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{{Infobox_gene}}
{{PBB_Controls
'''Serine/threonine-protein phosphatase with EF-hands 1''' is an [[enzyme]] that in humans is encoded by the ''PPEF1'' [[gene]].<ref name="pmid9215685">{{cite journal | vauthors = Montini E, Rugarli EI, Van de Vosse E, Andolfi G, Mariani M, Puca AA, Consalez GG, den Dunnen JT, Ballabio A, Franco B | title = A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin | journal = Human Molecular Genetics | volume = 6 | issue = 7 | pages = 1137–45 | date = Jul 1997 | pmid = 9215685 | pmc =  | doi = 10.1093/hmg/6.7.1137 }}</ref><ref name="pmid9326663">{{cite journal | vauthors = Sherman PM, Sun H, Macke JP, Williams J, Smallwood PM, Nathans J | title = Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 21 | pages = 11639–44 | date = Oct 1997 | pmid = 9326663 | pmc = 23563 | doi = 10.1073/pnas.94.21.11639 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PPEF1 protein phosphatase, EF-hand calcium binding domain 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5475| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Protein phosphatase, EF-hand calcium binding domain 1
| HGNCid = 9243
| Symbol = PPEF1
| AltSymbols =; PP7; PPEF; PPP7C
| OMIM = 300109
| ECnumber = 
| Homologene = 55960
| MGIid = 1097157
| GeneAtlas_image1 = PBB_GE_PPEF1_206547_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004722 |text = protein serine/threonine phosphatase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0030145 |text = manganese ion binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006470 |text = protein amino acid dephosphorylation}} {{GNF_GO|id=GO:0050906 |text = detection of stimulus during sensory perception}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5475
    | Hs_Ensembl = ENSG00000086717
    | Hs_RefseqProtein = NP_006231
    | Hs_RefseqmRNA = NM_006240
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 18618765
    | Hs_GenLoc_end = 18756097
    | Hs_Uniprot = O14829
    | Mm_EntrezGene = 237178
    | Mm_Ensembl = ENSMUSG00000062168
    | Mm_RefseqmRNA = XM_142281
    | Mm_RefseqProtein = XP_142281
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 155985935
    | Mm_GenLoc_end = 156079634
    | Mm_Uniprot = O35655
  }}
}}
'''Protein phosphatase, EF-hand calcium binding domain 1''', also known as '''PPEF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PPEF1 protein phosphatase, EF-hand calcium binding domain 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5475| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described.<ref name="entrez">{{cite web | title = Entrez Gene: PPEF1 protein phosphatase, EF-hand calcium binding domain 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5475| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
PPEF1 has been shown to [[Protein-protein interaction|interact]] with [[Calmodulin 1]].<ref name=pmid12051765>{{cite journal | vauthors = Kutuzov MA, Solov'eva OV, Andreeva AV, Bennett N | title = Protein Ser/Thr phosphatases PPEF interact with calmodulin | journal = Biochemical and Biophysical Research Communications | volume = 293 | issue = 3 | pages = 1047–52 | date = May 2002 | pmid = 12051765 | doi = 10.1016/S0006-291X(02)00338-8 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Herzig S, Neumann J | title = Effects of serine/threonine protein phosphatases on ion channels in excitable membranes | journal = Physiological Reviews | volume = 80 | issue = 1 | pages = 173–210 | date = Jan 2000 | pmid = 10617768 | doi =  }}
| citations =
* {{cite journal | vauthors = Huang X, Honkanen RE | title = Molecular cloning, expression, and characterization of a novel human serine/threonine protein phosphatase, PP7, that is homologous to Drosophila retinal degeneration C gene product (rdgC) | journal = The Journal of Biological Chemistry | volume = 273 | issue = 3 | pages = 1462–8 | date = Jan 1998 | pmid = 9430683 | doi = 10.1074/jbc.273.3.1462 }}
*{{cite journal | author=Herzig S, Neumann J |title=Effects of serine/threonine protein phosphatases on ion channels in excitable membranes. |journal=Physiol. Rev. |volume=80 |issue= 1 |pages= 173-210 |year= 2000 |pmid= 10617768 |doi=  }}
* {{cite journal | vauthors = Ramulu P, Kennedy M, Xiong WH, Williams J, Cowan M, Blesh D, Yau KW, Hurley JB, Nathans J | title = Normal light response, photoreceptor integrity, and rhodopsin dephosphorylation in mice lacking both protein phosphatases with EF hands (PPEF-1 and PPEF-2) | journal = Molecular and Cellular Biology | volume = 21 | issue = 24 | pages = 8605–14 | date = Dec 2001 | pmid = 11713293 | pmc = 100021 | doi = 10.1128/MCB.21.24.8605-8614.2001 }}
*{{cite journal | author=Montini E, Rugarli EI, Van de Vosse E, ''et al.'' |title=A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin. |journal=Hum. Mol. Genet. |volume=6 |issue= 7 |pages= 1137-45 |year= 1997 |pmid= 9215685 |doi=  }}
* {{cite journal | vauthors = Kutuzov MA, Solov'eva OV, Andreeva AV, Bennett N | title = Protein Ser/Thr phosphatases PPEF interact with calmodulin | journal = Biochemical and Biophysical Research Communications | volume = 293 | issue = 3 | pages = 1047–52 | date = May 2002 | pmid = 12051765 | doi = 10.1016/S0006-291X(02)00338-8 }}
*{{cite journal  | author=Sherman PM, Sun H, Macke JP, ''et al.'' |title=Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 21 |pages= 11639-44 |year= 1997 |pmid= 9326663 |doi=  }}
* {{cite journal | vauthors = Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J | title = Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides | journal = Nature Biotechnology | volume = 21 | issue = 5 | pages = 566–9 | date = May 2003 | pmid = 12665801 | doi = 10.1038/nbt810 }}
*{{cite journal  | author=Huang X, Honkanen RE |title=Molecular cloning, expression, and characterization of a novel human serine/threonine protein phosphatase, PP7, that is homologous to Drosophila retinal degeneration C gene product (rdgC). |journal=J. Biol. Chem. |volume=273 |issue= 3 |pages= 1462-8 |year= 1998 |pmid= 9430683 |doi= }}
* {{cite journal | vauthors = Hillman RT, Green RE, Brenner SE | title = An unappreciated role for RNA surveillance | journal = Genome Biology | volume = 5 | issue = 2 | pages = R8 | year = 2005 | pmid = 14759258 | pmc = 395752 | doi = 10.1186/gb-2004-5-2-r8 }}
*{{cite journal | author=Ramulu P, Kennedy M, Xiong WH, ''et al.'' |title=Normal light response, photoreceptor integrity, and rhodopsin dephosphorylation in mice lacking both protein phosphatases with EF hands (PPEF-1 and PPEF-2). |journal=Mol. Cell. Biol. |volume=21 |issue= 24 |pages= 8605-14 |year= 2001 |pmid= 11713293 |doi= 10.1128/MCB.21.24.8605-8614.2001 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Kutuzov MA, Solov'eva OV, Andreeva AV, Bennett N |title=Protein Ser/Thr phosphatases PPEF interact with calmodulin. |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 3 |pages= 1047-52 |year= 2002 |pmid= 12051765 |doi= 10.1016/S0006-291X(02)00338-8 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal | author=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance. |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Ross MT, Grafham DV, Coffey AJ, ''et al.'' |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
{{refend}}
{{refend}}


