Thymosin beta-4, Y-chromosomal: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
WikiBot (talk | contribs)
Bots, Bureaucrats, bureaucrats, interwiki, nocaptcha, Administrators
57,550 edits
m Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +)
 
m Bot: HTTP→HTTPS (v470)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Thymosin beta-4, Y-chromosomal''' is a [[protein]] that in humans is encoded by the ''TMSB4Y'' [[gene]].<ref name="pmid9381176">{{cite journal | vauthors = Lahn BT, Page DC | title = Functional coherence of the human Y chromosome | journal = Science | volume = 278 | issue = 5338 | pages = 675–80 | date = October 1997 | pmid = 9381176 | pmc = | doi = 10.1126/science.278.5338.675 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TMSB4Y thymosin, beta 4, Y-linked| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9087| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein consists (in humans) of 44 [[amino acid]]s (msdkpgmaei ekfdksklkk tetqeknpls sketieqerq ages) MolWt 4881.<ref>https://www.ncbi.nlm.nih.gov/protein/NP_004193</ref>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Thymosin, beta 4, Y-linked
| HGNCid = 11882
| Symbol = TMSB4Y
| AltSymbols =; MGC26307; TB4Y
| OMIM = 400017
| ECnumber = 
| Homologene = 
| MGIid = 
| GeneAtlas_image1 = PBB_GE_TMSB4Y_206769_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}}
| Process = {{GNF_GO|id=GO:0007010 |text = cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0008064 |text = regulation of actin polymerization and/or depolymerization}} {{GNF_GO|id=GO:0042989 |text = sequestering of actin monomers}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9087
    | Hs_Ensembl = ENSG00000154620
    | Hs_RefseqProtein = NP_004193
    | Hs_RefseqmRNA = NM_004202
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = Y
    | Hs_GenLoc_start = 14324841
    | Hs_GenLoc_end = 14327298
    | Hs_Uniprot = O14604
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Thymosin, beta 4, Y-linked''', also known as '''TMSB4Y''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TMSB4Y thymosin, beta 4, Y-linked| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9087| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{PBB_Summary
| section_title =  
| summary_text = This gene lies within the male specific region of chromosome Y. Its homolog on chromosome X escapes X inactivation and encodes an actin sequestering protein.<ref name="entrez">{{cite web | title = Entrez Gene: TMSB4Y thymosin, beta 4, Y-linked| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9087| accessdate = }}</ref>
}}


==References==
This gene lies within the male specific region of [[Y chromosome|chromosome Y]]. Its homolog on [[X chromosome|chromosome X]] ([[thymosin beta-4]]) escapes X inactivation and encodes an [[actin]] sequestering protein.<ref name="entrez"/>
{{reflist|2}}
 
==Further reading==
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Yu FX, Lin SC, Morrison-Bogorad M, Atkinson MA, Yin HL | title = Thymosin beta 10 and thymosin beta 4 are both actin monomer sequestering proteins | journal = The Journal of Biological Chemistry | volume = 268 | issue = 1 | pages = 502–9 | date = January 1993 | pmid = 8416954 | doi =  }}
| citations =
* {{cite journal | vauthors = Li X, Zimmerman A, Copeland NG, Gilbert DJ, Jenkins NA, Yin HL | title = The mouse thymosin beta 4 gene: structure, promoter identification, and chromosome localization | journal = Genomics | volume = 32 | issue = 3 | pages = 388–94 | date = March 1996 | pmid = 8838802 | doi = 10.1006/geno.1996.0133 }}
*{{cite journal | author=Yu FX, Lin SC, Morrison-Bogorad M, ''et al.'' |title=Thymosin beta 10 and thymosin beta 4 are both actin monomer sequestering proteins. |journal=J. Biol. Chem. |volume=268 |issue= 1 |pages= 502-9 |year= 1993 |pmid= 8416954 |doi=  }}
* {{cite journal | vauthors =  | title = Toward a complete human genome sequence | journal = Genome Research | volume = 8 | issue = 11 | pages = 1097–108 | date = November 1998 | pmid = 9847074 | doi = 10.1101/gr.8.11.1097 }}
*{{cite journal | author=Li X, Zimmerman A, Copeland NG, ''et al.'' |title=The mouse thymosin beta 4 gene: structure, promoter identification, and chromosome localization. |journal=Genomics |volume=32 |issue= 3 |pages= 388-94 |year= 1997 |pmid= 8838802 |doi= 10.1006/geno.1996.0133 }}
* {{cite journal | vauthors = Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L, Brown LG, Repping S, Pyntikova T, Ali J, Bieri T, Chinwalla A, Delehaunty A, Delehaunty K, Du H, Fewell G, Fulton L, Fulton R, Graves T, Hou SF, Latrielle P, Leonard S, Mardis E, Maupin R, McPherson J, Miner T, Nash W, Nguyen C, Ozersky P, Pepin K, Rock S, Rohlfing T, Scott K, Schultz B, Strong C, Tin-Wollam A, Yang SP, Waterston RH, Wilson RK, Rozen S, Page DC | title = The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes | journal = Nature | volume = 423 | issue = 6942 | pages = 825–37 | date = June 2003 | pmid = 12815422 | doi = 10.1038/nature01722 }}
*{{cite journal | author=Lahn BT, Page DC |title=Functional coherence of the human Y chromosome. |journal=Science |volume=278 |issue= 5338 |pages= 675-80 |year= 1997 |pmid= 9381176 |doi= }}
* {{cite journal | vauthors = Torikai H, Akatsuka Y, Miyazaki M, Warren EH, Oba T, Tsujimura K, Motoyoshi K, Morishima Y, Kodera Y, Kuzushima K, Takahashi T | title = A novel HLA-A*3303-restricted minor histocompatibility antigen encoded by an unconventional open reading frame of human TMSB4Y gene | journal = Journal of Immunology | volume = 173 | issue = 11 | pages = 7046–54 | date = December 2004 | pmid = 15557202 | doi = 10.4049/jimmunol.173.11.7046 }}
*{{cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097-108 |year= 1999 |pmid= 9847074 |doi= }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, ''et al.'' |title=The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. |journal=Nature |volume=423 |issue= 6942 |pages= 825-37 |year= 2003 |pmid= 12815422 |doi= 10.1038/nature01722 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Torikai H, Akatsuka Y, Miyazaki M, ''et al.'' |title=A novel HLA-A*3303-restricted minor histocompatibility antigen encoded by an unconventional open reading frame of human TMSB4Y gene. |journal=J. Immunol. |volume=173 |issue= 11 |pages= 7046-54 |year= 2005 |pmid= 15557202 |doi= }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{protein-stub}}
{{WikiDoc Sources}}

