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| == Pathophysiology == | | == Pathophysiology == |
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| === Chronic inflammation: ===
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| * It is understood that gallbladder cancer is the result of chronic irritation or inflmation of the gallbladder | |
| * In most of patients (>75%), the nidus of this chronic inflammation is gallstones.
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| *Gallbladder cancer affects most commonly females 2-3 times than males<ref name="pmid11760569">{{cite journal |vauthors=Lazcano-Ponce EC, Miquel JF, Muñoz N, Herrero R, Ferrecio C, Wistuba II, Alonso de Ruiz P, Aristi Urista G, Nervi F |title=Epidemiology and molecular pathology of gallbladder cancer |journal=CA Cancer J Clin |volume=51 |issue=6 |pages=349–64 |year=2001 |pmid=11760569 |doi= |url=}}</ref>
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| *In carcinogenesis of gallbladder cancer, Chronic inflammation is directly propotional to malignant transformation
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| *Chronic inflammation leads to deoxyribonucleic acid (DNA) damage, Releasing cytokines and growth factor in response to inflamation predispose to malignant transformation
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| == References == | | == References == |
| <references /> | | <references /> |
Revision as of 18:54, 18 January 2018
Overview
It is thought that gallbladder cancer is the result of chronic irritation of the gallbladder mucosa over a duration of years may predispose to malignant transformation.
Pathophysiology
References