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{{WikiDoc Sources}}
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[[Category:EF-hand-containing proteins]]

Revision as of 18:30, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serine/threonine-protein phosphatase with EF-hands 1 is an enzyme that in humans is encoded by the PPEF1 gene.[1][2][3]

Function

This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described.[3]

Interactions

PPEF1 has been shown to interact with Calmodulin 1.[4]

References

  1. ↑ Montini E, Rugarli EI, Van de Vosse E, Andolfi G, Mariani M, Puca AA, Consalez GG, den Dunnen JT, Ballabio A, Franco B (Jul 1997). "A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin". Human Molecular Genetics. 6 (7): 1137–45. doi:10.1093/hmg/6.7.1137. PMID 9215685.
  2. ↑ Sherman PM, Sun H, Macke JP, Williams J, Smallwood PM, Nathans J (Oct 1997). "Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C". Proceedings of the National Academy of Sciences of the United States of America. 94 (21): 11639–44. doi:10.1073/pnas.94.21.11639. PMC 23563. PMID 9326663.
  3. ↑ 3.0 3.1 "Entrez Gene: PPEF1 protein phosphatase, EF-hand calcium binding domain 1".
  4. ↑ Kutuzov MA, Solov'eva OV, Andreeva AV, Bennett N (May 2002). "Protein Ser/Thr phosphatases PPEF interact with calmodulin". Biochemical and Biophysical Research Communications. 293 (3): 1047–52. doi:10.1016/S0006-291X(02)00338-8. PMID 12051765.

Further reading


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