Gallbladder cancer laboratory tests: Difference between revisions
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==Overview== | ==Overview== | ||
There are no diagnostic laboratory findings associated with gallbladder cancer | There are no [[diagnostic]] laboratory findings associated with [[gallbladder cancer]] | ||
==Laboratory tests<ref name="pmid2335386">{{cite journal |vauthors=Strom BL, Maislin G, West SL, Atkinson B, Herlyn M, Saul S, Rodriguez-Martinez HA, Rios-Dalenz J, Iliopoulos D, Soloway RD |title=Serum CEA and CA 19-9: potential future diagnostic or screening tests for gallbladder cancer? |journal=Int. J. Cancer |volume=45 |issue=5 |pages=821–4 |year=1990 |pmid=2335386 |doi= |url=}}</ref> <ref name="pmid21573879">{{cite journal |vauthors=Rana S, Dutta U, Kochhar R, Rana SV, Gupta R, Pal R, Jain K, Srinivasan R, Nagi B, Nain CK, Singh K |title=Evaluation of CA 242 as a tumor marker in gallbladder cancer |journal=J Gastrointest Cancer |volume=43 |issue=2 |pages=267–71 |year=2012 |pmid=21573879 |doi=10.1007/s12029-011-9288-7 |url=}}</ref>== | ==Laboratory tests<ref name="pmid2335386">{{cite journal |vauthors=Strom BL, Maislin G, West SL, Atkinson B, Herlyn M, Saul S, Rodriguez-Martinez HA, Rios-Dalenz J, Iliopoulos D, Soloway RD |title=Serum CEA and CA 19-9: potential future diagnostic or screening tests for gallbladder cancer? |journal=Int. J. Cancer |volume=45 |issue=5 |pages=821–4 |year=1990 |pmid=2335386 |doi= |url=}}</ref> <ref name="pmid21573879">{{cite journal |vauthors=Rana S, Dutta U, Kochhar R, Rana SV, Gupta R, Pal R, Jain K, Srinivasan R, Nagi B, Nain CK, Singh K |title=Evaluation of CA 242 as a tumor marker in gallbladder cancer |journal=J Gastrointest Cancer |volume=43 |issue=2 |pages=267–71 |year=2012 |pmid=21573879 |doi=10.1007/s12029-011-9288-7 |url=}}</ref>== | ||
* Laboratory studies are usually nondiagnostic | * Laboratory studies are usually nondiagnostic | ||
* An elevated alkaline phosphatase or serum bilirubin can be associated with bile duct obstruction. | * An elevated [[alkaline phosphatase]] or serum [[bilirubin]] can be associated with [[bile duct]] [[obstruction]]. | ||
* Serum tumor | * Serum [[tumor marker]]<nowiki/>s including carcinoembryonic antigen ([[CEA]]) or [[carbohydrate]] [[antigen]] 19-9 are frequently elevated, but they're no longer diagnostically useful because they lack [[specificity]] and [[sensitivity]]. | ||
* CA 242 is a tumor marker for gallbladder cancer and performs better than CEA and CA 19-9 | * CA 242 is a tumor marker for gallbladder cancer and performs better than CEA and CA 19-9 | ||
* However, if a tumor marker is observed to be elevated preoperatively, serial assay after resection may useful resource within the analysis of chronic or recurrent disease. | * However, if a tumor marker is observed to be elevated preoperatively, serial assay after resection may useful resource within the analysis of chronic or recurrent disease. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
There are no diagnostic laboratory findings associated with gallbladder cancer
Laboratory tests[1] [2]
- Laboratory studies are usually nondiagnostic
- An elevated alkaline phosphatase or serum bilirubin can be associated with bile duct obstruction.
- Serum tumor markers including carcinoembryonic antigen (CEA) or carbohydrate antigen 19-9 are frequently elevated, but they're no longer diagnostically useful because they lack specificity and sensitivity.
- CA 242 is a tumor marker for gallbladder cancer and performs better than CEA and CA 19-9
- However, if a tumor marker is observed to be elevated preoperatively, serial assay after resection may useful resource within the analysis of chronic or recurrent disease.
References
- ↑ Strom BL, Maislin G, West SL, Atkinson B, Herlyn M, Saul S, Rodriguez-Martinez HA, Rios-Dalenz J, Iliopoulos D, Soloway RD (1990). "Serum CEA and CA 19-9: potential future diagnostic or screening tests for gallbladder cancer?". Int. J. Cancer. 45 (5): 821–4. PMID 2335386.
- ↑ Rana S, Dutta U, Kochhar R, Rana SV, Gupta R, Pal R, Jain K, Srinivasan R, Nagi B, Nain CK, Singh K (2012). "Evaluation of CA 242 as a tumor marker in gallbladder cancer". J Gastrointest Cancer. 43 (2): 267–71. doi:10.1007/s12029-011-9288-7. PMID 21573879.