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{{ | '''Proto-oncogene DBL''' is a [[protein]] that in humans is encoded by the ''MCF2'' [[gene]].<ref name="pmid2577874">{{cite journal |vauthors=Noguchi T, Galland F, Batoz M, Mattei MG, Birnbaum D | title = Activation of a mcf.2 oncogene by deletion of amino-terminal coding sequences | journal = Oncogene | volume = 3 | issue = 6 | pages = 709–15 |date=Apr 1994 | pmid = 2577874 | pmc = | doi = }}</ref><ref name="pmid1611909">{{cite journal |vauthors=Galland F, Stefanova M, Lafage M, Birnbaum D | title = Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23 | journal = Cytogenet Cell Genet | volume = 60 | issue = 2 | pages = 114–6 |date=Jul 1992 | pmid = 1611909 | pmc = | doi =10.1159/000133316 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MCF2 MCF.2 cell line derived transforming sequence| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4168| accessdate = }}</ref> | ||
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| summary_text = MCF2 is a member of a large family of GDP-GTP exchange factors that modulate the activity of small GTPases of the Rho family. Five-prime recombinations result in the loss of N-terminal codons, producing MCF2 variants with oncogenic potential.[supplied by OMIM]<ref name="entrez" | | summary_text = MCF2 is a member of a large family of GDP-GTP exchange factors that modulate the activity of small GTPases of the Rho family. Five-prime recombinations result in the loss of N-terminal codons, producing MCF2 variants with oncogenic potential.[supplied by OMIM]<ref name="entrez" /> | ||
}} | }} | ||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
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| citations = | | citations = | ||
*{{cite journal | author= | *{{cite journal | author=Ron D |title=A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr |journal=New Biol. |volume=3 |issue= 4 |pages= 372–9 |year= 1991 |pmid= 2065022 |doi= |name-list-format=vanc| author2=Zannini M | author3=Lewis M | display-authors=3 | last4=Wickner | first4=RB | last5=Hunt | first5=LT | last6=Graziani | first6=G | last7=Tronick | first7=SR | last8=Aaronson | first8=SA | last9=Eva | first9=A }} | ||
*{{cite journal |vauthors=Tronick SR, McBride OW, Popescu NC, Eva A |title=Chromosomal localization of DBL oncogene sequences |journal=Genomics |volume=5 |issue= 3 |pages= 546–53 |year= 1990 |pmid= 2613238 |doi=10.1016/0888-7543(89)90022-0 }} | |||
*{{cite journal | | *{{cite journal | author=Ron D, Tronick SR, [[Stuart A. Aaronson|Aaronson SA]], Eva A |title=Molecular cloning and characterization of the human dbl proto-oncogene: evidence that its overexpression is sufficient to transform NIH/3T3 cells |journal=EMBO J. |volume=7 |issue= 8 |pages= 2465–73 |year= 1989 |pmid= 3056717 |doi= | pmc=457116 }} | ||
*{{cite journal | author=Tronick SR, | *{{cite journal | author=Eva A |title=The predicted DBL oncogene product defines a distinct class of transforming proteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 7 |pages= 2061–5 |year= 1988 |pmid= 3281159 |doi=10.1073/pnas.85.7.2061 | pmc=279928 |name-list-format=vanc| author2=Vecchio G | author3=Rao CD | display-authors=3 | last4=Tronick | first4=SR | last5=Aaronson | first5=SA }} | ||
*{{cite journal | author= | *{{cite journal |vauthors=Srivastava SK, Wheelock RH, Aaronson SA, Eva A |title=Identification of the protein encoded by the human diffuse B-cell lymphoma (dbl) oncogene |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 23 |pages= 8868–72 |year= 1987 |pmid= 3491366 |doi=10.1073/pnas.83.23.8868 | pmc=387034 }} | ||
*{{cite journal | author=Hart MJ |title=Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product |journal=J. Biol. Chem. |volume=269 |issue= 1 |pages= 62–5 |year= 1994 |pmid= 8276860 |doi= |name-list-format=vanc| author2=Eva A | author3=Zangrilli D | display-authors=3 | last4=Aaronson | first4=SA | last5=Evans | first5=T | last6=Cerione | first6=RA | last7=Zheng | first7=Y }} | |||
*{{cite journal |vauthors=Nishida K, Kaziro Y, Satoh T |title=Association of the proto-oncogene product dbl with G protein betagamma subunits |journal=FEBS Lett. |volume=459 |issue= 2 |pages= 186–90 |year= 1999 |pmid= 10518015 |doi=10.1016/S0014-5793(99)01244-2 }} | |||
*{{cite journal | author=Hart MJ | *{{cite journal |vauthors=Kato J, Kaziro Y, Satoh T |title=Activation of the guanine nucleotide exchange factor Dbl following ACK1-dependent tyrosine phosphorylation |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue= 1 |pages= 141–7 |year= 2000 |pmid= 10652228 |doi= 10.1006/bbrc.2000.2106 }} | ||
