Diaphragmatic hernia pathophysiology: Difference between revisions
Jump to navigation
Jump to search
Ahmed Younes (talk | contribs) (Created page with " __NOTOC__ {{Diaphragmatic hernia}} {{CMG}};{{AE}}{{AY}} ==Overview== ==== ==References== {{Reflist|2}}") |
Ahmed Younes (talk | contribs) No edit summary |
||
| Line 6: | Line 6: | ||
==Overview== | ==Overview== | ||
==== | ==Pathophysiology== | ||
*The herniated viscera decrease the area needed by the lung to develop appropriately.<ref name="pmid8982563">{{cite journal |vauthors=Langham MR, Kays DW, Ledbetter DJ, Frentzen B, Sanford LL, Richards DS |title=Congenital diaphragmatic hernia. Epidemiology and outcome |journal=Clin Perinatol |volume=23 |issue=4 |pages=671–88 |year=1996 |pmid=8982563 |doi= |url=}}</ref> | |||
*According to the degree of herniation, the degree of pulmonary hypoplasia is determined. | |||
*The herniated [[viscera]] impairs the development of the [[bronchial tree]]. | |||
*As a consequence, the [[alveoli]] development is also slowed.<ref name="pmid20610190">{{cite journal |vauthors=Keijzer R, Puri P |title=Congenital diaphragmatic hernia |journal=Semin. Pediatr. Surg. |volume=19 |issue=3 |pages=180–5 |year=2010 |pmid=20610190 |doi=10.1053/j.sempedsurg.2010.03.001 |url=}}</ref> | |||
*The development of the pulmonary artery tree is halted too resulting in excessive masculinization of the arteries. | |||
*The increased pulmonary pressure leads to increased pressure on the [[right ventricle]] leading to the development of a [[right to left shunt]]. | |||
*As most of the cases of diaphragmatic hernias are unilateral, the pulmonary hypoplasia is also usually unilateral, but it can be bilateral if the [[mediastinum]] is pushed by a massive unilateral hernia. | |||
*The abnormal alveolar development can lead to [[hypoxemia]] leading to pulmonary vasoconstriction which aggravates the condition. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 16:31, 22 December 2017
|
Diaphragmatic hernia Main page |
|
Diagnosis |
|---|
|
Treatment |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Ahmed Younes M.B.B.CH [2]
Overview
Pathophysiology
- The herniated viscera decrease the area needed by the lung to develop appropriately.[1]
- According to the degree of herniation, the degree of pulmonary hypoplasia is determined.
- The herniated viscera impairs the development of the bronchial tree.
- As a consequence, the alveoli development is also slowed.[2]
- The development of the pulmonary artery tree is halted too resulting in excessive masculinization of the arteries.
- The increased pulmonary pressure leads to increased pressure on the right ventricle leading to the development of a right to left shunt.
- As most of the cases of diaphragmatic hernias are unilateral, the pulmonary hypoplasia is also usually unilateral, but it can be bilateral if the mediastinum is pushed by a massive unilateral hernia.
- The abnormal alveolar development can lead to hypoxemia leading to pulmonary vasoconstriction which aggravates the condition.
References
- ↑ Langham MR, Kays DW, Ledbetter DJ, Frentzen B, Sanford LL, Richards DS (1996). "Congenital diaphragmatic hernia. Epidemiology and outcome". Clin Perinatol. 23 (4): 671–88. PMID 8982563.
- ↑ Keijzer R, Puri P (2010). "Congenital diaphragmatic hernia". Semin. Pediatr. Surg. 19 (3): 180–5. doi:10.1053/j.sempedsurg.2010.03.001. PMID 20610190.