UTY (gene): Difference between revisions

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{{Infobox_gene}}
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'''Histone demethylase UTY''' is an [[enzyme]] that in humans is encoded by the ''UTY'' [[gene]].<ref name="pmid8944031">{{cite journal |vauthors=Greenfield A, Scott D, Pennisi D, Ehrmann I, Ellis P, Cooper L, Simpson E, Koopman P | title = An H-YDb epitope is encoded by a novel mouse Y chromosome gene | journal = Nat Genet | volume = 14 | issue = 4 | pages = 474–478 |date=Jan 1997 | pmid = 8944031 | pmc =  | doi = 10.1038/ng1296-474 }}</ref><ref name="pmid9499428">{{cite journal |vauthors=Greenfield A, Carrel L, Pennisi D, Philippe C, Quaderi N, Siggers P, Steiner K, Tam PP, Monaco AP, Willard HF, Koopman P | title = The UTX gene escapes X inactivation in mice and humans | journal = Hum Mol Genet | volume = 7 | issue = 4 | pages = 737–742 |date=May 1998 | pmid = 9499428 | pmc =  | doi =10.1093/hmg/7.4.737 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UTY ubiquitously transcribed tetratricopeptide repeat gene, Y-linked| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7404| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Ubiquitously transcribed tetratricopeptide repeat gene, Y-linked
| HGNCid = 12638
| Symbol = UTY
| AltSymbols =; DKFZp686L12190; UTY1
| OMIM = 400009
| ECnumber =
| Homologene = 56022
| MGIid =
| GeneAtlas_image1 = PBB_GE_UTY_208067_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_UTY_211149_at_tn.png
  | GeneAtlas_image3 = PBB_GE_UTY_210322_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0005488 |text = binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7404
    | Hs_Ensembl = ENSG00000183878
    | Hs_RefseqProtein = NP_009056
    | Hs_RefseqmRNA = NM_007125
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = Y
    | Hs_GenLoc_start = 13869653
    | Hs_GenLoc_end = 14101947
    | Hs_Uniprot = O14607
    | Mm_EntrezGene = 
    | Mm_Ensembl =   
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Ubiquitously transcribed tetratricopeptide repeat gene, Y-linked''', also known as '''UTY''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UTY ubiquitously transcribed tetratricopeptide repeat gene, Y-linked| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7404| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein-protein interactions. This protein is a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. Alternative splicing results in multiple transcript variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: UTY ubiquitously transcribed tetratricopeptide repeat gene, Y-linked| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7404| accessdate = }}</ref>
| summary_text = This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein-protein interactions. This protein is a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. Alternative splicing results in multiple transcript variants encoding different isoforms.<ref name="entrez" />
}}
}}
==Interactions==
UTY (gene) has been shown to [[Protein-protein interaction|interact]] with [[TLE1]],<ref name=pmid9854018>{{cite journal |last=Grbavec |first=D |authorlink= |author2=Lo R |author3=Liu Y |author4=Greenfield A |author5=Stifani S  |date=Jan 1999 |title=Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms |journal=Biochem. J. |volume=337 |issue= 1|pages=13–7 |publisher= |location = ENGLAND| issn = 0264-6021| pmid = 9854018 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1219929 | doi=10.1042/0264-6021:3370013}}</ref> and WDR90<ref>{{Cite web|title = STRING: functional protein association networks|url = http://string-db.org/newstring_cgi/show_network_section.pl|website = string-db.org|accessdate = 2015-05-07}}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Greenfield A, Scott D, Pennisi D, ''et al.'' |title=An H-YDb epitope is encoded by a novel mouse Y chromosome gene. |journal=Nat. Genet. |volume=14 |issue= 4 |pages= 474-8 |year= 1997 |pmid= 8944031 |doi= 10.1038/ng1296-474 }}
*{{cite journal  |vauthors=Lahn BT, Page DC |title=Functional coherence of the human Y chromosome |journal=Science |volume=278 |issue= 5338 |pages= 675–680 |year= 1997 |pmid= 9381176 |doi=10.1126/science.278.5338.675 }}
*{{cite journal  | author=Lahn BT, Page DC |title=Functional coherence of the human Y chromosome. |journal=Science |volume=278 |issue= 5338 |pages= 675-80 |year= 1997 |pmid= 9381176 |doi= }}
*{{cite journal  | author=Grbavec D |title=Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms |journal=Biochem. J. |volume=337 |issue=  1|pages= 13–7 |year= 1999 |pmid= 9854018 |doi= 10.1042/0264-6021:3370013| pmc=1219929  |name-list-format=vanc| author2=Lo R  | author3=Liu Y  | display-authors=3  | last4=Greenfield  | first4=Andy  | last5=Stifani  | first5=Stefano }}
*{{cite journal  | author=Greenfield A, Carrel L, Pennisi D, ''et al.'' |title=The UTX gene escapes X inactivation in mice and humans. |journal=Hum. Mol. Genet. |volume=7 |issue= 4 |pages= 737-42 |year= 1998 |pmid= 9499428 |doi= }}
*{{cite journal  | author=Warren EH |title=The human UTY gene encodes a novel HLA-B8-restricted H-Y antigen |journal=J. Immunol. |volume=164 |issue= 5 |pages= 2807–14 |year= 2000 |pmid= 10679124 |doi= 10.4049/jimmunol.164.5.2807|name-list-format=vanc| author2=Gavin MA  | author3=Simpson E  | display-authors=3  | last4=Chandler  | first4=P  | last5=Page  | first5=DC  | last6=Disteche  | first6=C  | last7=Stankey  | first7=KA  | last8=Greenberg  | first8=PD  | last9=Riddell  | first9=SR }}