*{{cite journal |vauthors=Zhu K, Debreceni B, Li R, Zheng Y |title=Identification of Rho GTPase-dependent sites in the Dbl homology domain of oncogenic Dbl that are required for transformation |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 25993–6001 |year= 2000 |pmid= 10854437 |doi= 10.1074/jbc.M003780200 }} | |||
*{{cite journal | | *{{cite journal | author=Palmieri G |title=Human dbl proto-oncogene in 85 kb of xq26, and determination of the transcription initiation site |journal=Gene |volume=253 |issue= 1 |pages= 107–15 |year= 2000 |pmid= 10925207 |doi=10.1016/S0378-1119(00)00212-2 |name-list-format=vanc| author2=de Franciscis V | author3=Casamassimi A | display-authors=3 | last4=Romano | first4=G | last5=Torino | first5=A | last6=Pingitore | first6=P | last7=Califano | first7=D | last8=Santelli | first8=G | last9=Eva | first9=A }} | ||
*{{cite journal | | *{{cite journal |vauthors=Jin S, Exton JH |title=Activation of RhoA by association of Galpha(13) with Dbl |journal=Biochem. Biophys. Res. Commun. |volume=277 |issue= 3 |pages= 718–21 |year= 2000 |pmid= 11062019 |doi= 10.1006/bbrc.2000.3744 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Zhu K, Debreceni B, Bi F, Zheng Y |title=Oligomerization of DH domain is essential for Dbl-induced transformation |journal=Mol. Cell. Biol. |volume=21 |issue= 2 |pages= 425–37 |year= 2001 |pmid= 11134331 |doi= 10.1128/MCB.21.2.425-437.2001 | pmc=86589 }} | ||
*{{cite journal | author= | *{{cite journal | author=Vanni C |title=Regulation of proto-Dbl by intracellular membrane targeting and protein stability |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19745–53 |year= 2002 |pmid= 11907027 |doi= 10.1074/jbc.M111025200 |name-list-format=vanc| author2=Mancini P | author3=Gao Y | display-authors=3 | last4=Ottaviano | first4=C | last5=Guo | first5=F | last6=Salani | first6=B | last7=Torrisi | first7=MR | last8=Zheng | first8=Y | last9=Eva | first9=A }} | ||
*{{cite journal | author=Wennerberg K |title=RhoG signals in parallel with Rac1 and Cdc42 |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47810–7 |year= 2003 |pmid= 12376551 |doi= 10.1074/jbc.M203816200 |name-list-format=vanc| author2=Ellerbroek SM | author3=Liu RY | display-authors=3 | last4=Karnoub | first4=AE | last5=Burridge | first5=K | last6=Der | first6=CJ }} | |||
*{{cite journal | author=Komai K |title=Alternative splicing variants of the human DBL (MCF-2) proto-oncogene |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 3 |pages= 455–8 |year= 2003 |pmid= 12445822 |doi=10.1016/S0006-291X(02)02645-1 |name-list-format=vanc| author2=Okayama R | author3=Kitagawa M | display-authors=3 | last4=Yagi | first4=H | last5=Chihara | first5=K | last6=Shiozawa | first6=S }} | |||
*{{cite journal | | *{{cite journal |vauthors=Komai K, Mukae-Sakairi N, Kitagawa M, Shiozawa S |title=Characterization of novel splicing variants of the mouse MCF-2 (DBL) proto-oncogene |journal=Biochem. Biophys. Res. Commun. |volume=309 |issue= 4 |pages= 906–9 |year= 2003 |pmid= 13679059 |doi=10.1016/j.bbrc.2003.08.088 }} | ||
*{{cite journal | author= | *{{cite journal | author=Ross MT |title=The DNA sequence of the human X chromosome |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 | pmc=2665286 |name-list-format=vanc| author2=Grafham DV | author3=Coffey AJ | display-authors=3 | last4=Scherer | first4=Steven | last5=McLay | first5=Kirsten | last6=Muzny | first6=Donna | last7=Platzer | first7=Matthias | last8=Howell | first8=Gareth R. | last9=Burrows | first9=Christine }} | ||
*{{cite journal | author=Kimura K |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |name-list-format=vanc| author2=Wakamatsu A | author3=Suzuki Y | display-authors=3 | last4=Ota | first4=T | last5=Nishikawa | first5=T | last6=Yamashita | first6=R | last7=Yamamoto | first7=J | last8=Sekine | first8=M | last9=Tsuritani | first9=K }} | |||
*{{cite journal | author= | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
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{{gene-X-stub}} |
Revision as of 06:14, 4 September 2017
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Species | Human | Mouse | |||||
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Location (UCSC) | n/a | n/a | |||||
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Proto-oncogene DBL is a protein that in humans is encoded by the MCF2 gene.[1][2][3]
MCF2 is a member of a large family of GDP-GTP exchange factors that modulate the activity of small GTPases of the Rho family. Five-prime recombinations result in the loss of N-terminal codons, producing MCF2 variants with oncogenic potential.[supplied by OMIM][3]
References
- ↑ Noguchi T, Galland F, Batoz M, Mattei MG, Birnbaum D (Apr 1994). "Activation of a mcf.2 oncogene by deletion of amino-terminal coding sequences". Oncogene. 3 (6): 709–15. PMID 2577874.
