Hepatic encephalopathy historical perspective: Difference between revisions
No edit summary |
|||
| Line 2: | Line 2: | ||
{{Hepatic encephalopathy}} | {{Hepatic encephalopathy}} | ||
{{CMG}};{{AE}}{{MMJ}} | {{CMG}};{{AE}}{{MMJ}} | ||
== Overview == | == Overview == | ||
Revision as of 15:36, 17 January 2018
|
Hepatic encephalopathy Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Hepatic encephalopathy historical perspective On the Web |
|
American Roentgen Ray Society Images of Hepatic encephalopathy historical perspective |
|
Risk calculators and risk factors for Hepatic encephalopathy historical perspective |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]
Overview
Hepatic encephalopathy was first discovered by GB. Morgagni, an italian anatomist, in the 18th century who described a case of hepatic encephalopathy. He reported the history of a noble from Venice who was an alcohol misuser in the past. The patient first developed ascites and some episodes of agitation, and then he developed prolonged episodes of somnolence and delirium. Friedrich Theodor von Frerichs, in the 19th century clearly reported the existence of episodes of delirium, somnolence and coma in liver disease in his famous treatise on liver disease. In 1954, Dame Sheila Patricia Violet Sherlock and her disciples in London gave a definite improvement in the description of the clinical findings, the pathophysiology and treatment of hepatic encephalopathy. For the first time she confirmed the role of hyperammonaemia in the pathophysiology of the hepatic encephalopathy and the role of gut microbiota that could be modulated by antibiotics to revert coma. In 1954, Dame Sheila Patricia Violet Sherlock and her disciples in London gave a definite improvement in the description of the treatment of hepatic encephalopathy.
Historical Perspective
Discovery
- Hepatic encephalopathy was first discovered by GB. Morgagni, an italian anatomist, in the 18th century who described a case of hepatic encephalopathy. He reported the history of a noble from Venice who was an alcohol misuser in the past. The patient first developed ascites and some episodes of agitation, and then he developed prolonged episodes of somnolence and delirium.[1]
- Friedrich Theodor von Frerichs, in the 19th century clearly reported the existence of episodes of delirium, somnolence and coma in liver disease in his famous treatise on liver disease.[1]
- In 1954, Dame Sheila Patricia Violet Sherlock and her disciples in London gave a definite improvement in the description of the clinical findings, the pathophysiology and treatment of hepatic encephalopathy. For the first time she confirmed the role of hyperammonaemia in the pathophysiology of the hepatic encephalopathy and the role of gut microbiota that could be modulated by antibiotics to revert coma.[2]
Landmark Events in the Development of Treatment Strategies
- In 1954, Dame Sheila Patricia Violet Sherlock and her disciples in London gave a definite improvement in the description of the treatment of hepatic encephalopathy.[2]
References
- ↑ 1.0 1.1 Amodio P (2015). "Hepatic encephalopathy: historical remarks". J Clin Exp Hepatol. 5 (Suppl 1): S4–6. doi:10.1016/j.jceh.2014.12.005. PMC 4442853. PMID 26041956.
- ↑ 2.0 2.1 SHERLOCK S, SUMMERSKILL WH, WHITE LP, PHEAR EA (1954). "Portal-systemic encephalopathy; neurological complications of liver disease". Lancet. 267 (6836): 454–7. PMID 13193045.