Polycythemia vera risk factors: Difference between revisions
Jump to navigation
Jump to search
Shyam Patel (talk | contribs) |
Shyam Patel (talk | contribs) No edit summary |
||
| Line 7: | Line 7: | ||
==Common Risk Factors== | ==Common Risk Factors== | ||
Common risk factors in the development of polycythemia vera are:<ref name="pmid25377561">{{cite journal| author=Barbui T, Carobbio A, Rumi E, Finazzi G, Gisslinger H, Rodeghiero F et al.| title=In contemporary patients with polycythemia vera, rates of thrombosis and risk factors delineate a new clinical epidemiology. | journal=Blood | year= 2014 | volume= 124 | issue= 19 | pages= 3021-3 | pmid=25377561 | doi=10.1182/blood-2014-07-591610 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25377561 }} </ref> | Common risk factors in the development of polycythemia vera are:<ref name="pmid25377561">{{cite journal| author=Barbui T, Carobbio A, Rumi E, Finazzi G, Gisslinger H, Rodeghiero F et al.| title=In contemporary patients with polycythemia vera, rates of thrombosis and risk factors delineate a new clinical epidemiology. | journal=Blood | year= 2014 | volume= 124 | issue= 19 | pages= 3021-3 | pmid=25377561 | doi=10.1182/blood-2014-07-591610 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25377561 }} </ref> | ||
* A | *A history of thrombotic event | ||
* Old age ( 65 year old and older) | *Old age ( 65 year old and older) | ||
*Family history of polycythemia vera: First-degree relatives of patients with polycythemia vera have a 5 to 7-fold higher risk for development of a myeloproliferative neoplasm.The cumulative risk of developing [[myelofibrosis]] is 6% at 10 years, 14% at 15 years, and 26% at 20 years from the initial diagnosis of polycythemia vera.<ref name="pmid27884974">{{cite journal| author=Vannucchi AM| title=From leeches to personalized medicine: evolving concepts in the management of polycythemia vera. | journal=Haematologica | year= 2017 | volume= 102 | issue= 1 | pages= 18-29 | pmid=27884974 | doi=10.3324/haematol.2015.129155 | pmc=5210229 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27884974 }} </ref> | |||
*Ashkenazi Jewish descent: | |||
The risk factors for the development of [[myelofibrosis]] from polycythemia vera include<ref name="pmid27884974">{{cite journal| author=Vannucchi AM| title=From leeches to personalized medicine: evolving concepts in the management of polycythemia vera. | journal=Haematologica | year= 2017 | volume= 102 | issue= 1 | pages= 18-29 | pmid=27884974 | doi=10.3324/haematol.2015.129155 | pmc=5210229 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27884974 }} </ref>: | The risk factors for the development of [[myelofibrosis]] from polycythemia vera include<ref name="pmid27884974">{{cite journal| author=Vannucchi AM| title=From leeches to personalized medicine: evolving concepts in the management of polycythemia vera. | journal=Haematologica | year= 2017 | volume= 102 | issue= 1 | pages= 18-29 | pmid=27884974 | doi=10.3324/haematol.2015.129155 | pmc=5210229 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27884974 }} </ref>: | ||
Revision as of 01:36, 21 January 2018
|
Polycythemia vera Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Polycythemia vera risk factors On the Web |
|
American Roentgen Ray Society Images of Polycythemia vera risk factors |
|
Risk calculators and risk factors for Polycythemia vera risk factors |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2] Shyam Patel [3]
Overview
Common risk factors in the development of polycythemia vera are a positive history of thrombotic event and old age ( 65 year old and older).[1]
Common Risk Factors
Common risk factors in the development of polycythemia vera are:[1]
- A history of thrombotic event
- Old age ( 65 year old and older)
- Family history of polycythemia vera: First-degree relatives of patients with polycythemia vera have a 5 to 7-fold higher risk for development of a myeloproliferative neoplasm.The cumulative risk of developing myelofibrosis is 6% at 10 years, 14% at 15 years, and 26% at 20 years from the initial diagnosis of polycythemia vera.[2]
- Ashkenazi Jewish descent:
The risk factors for the development of myelofibrosis from polycythemia vera include[2]:
- Increased age
- Leukocytosis
- High variant allele frequency of the JAK2 mutation (high allele burden)
- Thrombocytosis
- Splenomegaly
The risk factors for the development of acute myeloid leukemia from polycythemia vera include[2]:
- Increased age
- Leukocytosis
- Splenomegaly
- Abnormal karyotype
References
- ↑ 1.0 1.1 Barbui T, Carobbio A, Rumi E, Finazzi G, Gisslinger H, Rodeghiero F; et al. (2014). "In contemporary patients with polycythemia vera, rates of thrombosis and risk factors delineate a new clinical epidemiology". Blood. 124 (19): 3021–3. doi:10.1182/blood-2014-07-591610. PMID 25377561.
- ↑ 2.0 2.1 2.2 Vannucchi AM (2017). "From leeches to personalized medicine: evolving concepts in the management of polycythemia vera". Haematologica. 102 (1): 18–29. doi:10.3324/haematol.2015.129155. PMC 5210229. PMID 27884974.