*{{cite journal  | author=Grbavec D, Lo R, Liu Y, ''et al.'' |title=Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms. |journal=Biochem. J. |volume=337 ( Pt 1) |issue=  |pages= 13-7 |year= 1999 |pmid= 9854018 |doi=  }}
*{{cite journal  |vauthors=Foresta C, Ferlin A, Moro E |title=Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility |journal=Hum. Mol. Genet. |volume=9 |issue= 8 |pages= 1161–1169 |year= 2000 |pmid= 10767340 |doi=10.1093/hmg/9.8.1161 }}
*{{cite journal  | author=Warren EH, Gavin MA, Simpson E, ''et al.'' |title=The human UTY gene encodes a novel HLA-B8-restricted H-Y antigen. |journal=J. Immunol. |volume=164 |issue= 5 |pages= 2807-14 |year= 2000 |pmid= 10679124 |doi=  }}
*{{cite journal  | author=Shen P |title=Population genetic implications from sequence variation in four Y chromosome genes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 13 |pages= 7354–7359 |year= 2000 |pmid= 10861003 |doi=10.1073/pnas.97.13.7354  | pmc=16549  |name-list-format=vanc| author2=Wang F  | author3=Underhill PA  | display-authors=3  | last4=Franco  | first4=C  | last5=Yang  | first5=WH  | last6=Roxas  | first6=A  | last7=Sung  | first7=R  | last8=Lin  | first8=AA  | last9=Hyman  | first9=RW }}
*{{cite journal  | author=Foresta C, Ferlin A, Moro E |title=Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility. |journal=Hum. Mol. Genet. |volume=9 |issue= 8 |pages= 1161-9 |year= 2000 |pmid= 10767340 |doi=  }}
*{{cite journal  | author=Vogt MH |title=UTY gene codes for an HLA-B60-restricted human male-specific minor histocompatibility antigen involved in stem cell graft rejection: characterization of the critical polymorphic amino acid residues for T-cell recognition |journal=Blood |volume=96 |issue= 9 |pages= 3126–32 |year= 2000 |pmid= 11049993 |doi= |name-list-format=vanc| author2=Goulmy E  | author3=Kloosterboer FM  | display-authors=3  | last4=Blokland  | first4=E  | last5=De Paus  | first5=RA  | last6=Willemze  | first6=R  | last7=Falkenburg  | first7=JH }}
*{{cite journal  | author=Shen P, Wang F, Underhill PA, ''et al.'' |title=Population genetic implications from sequence variation in four Y chromosome genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 13 |pages= 7354-9 |year= 2000 |pmid= 10861003 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Vogt MH, Goulmy E, Kloosterboer FM, ''et al.'' |title=UTY gene codes for an HLA-B60-restricted human male-specific minor histocompatibility antigen involved in stem cell graft rejection: characterization of the critical polymorphic amino acid residues for T-cell recognition. |journal=Blood |volume=96 |issue= 9 |pages= 3126-32 |year= 2000 |pmid= 11049993 |doi=  }}
*{{cite journal  | author=Gevaert K |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–569 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 |name-list-format=vanc| author2=Goethals M  | author3=Martens L  | display-authors=3  | last4=Van Damme  | first4=Jozef  | last5=Staes  | first5=An  | last6=Thomas  | first6=Grégoire R.  | last7=Vandekerckhove  | first7=Joël }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Skaletsky H |title=The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes |journal=Nature |volume=423 |issue= 6942 |pages= 825–837 |year= 2003 |pmid= 12815422 |doi= 10.1038/nature01722 |name-list-format=vanc| author2=Kuroda-Kawaguchi T  | author3=Minx PJ  | display-authors=3  | last4=Cordum  | first4=Holland S.  | last5=Hillier  | first5=Ladeana  | last6=Brown  | first6=Laura G.  | last7=Repping  | first7=Sjoerd  | last8=Pyntikova  | first8=Tatyana  | last9=Ali  | first9=Johar }}
*{{cite journal  | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal  |vauthors=Agate RJ, Choe M, Arnold AP |title=Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches |journal=Mol. Biol. Evol. |volume=21 |issue= 2 |pages= 384–396 |year= 2004 |pmid= 14660691 |doi= 10.1093/molbev/msh027 }}
*{{cite journal  | author=Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, ''et al.'' |title=The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. |journal=Nature |volume=423 |issue= 6942 |pages= 825-37 |year= 2003 |pmid= 12815422 |doi= 10.1038/nature01722 }}
*{{cite journal  |vauthors=Gerrard DT, Filatov DA |title=Positive and negative selection on mammalian Y chromosomes |journal=Mol. Biol. Evol. |volume=22 |issue= 6 |pages= 1423–1432 |year= 2005 |pmid= 15758204 |doi= 10.1093/molbev/msi128 }}
*{{cite journal  | author=Agate RJ, Choe M, Arnold AP |title=Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches. |journal=Mol. Biol. Evol. |volume=21 |issue= 2 |pages= 384-96 |year= 2004 |pmid= 14660691 |doi= 10.1093/molbev/msh027 }}
*{{cite journal  | author=Gerrard DT, Filatov DA |title=Positive and negative selection on mammalian Y chromosomes. |journal=Mol. Biol. Evol. |volume=22 |issue= 6 |pages= 1423-32 |year= 2005 |pmid= 15758204 |doi= 10.1093/molbev/msi128 }}
}}
}}
{{refend}}
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Revision as of 10:23, 17 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Histone demethylase UTY is an enzyme that in humans is encoded by the UTY gene.[1][2][3]

