Gallbladder cancer pathophysiology: Difference between revisions
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== Pathophysiology == | == Pathophysiology == | ||
* It is understood that gallbladder cancer is the result of two different independent biological pathways | * It is understood that gallbladder cancer is the result of two different independent biological pathways | ||
** 1) The most common pathway is a dysplasia-carcinoma which is arising from metaplastic epithelium. It's a process that would require a period of approximately 10 years to devlop.<ref name="pmid16724345">{{cite journal |vauthors=Roa I, de Aretxabala X, Araya JC, Roa J |title=Preneoplastic lesions in gallbladder cancer |journal=J Surg Oncol |volume=93 |issue=8 |pages=615–23 |year=2006 |pmid=16724345 |doi=10.1002/jso.20527 |url=}}</ref> | ** 1) The most common pathway is a dysplasia-carcinoma which is arising from metaplastic epithelium. It's a process that would require a period of approximately 10 years to devlop.<ref name="pmid16724345">{{cite journal |vauthors=Roa I, de Aretxabala X, Araya JC, Roa J |title=Preneoplastic lesions in gallbladder cancer |journal=J Surg Oncol |volume=93 |issue=8 |pages=615–23 |year=2006 |pmid=16724345 |doi=10.1002/jso.20527 |url=}}</ref> | ||
** 2) the second most common pathway is an adenoma-carcinoma sequence.<ref name="pmid167243452">{{cite journal |vauthors=Roa I, de Aretxabala X, Araya JC, Roa J |title=Preneoplastic lesions in gallbladder cancer |journal=J Surg Oncol |volume=93 |issue=8 |pages=615–23 |year=2006 |pmid=16724345 |doi=10.1002/jso.20527 |url=}}</ref> | ** 2) the second most common pathway is an adenoma-carcinoma sequence.<ref name="pmid167243452">{{cite journal |vauthors=Roa I, de Aretxabala X, Araya JC, Roa J |title=Preneoplastic lesions in gallbladder cancer |journal=J Surg Oncol |volume=93 |issue=8 |pages=615–23 |year=2006 |pmid=16724345 |doi=10.1002/jso.20527 |url=}}</ref> | ||
Revision as of 19:38, 19 January 2018
Overview
It is thought that gallbladder cancer is the result of chronic irritation of the gallbladder mucosa over a duration of years may predispose to malignant transformation.
Pathophysiology
- It is understood that gallbladder cancer is the result of two different independent biological pathways
References
- ↑ Roa I, de Aretxabala X, Araya JC, Roa J (2006). "Preneoplastic lesions in gallbladder cancer". J Surg Oncol. 93 (8): 615–23. doi:10.1002/jso.20527. PMID 16724345.
- ↑ Roa I, de Aretxabala X, Araya JC, Roa J (2006). "Preneoplastic lesions in gallbladder cancer". J Surg Oncol. 93 (8): 615–23. doi:10.1002/jso.20527. PMID 16724345.