Alcoholic liver disease other diagnostic studies: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Alcoholic liver disease}} | {{Alcoholic liver disease}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}} {{MKA}} | ||
==Overview== | ==Overview== | ||
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* [[Alcoholic cirrhosis]] | * [[Alcoholic cirrhosis]] | ||
** [[Micronodular cirrhosis]] | ** [[Micronodular cirrhosis]] | ||
==Other diagnostic tests== | |||
Biomarkers for assessing fibrosis in patients with alcoholic liver disease:<ref name="pmid25356026">{{cite journal |vauthors=Mueller S, Seitz HK, Rausch V |title=Non-invasive diagnosis of alcoholic liver disease |journal=World J. Gastroenterol. |volume=20 |issue=40 |pages=14626–41 |year=2014 |pmid=25356026 |pmc=4209529 |doi=10.3748/wjg.v20.i40.14626 |url=}}</ref> | |||
*FibroTest<ref name="pmid19053048">{{cite journal |vauthors=Naveau S, Gaudé G, Asnacios A, Agostini H, Abella A, Barri-Ova N, Dauvois B, Prévot S, Ngo Y, Munteanu M, Balian A, Njiké-Nakseu M, Perlemuter G, Poynard T |title=Diagnostic and prognostic values of noninvasive biomarkers of fibrosis in patients with alcoholic liver disease |journal=Hepatology |volume=49 |issue=1 |pages=97–105 |year=2009 |pmid=19053048 |doi=10.1002/hep.22576 |url=}}</ref> | |||
**Based on α2-macroglobulin, haptoglobin, GGT, ApoA1 and bilirubin | |||
*FibrometerA<ref name="pmid15704051">{{cite journal |vauthors=Naveau S, Raynard B, Ratziu V, Abella A, Imbert-Bismut F, Messous D, Beuzen F, Capron F, Thabut D, Munteanu M, Chaput JC, Poynard T |title=Biomarkers for the prediction of liver fibrosis in patients with chronic alcoholic liver disease |journal=Clin. Gastroenterol. Hepatol. |volume=3 |issue=2 |pages=167–74 |year=2005 |pmid=15704051 |doi= |url=}}</ref> | |||
**Based on prothrombin time, α2-macroglobulin, hyaluronic acid and age | |||
*Hepascore<ref name="pmid16317693">{{cite journal |vauthors=Calès P, Oberti F, Michalak S, Hubert-Fouchard I, Rousselet MC, Konaté A, Gallois Y, Ternisien C, Chevailler A, Lunel F |title=A novel panel of blood markers to assess the degree of liver fibrosis |journal=Hepatology |volume=42 |issue=6 |pages=1373–81 |year=2005 |pmid=16317693 |doi=10.1002/hep.20935 |url=}}</ref> | |||
**Combines bilirubin, GGT, α2-macroglobulin, hyaluronic acid , age and gender | |||
==2010 AASLD/ACG Alcoholic Liver Disease Guidelines (DO NOT EDIT)<ref name="urlwww.aasld.org">{{cite web |url=http://www.aasld.org/practiceguidelines/Documents/Bookmarked%20Practice%20Guidelines/AlcoholicLiverDisease1-2010.pdf |title=www.aasld.org |format= |work= |accessdate=2012-10-27}}</ref>== | ==2010 AASLD/ACG Alcoholic Liver Disease Guidelines (DO NOT EDIT)<ref name="urlwww.aasld.org">{{cite web |url=http://www.aasld.org/practiceguidelines/Documents/Bookmarked%20Practice%20Guidelines/AlcoholicLiverDisease1-2010.pdf |title=www.aasld.org |format= |work= |accessdate=2012-10-27}}</ref>== | ||
Revision as of 20:50, 21 December 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: M. Khurram Afzal, MD [2]
Overview
Liver biopsy is used to confirm the diagnosis when alcoholic hepatitis is suspected, and to help in guiding medical treatment. Microscopic findings on biopsy that indicate alcoholic hepatitis are: polymorphonuclear infiltration of cells, hepatic necrosis, ballooning hepatocytes, Mallory bodies within cells, and perivenular and perisinusoidal fibrosis.
Other Diagnostic Studies
Liver Biopsy
- Fatty liver
- Macrovesicular fat
- Alcoholic hepatitis
- Polymorphonuclear infiltration
- Hepatic necrosis
- Mallory bodies in hepatocytes
- Perivenular and perisinusoidal fibrosis
- Ballooning hepatocytes
- Steatosis
- Alcoholic cirrhosis
Other diagnostic tests
Biomarkers for assessing fibrosis in patients with alcoholic liver disease:[1]
- FibroTest[2]
- Based on α2-macroglobulin, haptoglobin, GGT, ApoA1 and bilirubin
- FibrometerA[3]
- Based on prothrombin time, α2-macroglobulin, hyaluronic acid and age
- Hepascore[4]
- Combines bilirubin, GGT, α2-macroglobulin, hyaluronic acid , age and gender
2010 AASLD/ACG Alcoholic Liver Disease Guidelines (DO NOT EDIT)[5]
Biopsy : Guidelines (DO NOT EDIT)[5]
| Class I |
| 1. " For patients with a clinical diagnosis of severe alcoholic hepatitis (AH) for whom medical treatment is contemplated, or for those in whom reasonable uncertainty exists regarding the underlying diagnosis, a liver biopsy should be considered. This decision will depend on local expertise and ability in performing a liver biopsy in patients with coagulopathy, the patient’s severity of illness, and the type of therapy under consideration (Level of evidence: C) " |
References
- ↑ Mueller S, Seitz HK, Rausch V (2014). "Non-invasive diagnosis of alcoholic liver disease". World J. Gastroenterol. 20 (40): 14626–41. doi:10.3748/wjg.v20.i40.14626. PMC 4209529. PMID 25356026.
- ↑ Naveau S, Gaudé G, Asnacios A, Agostini H, Abella A, Barri-Ova N, Dauvois B, Prévot S, Ngo Y, Munteanu M, Balian A, Njiké-Nakseu M, Perlemuter G, Poynard T (2009). "Diagnostic and prognostic values of noninvasive biomarkers of fibrosis in patients with alcoholic liver disease". Hepatology. 49 (1): 97–105. doi:10.1002/hep.22576. PMID 19053048.
- ↑ Naveau S, Raynard B, Ratziu V, Abella A, Imbert-Bismut F, Messous D, Beuzen F, Capron F, Thabut D, Munteanu M, Chaput JC, Poynard T (2005). "Biomarkers for the prediction of liver fibrosis in patients with chronic alcoholic liver disease". Clin. Gastroenterol. Hepatol. 3 (2): 167–74. PMID 15704051.
- ↑ Calès P, Oberti F, Michalak S, Hubert-Fouchard I, Rousselet MC, Konaté A, Gallois Y, Ternisien C, Chevailler A, Lunel F (2005). "A novel panel of blood markers to assess the degree of liver fibrosis". Hepatology. 42 (6): 1373–81. doi:10.1002/hep.20935. PMID 16317693.
- ↑ 5.0 5.1 "www.aasld.org" (PDF). Retrieved 2012-10-27.