This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein-protein interactions. This protein is a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. Alternative splicing results in multiple transcript variants encoding different isoforms.[3]

Interactions

UTY (gene) has been shown to interact with TLE1,[4] and WDR90[5]

References

  1. ↑ Greenfield A, Scott D, Pennisi D, Ehrmann I, Ellis P, Cooper L, Simpson E, Koopman P (Jan 1997). "An H-YDb epitope is encoded by a novel mouse Y chromosome gene". Nat Genet. 14 (4): 474–478. doi:10.1038/ng1296-474. PMID 8944031.
  2. ↑ Greenfield A, Carrel L, Pennisi D, Philippe C, Quaderi N, Siggers P, Steiner K, Tam PP, Monaco AP, Willard HF, Koopman P (May 1998). "The UTX gene escapes X inactivation in mice and humans". Hum Mol Genet. 7 (4): 737–742. doi:10.1093/hmg/7.4.737. PMID 9499428.
  3. ↑ 3.0 3.1 "Entrez Gene: UTY ubiquitously transcribed tetratricopeptide repeat gene, Y-linked".
  4. ↑ Grbavec, D; Lo R; Liu Y; Greenfield A; Stifani S (Jan 1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". Biochem. J. ENGLAND. 337 (1): 13–7. doi:10.1042/0264-6021:3370013. ISSN 0264-6021. PMC 1219929. PMID 9854018.
  5. ↑ "STRING: functional protein association networks". string-db.org. Retrieved 2015-05-07.

Further reading



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