SMARCA1: Difference between revisions

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'''Probable global transcription activator SNF2L1''' is a [[protein]] that in humans is encoded by the ''SMARCA1'' [[gene]].<ref name="pmid1408766">{{cite journal | vauthors = Okabe I, Bailey LC, Attree O, Srinivasan S, Perkel JM, Laurent BC, Carlson M, Nelson DL, Nussbaum RL | title = Cloning of human and bovine homologs of SNF2/SWI2: a global activator of transcription in yeast S. cerevisiae | journal = Nucleic Acids Res | volume = 20 | issue = 17 | pages = 4649–55 |date=Oct 1992 | pmid = 1408766 | pmc = 334196 | doi =10.1093/nar/20.17.4649 }}</ref><ref name="pmid14609955">{{cite journal | vauthors = Barak O, Lazzaro MA, Lane WS, Speicher DW, Picketts DJ, Shiekhattar R | title = Isolation of human NURF: a regulator of Engrailed gene expression | journal = EMBO J | volume = 22 | issue = 22 | pages = 6089–100 |date=Nov 2003 | pmid = 14609955 | pmc = 275440 | doi = 10.1093/emboj/cdg582 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6594| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
| HGNCid = 11097
| Symbol = SMARCA1
| AltSymbols =; ISWI; NURF140; SNF2L; SNF2L1; SNF2LB; SWI; SWI2
| OMIM = 300012
| ECnumber =
| Homologene = 55711
| MGIid = 1935127
| GeneAtlas_image1 = PBB_GE_SMARCA1_203874_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SMARCA1_203875_at_tn.png
| GeneAtlas_image3 = PBB_GE_SMARCA1_215294_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0004386 |text = helicase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008094 |text = DNA-dependent ATPase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006338 |text = chromatin remodeling}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007420 |text = brain development}} {{GNF_GO|id=GO:0030182 |text = neuron differentiation}} {{GNF_GO|id=GO:0043193 |text = positive regulation of gene-specific transcription}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6594
    | Hs_Ensembl = ENSG00000102038
    | Hs_RefseqProtein = NP_003060
    | Hs_RefseqmRNA = NM_003069
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 128408163
    | Hs_GenLoc_end = 128485158
    | Hs_Uniprot = P28370
    | Mm_EntrezGene = 93761
    | Mm_Ensembl = ENSMUSG00000031099
    | Mm_RefseqmRNA = NM_053123
    | Mm_RefseqProtein = NP_444353
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 44053997
    | Mm_GenLoc_end = 44137179
    | Mm_Uniprot = Q05DE7
  }}
}}
'''SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1''', also known as '''SMARCA1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6594| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6594| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Okabe I, Bailey LC, Attree O, ''et al.'' |title=Cloning of human and bovine homologs of SNF2/SWI2: a global activator of transcription in yeast S. cerevisiae. |journal=Nucleic Acids Res. |volume=20 |issue= 17 |pages= 4649-55 |year= 1992 |pmid= 1408766 |doi=  }}
*{{cite journal  | vauthors=Bozhenok L, Wade PA, Varga-Weisz P |title=WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci. |journal=EMBO J. |volume=21 |issue= 9 |pages= 2231–41 |year= 2002 |pmid= 11980720 |doi= 10.1093/emboj/21.9.2231 | pmc=125993 }}
*{{cite journal  | author=Bozhenok L, Wade PA, Varga-Weisz P |title=WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci. |journal=EMBO J. |volume=21 |issue= 9 |pages= 2231-41 |year= 2002 |pmid= 11980720 |doi= 10.1093/emboj/21.9.2231 }}
*{{cite journal   |vauthors=Maguire PB, Wynne KJ, Harney DF, etal |title=Identification of the phosphotyrosine proteome from thrombin activated platelets. |journal=Proteomics |volume=2 |issue= 6 |pages= 642–8 |year= 2003 |pmid= 12112843 |doi= 10.1002/1615-9861(200206)2:6<642::AID-PROT642>3.0.CO;2-I }}
*{{cite journal | author=Maguire PB, Wynne KJ, Harney DF, ''et al.'' |title=Identification of the phosphotyrosine proteome from thrombin activated platelets. |journal=Proteomics |volume=2 |issue= 6 |pages= 642-8 |year= 2003 |pmid= 12112843 |doi= 10.1002/1615-9861(200206)2:6&lt;642::AID-PROT642&gt;3.0.CO;2-I }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Barak O, Lazzaro MA, Lane WS, ''et al.'' |title=Isolation of human NURF: a regulator of Engrailed gene expression. |journal=EMBO J. |volume=22 |issue= 22 |pages= 6089-100 |year= 2004 |pmid= 14609955 |doi= 10.1093/emboj/cdg582 }}
