HNRPH2: Difference between revisions

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{{Infobox_gene}}
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'''Heterogeneous nuclear ribonucleoprotein H2''' is a [[protein]] that in humans is encoded by the ''HNRNPH2'' [[gene]].<ref name="pmid7499401">{{cite journal |vauthors=Honore B, Rasmussen HH, Vorum H, Dejgaard K, Liu X, Gromov P, Madsen P, Gesser B, Tommerup N, Celis JE | title = Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes | journal = J Biol Chem | volume = 270 | issue = 48 | pages = 28780–9 |date=Jan 1996 | pmid = 7499401 | pmc =  | doi =10.1074/jbc.270.48.28780 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HNRPH2 heterogeneous nuclear ribonucleoprotein H2 (H')| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3188| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_HNRPH2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wez.
| PDB = {{PDB2|1wez}}, {{PDB2|1wg5}}
| Name = Heterogeneous nuclear ribonucleoprotein H2 (H')
| HGNCid = 5042
| Symbol = HNRPH2
| AltSymbols =; FTP3; HNRPH'; hnRNPH'
| OMIM = 601036
| ECnumber =
| Homologene = 23165
| MGIid = 1201779
  | GeneAtlas_image1 = PBB_GE_HNRPH2_201132_at_tn.png
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0030530 |text = heterogeneous nuclear ribonucleoprotein complex}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3188
    | Hs_Ensembl = ENSG00000126945
    | Hs_RefseqProtein = NP_001027565
    | Hs_RefseqmRNA = NM_001032393
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 100549847
    | Hs_GenLoc_end = 100555762
    | Hs_Uniprot = P55795
    | Mm_EntrezGene = 56258
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_019868
    | Mm_RefseqProtein = NP_063921
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Heterogeneous nuclear ribonucleoprotein H2 (H')''', also known as '''HNRPH2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HNRPH2 heterogeneous nuclear ribonucleoprotein H2 (H')| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3188| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member HNRPH1. This gene is thought to be involved in Fabray disease and X-linked agammaglobulinemia phenotype. Alternative splicing results in multiple transcript variants encoding the same protein.<ref name="entrez">{{cite web | title = Entrez Gene: HNRPH2 heterogeneous nuclear ribonucleoprotein H2 (H')| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3188| accessdate = }}</ref>
| summary_text = This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member HNRPH1. This gene is thought to be involved in [[Fabry disease]] and X-linked agammaglobulinemia phenotype. Alternative splicing results in multiple transcript variants encoding the same protein.<ref name="entrez">{{cite web | title = Entrez Gene: HNRPH2 heterogeneous nuclear ribonucleoprotein H2 (H')| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3188| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Honoré B, Rasmussen HH, Vorum H, ''et al.'' |title=Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes. |journal=J. Biol. Chem. |volume=270 |issue= 48 |pages= 28780-9 |year= 1996 |pmid= 7499401 |doi=  }}
*{{cite journal   |vauthors=Vorechovský I, Vetrie D, Holland J, etal |title=Isolation of cosmid and cDNA clones in the region surrounding the BTK gene at Xq21.3-q22. |journal=Genomics |volume=21 |issue= 3 |pages= 517–24 |year= 1994 |pmid= 7959728 |doi=10.1006/geno.1994.1310 }}
*{{cite journal  | author=Vorechovský I, Vetrie D, Holland J, ''et al.'' |title=Isolation of cosmid and cDNA clones in the region surrounding the BTK gene at Xq21.3-q22. |journal=Genomics |volume=21 |issue= 3 |pages= 517-24 |year= 1994 |pmid= 7959728 |doi=  }}
*{{cite journal   |vauthors=Vetrie D, Vorechovský I, Sideras P, etal |title=The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases. |journal=Nature |volume=361 |issue= 6409 |pages= 226–33 |year= 1993 |pmid= 8380905 |doi= 10.1038/361226a0 }}
*{{cite journal | author=Vetrie D, Vorechovský I, Sideras P, ''et al.'' |title=The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases. |journal=Nature |volume=361 |issue= 6409 |pages= 226-33 |year= 1993 |pmid= 8380905 |doi= 10.1038/361226a0 }}
*{{cite journal   |vauthors=Tsukada S, Saffran DC, Rawlings DJ, etal |title=Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. |journal=Cell |volume=72 |issue= 2 |pages= 279–90 |year= 1993 |pmid= 8425221 |doi=10.1016/0092-8674(93)90667-F }}
*{{cite journal | author=Tsukada S, Saffran DC, Rawlings DJ, ''et al.'' |title=Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. |journal=Cell |volume=72 |issue= 2 |pages= 279-90 |year= 1993 |pmid= 8425221 |doi=  }}
*{{cite journal   |vauthors=Oeltjen JC, Malley TM, Muzny DM, etal |title=Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains. |journal=Genome Res. |volume=7 |issue= 4 |pages= 315–29 |year= 1997 |pmid= 9110171 |doi=  10.1101/gr.7.4.315}}
*{{cite journal | author=Oeltjen JC, Malley TM, Muzny DM, ''et al.'' |title=Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains. |journal=Genome Res. |volume=7 |issue= 4 |pages= 315-29 |year= 1997 |pmid= 9110171 |doi=  }}
