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{{Infobox_gene}}
{{PBB_Controls
'''SECIS-binding protein 2''' (commonly referred to as '''SBP2''') is a [[protein]] that in humans is encoded by the ''SECISBP2'' [[gene]].<ref name="pmid11230166">{{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = March 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SECISBP2 SECIS binding protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79048| accessdate = }}</ref>
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| update_protein_box = yes
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = SECIS binding protein 2
| HGNCid = 30972
| Symbol = SECISBP2
| AltSymbols =; DKFZp686C09169; SBP2
| OMIM = 607693
| ECnumber = 
| Homologene = 11415
| MGIid = 1922670
| GeneAtlas_image1 = PBB_GE_SECISBP2_218265_at_tn.png
| Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006412 |text = translation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 79048
    | Hs_Ensembl = ENSG00000187742
    | Hs_RefseqProtein = NP_076982
    | Hs_RefseqmRNA = NM_024077
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 91123241
    | Hs_GenLoc_end = 91164377
    | Hs_Uniprot = Q96T21
    | Mm_EntrezGene = 75420
    | Mm_Ensembl = ENSMUSG00000035139
    | Mm_RefseqmRNA = XM_127336
    | Mm_RefseqProtein = XP_127336
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 51664267
    | Mm_GenLoc_end = 51696341
    | Mm_Uniprot = 
  }}
}}
'''SECIS binding protein 2''', also known as '''SECISBP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SECISBP2 SECIS binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79048| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The incorporation of [[selenocysteine]] into a protein requires the concerted action of an mRNA element called a sec insertion sequence ([[SECIS element|SECIS]]), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. SBP2 is a nuclear protein that functions as a SECIS binding protein, but experimental evidence indicates that SBP2 is cytoplasmic.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism.<ref name="entrez">{{cite web | title = Entrez Gene: SECISBP2 SECIS binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79048| accessdate = }}</ref>
}}


==See also==
== Clinical significance ==
 
Mutations in this gene have been associated with a reduction in activity of a specific thyroxine [[deiodinase]], a selenocysteine-containing enzyme, and abnormal [[thyroid hormone]] metabolism.<ref name="entrez" />
 
== See also ==
* [[Thyroid hormone resistance]]
* [[Thyroid hormone resistance]]


