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| '''Spondyloarthropathies''' are inflammatory joint diseases associated with the [[Major_histocompatibility_complex|MHC]] class I molecule [[HLA-B27]]. The term '''seronegative spondylarthropathy''' is used by medical practitioners because this set of conditions may mimic rheumatoid diseases such as [[rheumatoid arthritis]], but [[serological]] (blood) tests are typically negative for [[rheumatoid factor|rheumatoid factor (RhF)]].
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| Subgroups (with increased HLA-B27 frequency) are:
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| *[[ankylosing spondylitis]] Caucasians (AS, 92%),
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| *[[ankylosing spondylitis]] African-Americans (AS, 50%),
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| *[[reactive arthritis]] (Reiter's syndrome) (RS, 60-80%),
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| *[[enteropathic]] arthritis associated with [[inflammatory bowel disease]] (IBD, 60%),
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| *[[Psoriatic arthritis]] (60%),
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| *isolated acute anterior uveitis (AAU, iritis or iridocyclitis, 50%), and
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| *undifferentiated SpA (USpA, 20-25%).
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| [[Whipple disease]] and [[Behçet disease]] may also be linked to HLA-B27, as may undifferentiated spondyloarthropathy.
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| *Note: One of the causes of erosive or destructive spondyloarthropathy is [[Hyperparathyroidism|tertiary hyperparathyroidism]].<ref name="pmid2712794">{{cite journal |vauthors=Adler JS, Cameron DC |title=Erosive spondylo-arthropathy and tertiary hyperparathyroidism |journal=Australas Radiol |volume=33 |issue=1 |pages=90–2 |year=1989 |pmid=2712794 |doi= |url=}}</ref>
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| [[Category:Musculoskeletal disorders]]
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| ==References== | | ==References== |