Latest revision as of 02:15, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Thymosin beta-4, Y-chromosomal is a protein that in humans is encoded by the TMSB4Y gene.[1][2]

The protein consists (in humans) of 44 amino acids (msdkpgmaei ekfdksklkk tetqeknpls sketieqerq ages) MolWt 4881.[3]

Function

This gene lies within the male specific region of chromosome Y. Its homolog on chromosome X (thymosin beta-4) escapes X inactivation and encodes an actin sequestering protein.[2]

References

  1. ↑ Lahn BT, Page DC (October 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. doi:10.1126/science.278.5338.675. PMID 9381176.
  2. ↑ 2.0 2.1 "Entrez Gene: TMSB4Y thymosin, beta 4, Y-linked".
  3. ↑ https://www.ncbi.nlm.nih.gov/protein/NP_004193

Further reading

  • Yu FX, Lin SC, Morrison-Bogorad M, Atkinson MA, Yin HL (January 1993). "Thymosin beta 10 and thymosin beta 4 are both actin monomer sequestering proteins". The Journal of Biological Chemistry. 268 (1): 502–9. PMID 8416954.
  • Li X, Zimmerman A, Copeland NG, Gilbert DJ, Jenkins NA, Yin HL (March 1996). "The mouse thymosin beta 4 gene: structure, promoter identification, and chromosome localization". Genomics. 32 (3): 388–94. doi:10.1006/geno.1996.0133. PMID 8838802.
  • "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. November 1998. doi:10.1101/gr.8.11.1097. PMID 9847074.
  • Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L, Brown LG, Repping S, Pyntikova T, Ali J, Bieri T, Chinwalla A, Delehaunty A, Delehaunty K, Du H, Fewell G, Fulton L, Fulton R, Graves T, Hou SF, Latrielle P, Leonard S, Mardis E, Maupin R, McPherson J, Miner T, Nash W, Nguyen C, Ozersky P, Pepin K, Rock S, Rohlfing T, Scott K, Schultz B, Strong C, Tin-Wollam A, Yang SP, Waterston RH, Wilson RK, Rozen S, Page DC (June 2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature. 423 (6942): 825–37. doi:10.1038/nature01722. PMID 12815422.
  • Torikai H, Akatsuka Y, Miyazaki M, Warren EH, Oba T, Tsujimura K, Motoyoshi K, Morishima Y, Kodera Y, Kuzushima K, Takahashi T (December 2004). "A novel HLA-A*3303-restricted minor histocompatibility antigen encoded by an unconventional open reading frame of human TMSB4Y gene". Journal of Immunology. 173 (11): 7046–54. doi:10.4049/jimmunol.173.11.7046. PMID 15557202.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Retrieved from "https://www.wikidoc.org/index.php?title=Thymosin_beta-4,_Y-chromosomal&oldid=1423483"