MAGEA4: Difference between revisions

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{{Infobox_gene}}
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'''Melanoma-associated antigen 4''' is a [[protein]] that in humans is encoded by the ''MAGEA4'' [[gene]].<ref name="pmid8575766">{{cite journal |vauthors=Rogner UC, Wilke K, Steck E, Korn B, Poustka A | title = The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28 | journal = Genomics | volume = 29 | issue = 3 | pages = 725–31 |date=Mar 1996 | pmid = 8575766 | pmc =  | doi = 10.1006/geno.1995.9945 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAGEA4 melanoma antigen family A, 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4103| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Melanoma antigen family A, 4
| HGNCid = 6802
| Symbol = MAGEA4
| AltSymbols =; MAGE-41; MAGE-X2; MAGE4; MAGE4A; MAGE4B; MGC21336
| OMIM = 300175
| ECnumber =
| Homologene = 74435
| MGIid = 1350986
  | GeneAtlas_image1 = PBB_GE_MAGEA4_214254_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}}  
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}}
| Process = {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4103
    | Hs_Ensembl = ENSG00000147381
    | Hs_RefseqProtein = NP_001011548
    | Hs_RefseqmRNA = NM_001011548
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 150831652
    | Hs_GenLoc_end = 150844298
    | Hs_Uniprot = P43358
    | Mm_EntrezGene = 195772
    | Mm_Ensembl = ENSMUSG00000046301
    | Mm_RefseqmRNA = NM_181855
    | Mm_RefseqProtein = NP_862903
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 69122087
    | Mm_GenLoc_end = 69122818
    | Mm_Uniprot = 
  }}
}}
'''Melanoma antigen family A, 4''', also known as '''MAGEA4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAGEA4 melanoma antigen family A, 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4103| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: MAGEA4 melanoma antigen family A, 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4103| accessdate = }}</ref>
| summary_text = This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as [[dyskeratosis congenita]]. At least four variants encoding the same protein have been found for this gene.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Brasseur F, Rimoldi D, Liénard D, ''et al.'' |title=Expression of MAGE genes in primary and metastatic cutaneous melanoma. |journal=Int. J. Cancer |volume=63 |issue= 3 |pages= 375-80 |year= 1995 |pmid= 7591235 |doi=  }}
*{{cite journal   |vauthors=Brasseur F, Rimoldi D, Liénard D, etal |title=Expression of MAGE genes in primary and metastatic cutaneous melanoma. |journal=Int. J. Cancer |volume=63 |issue= 3 |pages= 375–80 |year= 1995 |pmid= 7591235 |doi=10.1002/ijc.2910630313 }}
*{{cite journal | author=Imai Y, Shichijo S, Yamada A, ''et al.'' |title=Sequence analysis of the MAGE gene family encoding human tumor-rejection antigens. |journal=Gene |volume=160 |issue= 2 |pages= 287-90 |year= 1995 |pmid= 7642112 |doi=  }}
*{{cite journal   |vauthors=Imai Y, Shichijo S, Yamada A, etal |title=Sequence analysis of the MAGE gene family encoding human tumor-rejection antigens. |journal=Gene |volume=160 |issue= 2 |pages= 287–90 |year= 1995 |pmid= 7642112 |doi=10.1016/0378-1119(94)00680-Q }}
*{{cite journal | author=De Plaen E, Arden K, Traversari C, ''et al.'' |title=Structure, chromosomal localization, and expression of 12 genes of the MAGE family. |journal=Immunogenetics |volume=40 |issue= 5 |pages= 360-9 |year= 1994 |pmid= 7927540 |doi=  }}
*{{cite journal   |vauthors=De Plaen E, Arden K, Traversari C, etal |title=Structure, chromosomal localization, and expression of 12 genes of the MAGE family. |journal=Immunogenetics |volume=40 |issue= 5 |pages= 360–9 |year= 1994 |pmid= 7927540 |doi=10.1007/BF01246677 }}
*{{cite journal  | author=Ding M, Beck RJ, Keller CJ, Fenton RG |title=Cloning and analysis of MAGE-1-related genes. |journal=Biochem. Biophys. Res. Commun. |volume=202 |issue= 1 |pages= 549-55 |year= 1994 |pmid= 8037761 |doi= 10.1006/bbrc.1994.1963 }}
