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{{Infobox_gene}}
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'''Melanoma-associated antigen 2''' is a [[protein]] that in humans is encoded by the ''MAGEA2'' [[gene]].<ref name="pmid1840703">{{cite journal |vauthors=van der Bruggen P, Traversari C, Chomez P, Lurquin C, De Plaen E, Van den Eynde B, Knuth A, Boon T | title = A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma | journal = Science | volume = 254 | issue = 5038 | pages = 1643–7 |date=Jan 1992 | pmid = 1840703 | pmc =  | doi =10.1126/science.1840703 }}</ref><ref name="pmid8575766">{{cite journal |vauthors=Rogner UC, Wilke K, Steck E, Korn B, Poustka A | title = The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28 | journal = Genomics | volume = 29 | issue = 3 | pages = 725–31 |date=Mar 1996 | pmid = 8575766 | pmc =  | doi = 10.1006/geno.1995.9945 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAGEA2 melanoma antigen family A, 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4101| accessdate = }}</ref>
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| image =
| image_source = 
| PDB =
| Name = Melanoma antigen family A, 2
| HGNCid = 6800
| Symbol = MAGEA2
| AltSymbols =; MAGE2; MAGEA2A; MGC131923; MAGEA2; MGC16973
| OMIM = 300173
| ECnumber =
| Homologene = 18781
| MGIid =
| Function =  
  | Component =  
  | Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4101
    | Hs_Ensembl =
    | Hs_RefseqProtein = NP_005352
    | Hs_RefseqmRNA = NM_005361
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start =
    | Hs_GenLoc_end =
    | Hs_Uniprot =
    | Mm_EntrezGene =
    | Mm_Ensembl =   
    | Mm_RefseqmRNA =
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
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'''Melanoma antigen family A, 2''', also known as '''MAGEA2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAGEA2 melanoma antigen family A, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4101| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: MAGEA2 melanoma antigen family A, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4101| accessdate = }}</ref>
| summary_text = This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=van der Bruggen P, Traversari C, Chomez P, ''et al.'' |title=A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. |journal=Science |volume=254 |issue= 5038 |pages= 1643-7 |year= 1992 |pmid= 1840703 |doi=  }}
*{{cite journal   |vauthors=Brasseur F, Rimoldi D, Liénard D, etal |title=Expression of MAGE genes in primary and metastatic cutaneous melanoma. |journal=Int. J. Cancer |volume=63 |issue= 3 |pages= 375–80 |year= 1995 |pmid= 7591235 |doi=10.1002/ijc.2910630313 }}
*{{cite journal  | author=Brasseur F, Rimoldi D, Liénard D, ''et al.'' |title=Expression of MAGE genes in primary and metastatic cutaneous melanoma. |journal=Int. J. Cancer |volume=63 |issue= 3 |pages= 375-80 |year= 1995 |pmid= 7591235 |doi=  }}
*{{cite journal   |vauthors=De Plaen E, Arden K, Traversari C, etal |title=Structure, chromosomal localization, and expression of 12 genes of the MAGE family. |journal=Immunogenetics |volume=40 |issue= 5 |pages= 360–9 |year= 1994 |pmid= 7927540 |doi=10.1007/BF01246677 }}
*{{cite journal | author=De Plaen E, Arden K, Traversari C, ''et al.'' |title=Structure, chromosomal localization, and expression of 12 genes of the MAGE family. |journal=Immunogenetics |volume=40 |issue= 5 |pages= 360-9 |year= 1994 |pmid= 7927540 |doi=  }}
*{{cite journal   |vauthors=Gaugler B, Van den Eynde B, van der Bruggen P, etal |title=Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes. |journal=J. Exp. Med. |volume=179 |issue= 3 |pages= 921–30 |year= 1994 |pmid= 8113684 |doi=10.1084/jem.179.3.921  | pmc=2191409 }}
*{{cite journal | author=Gaugler B, Van den Eynde B, van der Bruggen P, ''et al.'' |title=Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes. |journal=J. Exp. Med. |volume=179 |issue= 3 |pages= 921-30 |year= 1994 |pmid= 8113684 |doi=  }}
*{{cite journal   |vauthors=De Smet C, Lurquin C, van der Bruggen P, etal |title=Sequence and expression pattern of the human MAGE2 gene. |journal=Immunogenetics |volume=39 |issue= 2 |pages= 121–9 |year= 1994 |pmid= 8276455 |doi=  10.1007/bf00188615}}