- ↑ Galland F, Stefanova M, Lafage M, Birnbaum D (Jul 1992). "Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23". Cytogenet Cell Genet. 60 (2): 114–6. doi:10.1159/000133316. PMID 1611909.
- ↑ 3.0 3.1 "Entrez Gene: MCF2 MCF.2 cell line derived transforming sequence".
Further reading
- Ron D, Zannini M, Lewis M, et al. (1991). "A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr". New Biol. 3 (4): 372–9. PMID 2065022.
- Tronick SR, McBride OW, Popescu NC, Eva A (1990). "Chromosomal localization of DBL oncogene sequences". Genomics. 5 (3): 546–53. doi:10.1016/0888-7543(89)90022-0. PMID 2613238.
- Ron D, Tronick SR, Aaronson SA, Eva A (1989). "Molecular cloning and characterization of the human dbl proto-oncogene: evidence that its overexpression is sufficient to transform NIH/3T3 cells". EMBO J. 7 (8): 2465–73. PMC 457116. PMID 3056717.
- Eva A, Vecchio G, Rao CD, et al. (1988). "The predicted DBL oncogene product defines a distinct class of transforming proteins". Proc. Natl. Acad. Sci. U.S.A. 85 (7): 2061–5. doi:10.1073/pnas.85.7.2061. PMC 279928. PMID 3281159.
- Srivastava SK, Wheelock RH, Aaronson SA, Eva A (1987). "Identification of the protein encoded by the human diffuse B-cell lymphoma (dbl) oncogene". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 8868–72. doi:10.1073/pnas.83.23.8868. PMC 387034. PMID 3491366.
- Hart MJ, Eva A, Zangrilli D, et al. (1994). "Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product". J. Biol. Chem. 269 (1): 62–5. PMID 8276860.
- Nishida K, Kaziro Y, Satoh T (1999). "Association of the proto-oncogene product dbl with G protein betagamma subunits". FEBS Lett. 459 (2): 186–90. doi:10.1016/S0014-5793(99)01244-2. PMID 10518015.
- Kato J, Kaziro Y, Satoh T (2000). "Activation of the guanine nucleotide exchange factor Dbl following ACK1-dependent tyrosine phosphorylation". Biochem. Biophys. Res. Commun. 268 (1): 141–7. doi:10.1006/bbrc.2000.2106. PMID 10652228.
- Zhu K, Debreceni B, Li R, Zheng Y (2000). "Identification of Rho GTPase-dependent sites in the Dbl homology domain of oncogenic Dbl that are required for transformation". J. Biol. Chem. 275 (34): 25993–6001. doi:10.1074/jbc.M003780200. PMID 10854437.
- Palmieri G, de Franciscis V, Casamassimi A, et al. (2000). "Human dbl proto-oncogene in 85 kb of xq26, and determination of the transcription initiation site". Gene. 253 (1): 107–15. doi:10.1016/S0378-1119(00)00212-2. PMID 10925207.
- Jin S, Exton JH (2000). "Activation of RhoA by association of Galpha(13) with Dbl". Biochem. Biophys. Res. Commun. 277 (3): 718–21. doi:10.1006/bbrc.2000.3744. PMID 11062019.
- Zhu K, Debreceni B, Bi F, Zheng Y (2001). "Oligomerization of DH domain is essential for Dbl-induced transformation". Mol. Cell. Biol. 21 (2): 425–37. doi:10.1128/MCB.21.2.425-437.2001. PMC 86589. PMID 11134331.
- Vanni C, Mancini P, Gao Y, et al. (2002). "Regulation of proto-Dbl by intracellular membrane targeting and protein stability". J. Biol. Chem. 277 (22): 19745–53. doi:10.1074/jbc.M111025200. PMID 11907027.
- Wennerberg K, Ellerbroek SM, Liu RY, et al. (2003). "RhoG signals in parallel with Rac1 and Cdc42". J. Biol. Chem. 277 (49): 47810–7. doi:10.1074/jbc.M203816200. PMID 12376551.
- Komai K, Okayama R, Kitagawa M, et al. (2003). "Alternative splicing variants of the human DBL (MCF-2) proto-oncogene". Biochem. Biophys. Res. Commun. 299 (3): 455–8. doi:10.1016/S0006-291X(02)02645-1. PMID 12445822.
- Komai K, Mukae-Sakairi N, Kitagawa M, Shiozawa S (2003). "Characterization of novel splicing variants of the mouse MCF-2 (DBL) proto-oncogene". Biochem. Biophys. Res. Commun. 309 (4): 906–9. doi:10.1016/j.bbrc.2003.08.088. PMID 13679059.
- Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
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