*{{cite journal  |vauthors=Ding M, Beck RJ, Keller CJ, Fenton RG |title=Cloning and analysis of MAGE-1-related genes. |journal=Biochem. Biophys. Res. Commun. |volume=202 |issue= 1 |pages= 549–55 |year= 1994 |pmid= 8037761 |doi= 10.1006/bbrc.1994.1963 }}
*{{cite journal | author=Rogner UC, Wilke K, Steck E, ''et al.'' |title=The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. |journal=Genomics |volume=29 |issue= 3 |pages= 725-31 |year= 1996 |pmid= 8575766 |doi= 10.1006/geno.1995.9945 }}
*{{cite journal   |vauthors=De Plaen E, Naerhuyzen B, De Smet C, etal |title=Alternative promoters of gene MAGE4a. |journal=Genomics |volume=40 |issue= 2 |pages= 305–13 |year= 1997 |pmid= 9119398 |doi= 10.1006/geno.1996.4566 }}
*{{cite journal | author=De Plaen E, Naerhuyzen B, De Smet C, ''et al.'' |title=Alternative promoters of gene MAGE4a. |journal=Genomics |volume=40 |issue= 2 |pages= 305-13 |year= 1997 |pmid= 9119398 |doi= 10.1006/geno.1996.4566 }}
*{{cite journal   |vauthors=Hillig RC, Coulie PG, Stroobant V, etal |title=High-resolution structure of HLA-A*0201 in complex with a tumour-specific antigenic peptide encoded by the MAGE-A4 gene. |journal=J. Mol. Biol. |volume=310 |issue= 5 |pages= 1167–76 |year= 2001 |pmid= 11502003 |doi= 10.1006/jmbi.2001.4816 }}
*{{cite journal | author=Hillig RC, Coulie PG, Stroobant V, ''et al.'' |title=High-resolution structure of HLA-A*0201 in complex with a tumour-specific antigenic peptide encoded by the MAGE-A4 gene. |journal=J. Mol. Biol. |volume=310 |issue= 5 |pages= 1167-76 |year= 2001 |pmid= 11502003 |doi= 10.1006/jmbi.2001.4816 }}
*{{cite journal   |vauthors=Yutani S, Tanaka M, Mutsumoto H, etal |title=Elevation of serum MAGE-4 protein levels and prediction of hepatocellular carcinogenesis in patients with liver cirrhosis. |journal=Jpn. J. Cancer Res. |volume=93 |issue= 4 |pages= 453–8 |year= 2005 |pmid= 11985796 |doi= 10.1111/j.1349-7006.2002.tb01277.x }}
*{{cite journal | author=Yutani S, Tanaka M, Mutsumoto H, ''et al.'' |title=Elevation of serum MAGE-4 protein levels and prediction of hepatocellular carcinogenesis in patients with liver cirrhosis. |journal=Jpn. J. Cancer Res. |volume=93 |issue= 4 |pages= 453-8 |year= 2005 |pmid= 11985796 |doi= }}
*{{cite journal   |vauthors=Kocher T, Zheng M, Bolli M, etal |title=Prognostic relevance of MAGE-A4 tumor antigen expression in transitional cell carcinoma of the urinary bladder: a tissue microarray study. |journal=Int. J. Cancer |volume=100 |issue= 6 |pages= 702–5 |year= 2002 |pmid= 12209610 |doi= 10.1002/ijc.10540 }}
*{{cite journal | author=Kocher T, Zheng M, Bolli M, ''et al.'' |title=Prognostic relevance of MAGE-A4 tumor antigen expression in transitional cell carcinoma of the urinary bladder: a tissue microarray study. |journal=Int. J. Cancer |volume=100 |issue= 6 |pages= 702-5 |year= 2002 |pmid= 12209610 |doi= 10.1002/ijc.10540 }}
*{{cite journal   |vauthors=Resnick MB, Sabo E, Kondratev S, etal |title=Cancer-testis antigen expression in uterine malignancies with an emphasis on carcinosarcomas and papillary serous carcinomas. |journal=Int. J. Cancer |volume=101 |issue= 2 |pages= 190–5 |year= 2002 |pmid= 12209997 |doi= 10.1002/ijc.10585 }}
*{{cite journal | author=Resnick MB, Sabo E, Kondratev S, ''et al.'' |title=Cancer-testis antigen expression in uterine malignancies with an emphasis on carcinosarcomas and papillary serous carcinomas. |journal=Int. J. Cancer |volume=101 |issue= 2 |pages= 190-5 |year= 2002 |pmid= 12209997 |doi= 10.1002/ijc.10585 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Nagao T, Higashitsuji H, Nonoguchi K, etal |title=MAGE-A4 interacts with the liver oncoprotein gankyrin and suppresses its tumorigenic activity. |journal=J. Biol. Chem. |volume=278 |issue= 12 |pages= 10668–74 |year= 2003 |pmid= 12525503 |doi= 10.1074/jbc.M206104200 }}
*{{cite journal | author=Nagao T, Higashitsuji H, Nonoguchi K, ''et al.'' |title=MAGE-A4 interacts with the liver oncoprotein gankyrin and suppresses its tumorigenic activity. |journal=J. Biol. Chem. |volume=278 |issue= 12 |pages= 10668-74 |year= 2003 |pmid= 12525503 |doi= 10.1074/jbc.M206104200 }}
