Polycythemia vera risk factors: Difference between revisions
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* Old age ( 65 year old and older) | * Old age ( 65 year old and older) | ||
The risk factors for the development of [[myelofibrosis]] from polycythemia vera include: | The risk factors for the development of [[myelofibrosis]] from polycythemia vera include<ref name="pmid27884974">{{cite journal| author=Vannucchi AM| title=From leeches to personalized medicine: evolving concepts in the management of polycythemia vera. | journal=Haematologica | year= 2017 | volume= 102 | issue= 1 | pages= 18-29 | pmid=27884974 | doi=10.3324/haematol.2015.129155 | pmc=5210229 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27884974 }} </ref>: | ||
*Increased age | *Increased age | ||
*Leukocytosis | *Leukocytosis | ||
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*Splenomegaly | *Splenomegaly | ||
The risk factors for the development of [[acute myeloid leukemia]] from polycythemia vera include: | The risk factors for the development of [[acute myeloid leukemia]] from polycythemia vera include<ref name="pmid27884974">{{cite journal| author=Vannucchi AM| title=From leeches to personalized medicine: evolving concepts in the management of polycythemia vera. | journal=Haematologica | year= 2017 | volume= 102 | issue= 1 | pages= 18-29 | pmid=27884974 | doi=10.3324/haematol.2015.129155 | pmc=5210229 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27884974 }} </ref>: | ||
*Increased age | *Increased age | ||
*Leukocytosis | *Leukocytosis | ||
*Splenomegaly | *Splenomegaly | ||
*Abnormal karyotype | *Abnormal karyotype | ||
==References== | ==References== | ||
Revision as of 01:30, 21 January 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2] Shyam Patel [3]
Overview
Common risk factors in the development of polycythemia vera are a positive history of thrombotic event and old age ( 65 year old and older).[1]
Common Risk Factors
Common risk factors in the development of polycythemia vera are:[1]
- A positive history of thrombotic event
- Old age ( 65 year old and older)
The risk factors for the development of myelofibrosis from polycythemia vera include[2]:
- Increased age
- Leukocytosis
- High variant allele frequency of the JAK2 mutation (high allele burden)
- Thrombocytosis
- Splenomegaly
The risk factors for the development of acute myeloid leukemia from polycythemia vera include[2]:
- Increased age
- Leukocytosis
- Splenomegaly
- Abnormal karyotype
References
- ↑ 1.0 1.1 Barbui T, Carobbio A, Rumi E, Finazzi G, Gisslinger H, Rodeghiero F; et al. (2014). "In contemporary patients with polycythemia vera, rates of thrombosis and risk factors delineate a new clinical epidemiology". Blood. 124 (19): 3021–3. doi:10.1182/blood-2014-07-591610. PMID 25377561.
- ↑ 2.0 2.1 Vannucchi AM (2017). "From leeches to personalized medicine: evolving concepts in the management of polycythemia vera". Haematologica. 102 (1): 18–29. doi:10.3324/haematol.2015.129155. PMC 5210229. PMID 27884974.