*{{cite journal  |vauthors=Honoré B, Vorum H, Baandrup U |title=hnRNPs H, H' and F behave differently with respect to posttranslational cleavage and subcellular localization. |journal=FEBS Lett. |volume=456 |issue= 2 |pages= 274–80 |year= 1999 |pmid= 10456323 |doi=10.1016/S0014-5793(99)00911-4 }}
*{{cite journal  | author=Honoré B, Vorum H, Baandrup U |title=hnRNPs H, H' and F behave differently with respect to posttranslational cleavage and subcellular localization. |journal=FEBS Lett. |volume=456 |issue= 2 |pages= 274-80 |year= 1999 |pmid= 10456323 |doi=  }}
*{{cite journal   |vauthors=Zhang Y, Lindblom T, Chang A, etal |title=Evidence that dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for dim1 interactions with hnRNP F and Npw38/PQBP-1. |journal=Gene |volume=257 |issue= 1 |pages= 33–43 |year= 2001 |pmid= 11054566 |doi=10.1016/S0378-1119(00)00372-3 }}
*{{cite journal | author=Zhang Y, Lindblom T, Chang A, ''et al.'' |title=Evidence that dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for dim1 interactions with hnRNP F and Npw38/PQBP-1. |journal=Gene |volume=257 |issue= 1 |pages= 33-43 |year= 2001 |pmid= 11054566 |doi=  }}
*{{cite journal  |vauthors=Caputi M, Zahler AM |title=Determination of the RNA binding specificity of the heterogeneous nuclear ribonucleoprotein (hnRNP) H/H'/F/2H9 family. |journal=J. Biol. Chem. |volume=276 |issue= 47 |pages= 43850–9 |year= 2001 |pmid= 11571276 |doi= 10.1074/jbc.M102861200 }}
*{{cite journal  | author=Caputi M, Zahler AM |title=Determination of the RNA binding specificity of the heterogeneous nuclear ribonucleoprotein (hnRNP) H/H'/F/2H9 family. |journal=J. Biol. Chem. |volume=276 |issue= 47 |pages= 43850-9 |year= 2001 |pmid= 11571276 |doi= 10.1074/jbc.M102861200 }}
*{{cite journal   |vauthors=Shu H, Chen S, Bi Q, etal |title=Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line. |journal=Mol. Cell. Proteomics |volume=3 |issue= 3 |pages= 279–86 |year= 2004 |pmid= 14729942 |doi= 10.1074/mcp.D300003-MCP200 }}
*{{cite journal | author=Shu H, Chen S, Bi Q, ''et al.'' |title=Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line. |journal=Mol. Cell Proteomics |volume=3 |issue= 3 |pages= 279-86 |year= 2004 |pmid= 14729942 |doi= 10.1074/mcp.D300003-MCP200 }}
*{{cite journal   |vauthors=Bouwmeester T, Bauch A, Ruffner H, etal |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
*{{cite journal | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
*{{cite journal  |vauthors=Honoré B, Baandrup U, Vorum H |title=Heterogeneous nuclear ribonucleoproteins F and H/H' show differential expression in normal and selected cancer tissues. |journal=Exp. Cell Res. |volume=294 |issue= 1 |pages= 199–209 |year= 2004 |pmid= 14980514 |doi= 10.1016/j.yexcr.2003.11.011 }}
*{{cite journal  | author=Honoré B, Baandrup U, Vorum H |title=Heterogeneous nuclear ribonucleoproteins F and H/H' show differential expression in normal and selected cancer tissues. |journal=Exp. Cell Res. |volume=294 |issue= 1 |pages= 199-209 |year= 2004 |pmid= 14980514 |doi= 10.1016/j.yexcr.2003.11.011 }}
*{{cite journal   |vauthors=Ross MT, Grafham DV, Coffey AJ, etal |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 | pmc=2665286 }}
*{{cite journal | author=Ross MT, Grafham DV, Coffey AJ, ''et al.'' |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 }}
*{{cite journal  |vauthors=Alkan SA, Martincic K, Milcarek C |title=The hnRNPs F and H2 bind to similar sequences to influence gene expression. |journal=Biochem. J. |volume=393 |issue= Pt 1 |pages= 361–71 |year= 2006 |pmid= 16171461 |doi= 10.1042/BJ20050538 | pmc=1383695 }}
*{{cite journal  | author=Alkan SA, Martincic K, Milcarek C |title=The hnRNPs F and H2 bind to similar sequences to influence gene expression. |journal=Biochem. J. |volume=393 |issue= Pt 1 |pages= 361-71 |year= 2006 |pmid= 16171461 |doi= 10.1042/BJ20050538 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=3188}}
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Revision as of 13:58, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (protein)

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Wikidata
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Heterogeneous nuclear ribonucleoprotein H2 is a protein that in humans is encoded by the HNRNPH2 gene.[1][2]

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member HNRPH1. This gene is thought to be involved in Fabry disease and X-linked agammaglobulinemia phenotype. Alternative splicing results in multiple transcript variants encoding the same protein.[2]

References

  1. ↑ Honore B, Rasmussen HH, Vorum H, Dejgaard K, Liu X, Gromov P, Madsen P, Gesser B, Tommerup N, Celis JE (Jan 1996). "Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes". J Biol Chem. 270 (48): 28780–9. doi:10.1074/jbc.270.48.28780. PMID 7499401.
  2. ↑ 2.0 2.1 "Entrez Gene: HNRPH2 heterogeneous nuclear ribonucleoprotein H2 (H')".

Further reading



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