*{{cite journal   |vauthors=Sarcevic B, Spagnoli GC, Terracciano L, etal |title=Expression of cancer/testis tumor associated antigens in cervical squamous cell carcinoma. |journal=Oncology |volume=64 |issue= 4 |pages= 443–9 |year= 2003 |pmid= 12759544 |doi= 10.1159/000070305 }}
*{{cite journal | author=Sarcevic B, Spagnoli GC, Terracciano L, ''et al.'' |title=Expression of cancer/testis tumor associated antigens in cervical squamous cell carcinoma. |journal=Oncology |volume=64 |issue= 4 |pages= 443-9 |year= 2003 |pmid= 12759544 |doi= 10.1159/000070305 }}
*{{cite journal   |vauthors=Sakurai T, Itoh K, Higashitsuji H, etal |title=A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells. |journal=J. Biol. Chem. |volume=279 |issue= 15 |pages= 15505–14 |year= 2004 |pmid= 14739298 |doi= 10.1074/jbc.M310437200 }}
*{{cite journal | author=Sakurai T, Itoh K, Higashitsuji H, ''et al.'' |title=A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells. |journal=J. Biol. Chem. |volume=279 |issue= 15 |pages= 15505-14 |year= 2004 |pmid= 14739298 |doi= 10.1074/jbc.M310437200 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Miyahara Y, Naota H, Wang L, etal |title=Determination of cellularly processed HLA-A2402-restricted novel CTL epitopes derived from two cancer germ line genes, MAGE-A4 and SAGE. |journal=Clin. Cancer Res. |volume=11 |issue= 15 |pages= 5581–9 |year= 2006 |pmid= 16061876 |doi= 10.1158/1078-0432.CCR-04-2585 }}
*{{cite journal | author=Miyahara Y, Naota H, Wang L, ''et al.'' |title=Determination of cellularly processed HLA-A2402-restricted novel CTL epitopes derived from two cancer germ line genes, MAGE-A4 and SAGE. |journal=Clin. Cancer Res. |volume=11 |issue= 15 |pages= 5581-9 |year= 2006 |pmid= 16061876 |doi= 10.1158/1078-0432.CCR-04-2585 }}
*{{cite journal   |vauthors=Hudolin T, Juretic A, Spagnoli GC, etal |title=Immunohistochemical expression of tumor antigens MAGE-A1, MAGE-A3/4, and NY-ESO-1 in cancerous and benign prostatic tissue. |journal=Prostate |volume=66 |issue= 1 |pages= 13–8 |year= 2006 |pmid= 16114059 |doi= 10.1002/pros.20312 }}
*{{cite journal | author=Hudolin T, Juretic A, Spagnoli GC, ''et al.'' |title=Immunohistochemical expression of tumor antigens MAGE-A1, MAGE-A3/4, and NY-ESO-1 in cancerous and benign prostatic tissue. |journal=Prostate |volume=66 |issue= 1 |pages= 13-8 |year= 2006 |pmid= 16114059 |doi= 10.1002/pros.20312 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Yoshida N, Abe H, Ohkuri T, etal |title=Expression of the MAGE-A4 and NY-ESO-1 cancer-testis antigens and T cell infiltration in non-small cell lung carcinoma and their prognostic significance. |journal=Int. J. Oncol. |volume=28 |issue= 5 |pages= 1089–98 |year= 2006 |pmid= 16596224 |doi= 10.3892/ijo.28.5.1089}}
*{{cite journal  | author=Yoshida N, Abe H, Ohkuri T, ''et al.'' |title=Expression of the MAGE-A4 and NY-ESO-1 cancer-testis antigens and T cell infiltration in non-small cell lung carcinoma and their prognostic significance. |journal=Int. J. Oncol. |volume=28 |issue= 5 |pages= 1089-98 |year= 2006 |pmid= 16596224 |doi=  }}
*{{cite journal   |vauthors=Peikert T, Specks U, Farver C, etal |title=Melanoma antigen A4 is expressed in non-small cell lung cancers and promotes apoptosis. |journal=Cancer Res. |volume=66 |issue= 9 |pages= 4693–700 |year= 2006 |pmid= 16651421 |doi= 10.1158/0008-5472.CAN-05-3327 }}
*{{cite journal | author=Peikert T, Specks U, Farver C, ''et al.'' |title=Melanoma antigen A4 is expressed in non-small cell lung cancers and promotes apoptosis. |journal=Cancer Res. |volume=66 |issue= 9 |pages= 4693-700 |year= 2006 |pmid= 16651421 |doi= 10.1158/0008-5472.CAN-05-3327 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 06:01, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Melanoma-associated antigen 4 is a protein that in humans is encoded by the MAGEA4 gene.[1][2]

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this gene.[2]

References

  1. ↑ Rogner UC, Wilke K, Steck E, Korn B, Poustka A (Mar 1996). "The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28". Genomics. 29 (3): 725–31. doi:10.1006/geno.1995.9945. PMID 8575766.
  2. ↑ 2.0 2.1 "Entrez Gene: MAGEA4 melanoma antigen family A, 4".

Further reading



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