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
{{-}}
{{refbegin | 2}}
== Further reading ==
{{PBB_Further_reading
{{refbegin|33em}}
| citations =
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Copeland PR, Fletcher JE, Carlson BA, Hatfield DL, Driscoll DM | title = A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs | journal = The EMBO Journal | volume = 19 | issue = 2 | pages = 306–14 | date = January 2000 | pmid = 10637234 | pmc = 305564 | doi = 10.1093/emboj/19.2.306 }}
*{{cite journal | author=Copeland PR, Fletcher JE, Carlson BA, ''et al.'' |title=A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs. |journal=EMBO J. |volume=19 |issue= 2 |pages= 306-14 |year= 2000 |pmid= 10637234 |doi= 10.1093/emboj/19.2.306 }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = November 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
* {{cite journal | vauthors = Low SC, Grundner-Culemann E, Harney JW, Berry MJ | title = SECIS-SBP2 interactions dictate selenocysteine incorporation efficiency and selenoprotein hierarchy | journal = The EMBO Journal | volume = 19 | issue = 24 | pages = 6882–90 | date = December 2000 | pmid = 11118223 | pmc = 305907 | doi = 10.1093/emboj/19.24.6882 }}
*{{cite journal | author=Low SC, Grundner-Culemann E, Harney JW, Berry MJ |title=SECIS-SBP2 interactions dictate selenocysteine incorporation efficiency and selenoprotein hierarchy. |journal=EMBO J. |volume=19 |issue= 24 |pages= 6882-90 |year= 2001 |pmid= 11118223 |doi= 10.1093/emboj/19.24.6882 }}
* {{cite journal | vauthors = Lescure A, Allmang C, Yamada K, Carbon P, Krol A | title = cDNA cloning, expression pattern and RNA binding analysis of human selenocysteine insertion sequence (SECIS) binding protein 2 | journal = Gene | volume = 291 | issue = 1-2 | pages = 279–85 | date = May 2002 | pmid = 12095701 | doi = 10.1016/S0378-1119(02)00629-7 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
* {{cite journal | vauthors = Allmang C, Carbon P, Krol A | title = The SBP2 and 15.5 kD/Snu13p proteins share the same RNA binding domain: identification of SBP2 amino acids important to SECIS RNA binding | journal = Rna | volume = 8 | issue = 10 | pages = 1308–18 | date = October 2002 | pmid = 12403468 | pmc = 1370339 | doi = 10.1017/S1355838202020034 }}
*{{cite journal  | author=Lescure A, Allmang C, Yamada K, ''et al.'' |title=cDNA cloning, expression pattern and RNA binding analysis of human selenocysteine insertion sequence (SECIS) binding protein 2. |journal=Gene |volume=291 |issue= 1-2 |pages= 279-85 |year= 2002 |pmid= 12095701 |doi= }}
* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–44 | date = October 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
*{{cite journal | author=Allmang C, Carbon P, Krol A |title=The SBP2 and 15.5 kD/Snu13p proteins share the same RNA binding domain: identification of SBP2 amino acids important to SECIS RNA binding. |journal=RNA |volume=8 |issue= 10 |pages= 1308-18 |year= 2002 |pmid= 12403468 |doi= }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Dumitrescu AM, Liao XH, Abdullah MS, Lado-Abeal J, Majed FA, Moeller LC, Boran G, Schomburg L, Weiss RE, Refetoff S | title = Mutations in SECISBP2 result in abnormal thyroid hormone metabolism | journal = Nature Genetics | volume = 37 | issue = 11 | pages = 1247–52 | date = November 2005 | pmid = 16228000 | doi = 10.1038/ng1654 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | title = The LIFEdb database in 2006 | journal = Nucleic Acids Research | volume = 34 | issue = Database issue | pages = D415-8 | date = January 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Papp LV, Lu J, Striebel F, Kennedy D, Holmgren A, Khanna KK | title = The redox state of SECIS binding protein 2 controls its localization and selenocysteine incorporation function | journal = Molecular and Cellular Biology | volume = 26 | issue = 13 | pages = 4895–910 | date = July 2006 | pmid = 16782878 | pmc = 1489162 | doi = 10.1128/MCB.02284-05 }}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Dumitrescu AM, Liao XH, Abdullah MS, ''et al.'' |title=Mutations in SECISBP2 result in abnormal thyroid hormone metabolism. |journal=Nat. Genet. |volume=37 |issue= 11 |pages= 1247-52 |year= 2006 |pmid= 16228000 |doi= 10.1038/ng1654 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal | author=Papp LV, Lu J, Striebel F, ''et al.'' |title=The redox state of SECIS binding protein 2 controls its localization and selenocysteine incorporation function. |journal=Mol. Cell. Biol. |volume=26 |issue= 13 |pages= 4895-910 |year= 2006 |pmid= 16782878 |doi= 10.1128/MCB.02284-05 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
[[Category:Selenoproteins]]
{{WikiDoc Sources}}
 
{{gene-9-stub}}

Revision as of 06:04, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

SECIS-binding protein 2 (commonly referred to as SBP2) is a protein that in humans is encoded by the SECISBP2 gene.[1][2]

Function

The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. SBP2 is a nuclear protein that functions as a SECIS binding protein, but experimental evidence indicates that SBP2 is cytoplasmic.[2]

Clinical significance

Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism.[2]

See also

References

  1. ↑ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  2. ↑ 2.0 2.1 2.2 "Entrez Gene: SECISBP2 SECIS binding protein 2".

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=SECISBP2&oldid=1422719"