*{{cite journal | author=De Smet C, Lurquin C, van der Bruggen P, ''et al.'' |title=Sequence and expression pattern of the human MAGE2 gene. |journal=Immunogenetics |volume=39 |issue= 2 |pages= 121-9 |year= 1994 |pmid= 8276455 |doi=  }}
*{{cite journal   |vauthors=Zakut R, Topalian SL, Kawakami Y, etal |title=Differential expression of MAGE-1, -2, and -3 messenger RNA in transformed and normal human cell lines. |journal=Cancer Res. |volume=53 |issue= 1 |pages= 5–8 |year= 1993 |pmid= 8416750 |doi=  }}
*{{cite journal | author=Zakut R, Topalian SL, Kawakami Y, ''et al.'' |title=Differential expression of MAGE-1, -2, and -3 messenger RNA in transformed and normal human cell lines. |journal=Cancer Res. |volume=53 |issue= 1 |pages= 5-8 |year= 1993 |pmid= 8416750 |doi=  }}
*{{cite journal   |vauthors=Mallon AM, Platzer M, Bate R, etal |title=Comparative genome sequence analysis of the Bpa/Str region in mouse and Man. |journal=Genome Res. |volume=10 |issue= 6 |pages= 758–75 |year= 2000 |pmid= 10854409 |doi=10.1101/gr.10.6.758  | pmc=310879 }}
*{{cite journal | author=Rogner UC, Wilke K, Steck E, ''et al.'' |title=The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. |journal=Genomics |volume=29 |issue= 3 |pages= 725-31 |year= 1996 |pmid= 8575766 |doi= 10.1006/geno.1995.9945 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Mallon AM, Platzer M, Bate R, ''et al.'' |title=Comparative genome sequence analysis of the Bpa/Str region in mouse and Man. |journal=Genome Res. |volume=10 |issue= 6 |pages= 758-75 |year= 2000 |pmid= 10854409 |doi=  }}
*{{cite journal   |vauthors=Nagao T, Higashitsuji H, Nonoguchi K, etal |title=MAGE-A4 interacts with the liver oncoprotein gankyrin and suppresses its tumorigenic activity. |journal=J. Biol. Chem. |volume=278 |issue= 12 |pages= 10668–74 |year= 2003 |pmid= 12525503 |doi= 10.1074/jbc.M206104200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Nagao T, Higashitsuji H, Nonoguchi K, ''et al.'' |title=MAGE-A4 interacts with the liver oncoprotein gankyrin and suppresses its tumorigenic activity. |journal=J. Biol. Chem. |volume=278 |issue= 12 |pages= 10668-74 |year= 2003 |pmid= 12525503 |doi= 10.1074/jbc.M206104200 }}
*{{cite journal   |vauthors=Monte M, Simonatto M, Peche LY, etal |title=MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 30 |pages= 11160–5 |year= 2006 |pmid= 16847267 |doi= 10.1073/pnas.0510834103 | pmc=1544058 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Wischnewski F, Friese O, Pantel K, Schwarzenbach H |title=Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters. |journal=Mol. Cancer Res. |volume=5 |issue= 7 |pages= 749–59 |year= 2007 |pmid= 17634428 |doi= 10.1158/1541-7786.MCR-06-0364 }}
*{{cite journal | author=Monte M, Simonatto M, Peche LY, ''et al.'' |title=MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 30 |pages= 11160-5 |year= 2006 |pmid= 16847267 |doi= 10.1073/pnas.0510834103 }}
*{{cite journal  | author=Wischnewski F, Friese O, Pantel K, Schwarzenbach H |title=Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters. |journal=Mol. Cancer Res. |volume=5 |issue= 7 |pages= 749-59 |year= 2007 |pmid= 17634428 |doi= 10.1158/1541-7786.MCR-06-0364 }}
}}
}}
{{refend}}
{{refend}}
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Latest revision as of 06:01, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Melanoma-associated antigen 2 is a protein that in humans is encoded by the MAGEA2 gene.[1][2][3]

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.[3]

References

  1. ↑ van der Bruggen P, Traversari C, Chomez P, Lurquin C, De Plaen E, Van den Eynde B, Knuth A, Boon T (Jan 1992). "A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma". Science. 254 (5038): 1643–7. doi:10.1126/science.1840703. PMID 1840703.
  2. ↑ Rogner UC, Wilke K, Steck E, Korn B, Poustka A (Mar 1996). "The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28". Genomics. 29 (3): 725–31. doi:10.1006/geno.1995.9945. PMID 8575766.
  3. ↑ 3.0 3.1 "Entrez Gene: MAGEA2 melanoma antigen family A, 2".

Further reading



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