |journal=C. R. Acad. Sci. III, Sci. Vie |volume=318 |issue= 2 |pages= 263-72 |year= 1995 |pmid= 7757816 |doi=  }}
+*{{cite journal  | vauthors=Auffray C, Behar G, Bois F |title=[IMAGE: molecular integration of the analysis of the human genome and its expression] |journal=C. R. Acad. Sci. III, Sci. Vie |volume=318 |issue= 2 |pages= 263–72 |year= 1995 |pmid= 7757816 |doi=  |display-authors=etal}}
-*{{cite journal  | author=Habuchi T, Yoshida O, Knowles MA |title=A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC. |journal=Hum. Mol. Genet. |volume=6 |issue= 6 |pages= 913-9 |year= 1997 |pmid= 9175739 |doi=  }}
+*{{cite journal  | vauthors=Habuchi T, Luscombe M, Elder PA, Knowles MA |title=Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33. |journal=Genomics |volume=48 |issue= 3 |pages= 277–88 |year= 1998 |pmid= 9545632 |doi= 10.1006/geno.1997.5165 }}
-*{{cite journal  | author=Habuchi T, Luscombe M, Elder PA, Knowles MA |title=Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33. |journal=Genomics |volume=48 |issue= 3 |pages= 277-88 |year= 1998 |pmid= 9545632 |doi= 10.1006/geno.1997.5165 }}
+*{{cite journal  | vauthors=Nishiyama H, Takahashi T, Kakehi Y |title=Homozygous deletion at the 9q32-33 candidate tumor suppressor locus in primary human bladder cancer. |journal=Genes Chromosomes Cancer |volume=26 |issue= 2 |pages= 171–5 |year= 2000 |pmid= 10469456 |doi=10.1002/(SICI)1098-2264(199910)26:2<171::AID-GCC10>3.0.CO;2-B  |display-authors=etal}}
-*{{cite journal  | author=Nishiyama H, Hornigold N, Davies AM, Knowles MA |title=A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33. |journal=Genomics |volume=59 |issue= 3 |pages= 335-8 |year= 1999 |pmid= 10444335 |doi= 10.1006/geno.1999.5891 }}
+*{{cite journal  | vauthors=Nishiyama H, Gill JH, Pitt E |title=Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1. |journal=Oncogene |volume=20 |issue= 23 |pages= 2956–64 |year= 2001 |pmid= 11420708 |doi= 10.1038/sj.onc.1204432 |display-authors=etal}}
-*{{cite journal  | author=Nishiyama H, Takahashi T, Kakehi Y, ''et al.'' |title=Homozygous deletion at the 9q32-33 candidate tumor suppressor locus in primary human bladder cancer. |journal=Genes Chromosomes Cancer |volume=26 |issue= 2 |pages= 171-5 |year= 2000 |pmid= 10469456 |doi=  }}
+*{{cite journal  | vauthors=Wright KO, Messing EM, Reeder JE |title=Increased expression of the acid sphingomyelinase-like protein ASML3a in bladder tumors. |journal=J. Urol. |volume=168 |issue= 6 |pages= 2645–9 |year= 2002 |pmid= 12442002 |doi= 10.1097/01.ju.0000037848.19383.88 }}
-*{{cite journal  | author=Nishiyama H, Gill JH, Pitt E, ''et al.'' |title=Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1. |journal=Oncogene |volume=20 |issue= 23 |pages= 2956-64 |year= 2001 |pmid= 11420708 |doi= 10.1038/sj.onc.1204432 }}
+*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Wright KO, Messing EM, Reeder JE |title=Increased expression of the acid sphingomyelinase-like protein ASML3a in bladder tumors. |journal=J. Urol. |volume=168 |issue= 6 |pages= 2645-9 |year= 2002 |pmid= 12442002 |doi= 10.1097/01.ju.0000037848.19383.88 }}
+*{{cite journal  | vauthors=Wright KO, Messing EM, Reeder JE |title=DBCCR1 mediates death in cultured bladder tumor cells. |journal=Oncogene |volume=23 |issue= 1 |pages= 82–90 |year= 2004 |pmid= 14712213 |doi= 10.1038/sj.onc.1206642 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | vauthors=Humphray SJ, Oliver K, Hunt AR |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465  | pmc=2734081 |display-authors=etal}}
-*{{cite journal  | author=Wright KO, Messing EM, Reeder JE |title=DBCCR1 mediates death in cultured bladder tumor cells. |journal=Oncogene |volume=23 |issue= 1 |pages= 82-90 |year= 2004 |pmid= 14712213 |doi= 10.1038/sj.onc.1206642 }}
+*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
-*{{cite journal  | author=Humphray SJ, Oliver K, Hunt AR, ''et al.'' |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369-74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 }}
+*{{cite journal  | vauthors=Beetz C, Brodoehl S, Patt S |title=Low expression but infrequent genomic loss of the putative tumour suppressor DBCCR1 in astrocytoma. |journal=Oncol. Rep. |volume=13 |issue= 2 |pages= 335–40 |year= 2005 |pmid= 15643521 |doi=  10.3892/or.13.2.335|display-authors=etal}}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal  | vauthors=Izumi H, Inoue J, Yokoi S |title=Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers. |journal=Hum. Mol. Genet. |volume=14 |issue= 8 |pages= 997–1007 |year= 2005 |pmid= 15746151 |doi= 10.1093/hmg/ddi092 |display-authors=etal}}
-*{{cite journal  | author=Beetz C, Brodoehl S, Patt S, ''et al.'' |title=Low expression but infrequent genomic loss of the putative tumour suppressor DBCCR1 in astrocytoma. |journal=Oncol. Rep. |volume=13 |issue= 2 |pages= 335-40 |year= 2005 |pmid= 15643521 |doi=  }}
+*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
-*{{cite journal  | author=Izumi H, Inoue J, Yokoi S, ''et al.'' |title=Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers. |journal=Hum. Mol. Genet. |volume=14 |issue= 8 |pages= 997-1007 |year= 2005 |pmid= 15746151 |doi= 10.1093/hmg/ddi092 }}
+*{{cite journal  | vauthors=Louhelainen JP, Hurst CD, Pitt E |title=DBC1 re-expression alters the expression of multiple components of the plasminogen pathway. |journal=Oncogene |volume=25 |issue= 16 |pages= 2409–19 |year= 2006 |pmid= 16369496 |doi= 10.1038/sj.onc.1209228 |display-authors=etal}}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
-*{{cite journal  | author=Louhelainen JP, Hurst CD, Pitt E, ''et al.'' |title=DBC1 re-expression alters the expression of multiple components of the plasminogen pathway. |journal=Oncogene |volume=25 |issue= 16 |pages= 2409-19 |year= 2006 |pmid= 16369496 |doi= 10.1038/sj.onc.1209228 }}
 }}
 {{refend}}
-{{protein-stub}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
-{{WikiDoc Sources}}
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = no
+| update_citations = yes
+}}
+{{gene-9-stub}}

DBC1: Difference between revisions

Revision as of 18:15, 30 August 2017

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