*{{cite journal   |vauthors=Barak O, Lazzaro MA, Cooch NS, etal |title=A tissue-specific, naturally occurring human SNF2L variant inactivates chromatin remodeling. |journal=J. Biol. Chem. |volume=279 |issue= 43 |pages= 45130–8 |year= 2004 |pmid= 15310751 |doi= 10.1074/jbc.M406212200 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Wang F, Zhang R, Beischlag TV, etal |title=Roles of Brahma and Brahma/SWI2-related gene 1 in hypoxic induction of the erythropoietin gene. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 46733–41 |year= 2004 |pmid= 15347669 |doi= 10.1074/jbc.M409002200 }}
*{{cite journal | author=Barak O, Lazzaro MA, Cooch NS, ''et al.'' |title=A tissue-specific, naturally occurring human SNF2L variant inactivates chromatin remodeling. |journal=J. Biol. Chem. |volume=279 |issue= 43 |pages= 45130-8 |year= 2004 |pmid= 15310751 |doi= 10.1074/jbc.M406212200 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Wang F, Zhang R, Beischlag TV, ''et al.'' |title=Roles of Brahma and Brahma/SWI2-related gene 1 in hypoxic induction of the erythropoietin gene. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 46733-41 |year= 2004 |pmid= 15347669 |doi= 10.1074/jbc.M409002200 }}
*{{cite journal   |vauthors=Banting GS, Barak O, Ames TM, etal |title=CECR2, a protein involved in neurulation, forms a novel chromatin remodeling complex with SNF2L. |journal=Hum. Mol. Genet. |volume=14 |issue= 4 |pages= 513–24 |year= 2005 |pmid= 15640247 |doi= 10.1093/hmg/ddi048 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Ross MT, Grafham DV, Coffey AJ, etal |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 | pmc=2665286 }}
*{{cite journal | author=Banting GS, Barak O, Ames TM, ''et al.'' |title=CECR2, a protein involved in neurulation, forms a novel chromatin remodeling complex with SNF2L. |journal=Hum. Mol. Genet. |volume=14 |issue= 4 |pages= 513-24 |year= 2005 |pmid= 15640247 |doi= 10.1093/hmg/ddi048 }}
*{{cite journal   |vauthors=Lazzaro MA, Pépin D, Pescador N, etal |title=The imitation switch protein SNF2L regulates steroidogenic acute regulatory protein expression during terminal differentiation of ovarian granulosa cells. |journal=Mol. Endocrinol. |volume=20 |issue= 10 |pages= 2406–17 |year= 2006 |pmid= 16740656 |doi= 10.1210/me.2005-0213 }}
*{{cite journal | author=Ross MT, Grafham DV, Coffey AJ, ''et al.'' |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 }}
*{{cite journal | author=Lazzaro MA, Pépin D, Pescador N, ''et al.'' |title=The imitation switch protein SNF2L regulates steroidogenic acute regulatory protein expression during terminal differentiation of ovarian granulosa cells. |journal=Mol. Endocrinol. |volume=20 |issue= 10 |pages= 2406-17 |year= 2006 |pmid= 16740656 |doi= 10.1210/me.2005-0213 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 06:39, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Probable global transcription activator SNF2L1 is a protein that in humans is encoded by the SMARCA1 gene.[1][2][3]

The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. Two transcript variants encoding different isoforms have been found for this gene.[3]

References

  1. ↑ Okabe I, Bailey LC, Attree O, Srinivasan S, Perkel JM, Laurent BC, Carlson M, Nelson DL, Nussbaum RL (Oct 1992). "Cloning of human and bovine homologs of SNF2/SWI2: a global activator of transcription in yeast S. cerevisiae". Nucleic Acids Res. 20 (17): 4649–55. doi:10.1093/nar/20.17.4649. PMC 334196. PMID 1408766.
  2. ↑ Barak O, Lazzaro MA, Lane WS, Speicher DW, Picketts DJ, Shiekhattar R (Nov 2003). "Isolation of human NURF: a regulator of Engrailed gene expression". EMBO J. 22 (22): 6089–100. doi:10.1093/emboj/cdg582. PMC 275440. PMID 14609955.
  3. ↑ 3.0 3.1 "Entrez Gene: SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1".

Further reading



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