Ascites overview: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
Ascites is excess accumulation of fluid in the [[peritoneal cavity]]. The fluid can be defined as a [[transudate]] or an [[exudate]]. Amounts of up to 25 liters are fully possible. Roughly, [[transudate]]s are a result of increased pressure in the [[Hepatic portal vein|portal vein]] (> 8 mmHg), such as [[cirrhosis]]; while [[Exudate|exudates]] are actively secreted fluid due to [[inflammation]] or [[malignancy]]. The most useful measure is the difference between ascitic and [[serum albumin]] concentrations. A difference of less than 1.1 g/dl (10 g/L) implies an [[exudate]]. There is no [[genetic]] background for ascites. On [[gross pathology]], clear to pale yellow fluid accumulation in [[Peritoneal cavity|peritoneal space]] are characteristic findings of ascites under normal condition, but it may be [[Chylous ascites|chylous]], psudochylous, or bloody. | |||
==Causes== | ==Causes== | ||
==Differentiating Ascites from Other Diseases== | ==Differentiating Ascites from Other Diseases== | ||
Revision as of 21:34, 10 January 2018
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Ascites Microchapters |
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Diagnosis |
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Treatment |
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Ascites overview On the Web |
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American Roentgen Ray Society Images of Ascites overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:
Overview
Historical Perspective
About 20 BC, Aulus Cornelius Celsus (A.D. 30), a Roman encyclopedist explained in his book "De Medicina" three different types of fluid accumulation under the skin; which was called hydrops by Greeks. Celsus postulated that ascites is mostly secondary to quartan fever (malaria) in Rome. The principles of treatment for ascites were explained as thirst, rest, and abstinence. Drinking less fluid and sweating more, not with exercise, but with heated sand, or in the sweating-room, or with a dry oven and such- like were the other alternative therapies. In 1827, Ludwig van Beethoven involved in ascites and underwent large volumes of paracenteses. His physician write about him as "Beethoven had almost immediate relief, and when he saw the stream of water [during paracentesis], cried out that the operation made him think of Moses, who struck the rock with his staff and made the water gush forth."
Classification
Ascites may be classified according to etiology into four groups include portal hypertension, hypoalbuminemia, peritoneal disease, and other diseases. Ascites is also classified based on the Serum-ascites albumin gradient (SAAG) as two subtypes include transudate - SAAG > 1.1 g/dL and exudate - SAAG < 1.1 g/dL.
Pathophysiology
Ascites is excess accumulation of fluid in the peritoneal cavity. The fluid can be defined as a transudate or an exudate. Amounts of up to 25 liters are fully possible. Roughly, transudates are a result of increased pressure in the portal vein (> 8 mmHg), such as cirrhosis; while exudates are actively secreted fluid due to inflammation or malignancy. The most useful measure is the difference between ascitic and serum albumin concentrations. A difference of less than 1.1 g/dl (10 g/L) implies an exudate. There is no genetic background for ascites. On gross pathology, clear to pale yellow fluid accumulation in peritoneal space are characteristic findings of ascites under normal condition, but it may be chylous, psudochylous, or bloody.