Jaundice classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Classification

Neonatal jaundice | Prehepatic jaundice | Hepatic jaundice | Posthepatic jaundice

Jaundice classification

Both conjugated and unconjugated hyperbilirubenemia

Mainly unconjugated hyperbilirubinemia

Billiary obstruction

Intrahepatic cholestasis

Hepatocellular injury

Hepatocellular defects of canalicular excretion or sinusoidal re-uptake

Overproduction

Reduced uptake

Conjugation defect

Acute

Chronic

Acquired

Inherited

For example: • Primary billiary cholangitis • Primary sclerosing cholangitis • Viral hepatitis (ocassionally) • Progressive familial interahepatic cholestasis • Interahepatic cholestasis of pregnancy •Corticosteroids

For example: • Dubin-Johnson • Rotor syndrome

For example: • Hemolysis • Wilson disease • Extravasation • Shunt hyperbilirubinemia

For example: • Portosystemic shunts • Drugs • Gilbert syndrome (some cases)

For example: • Neonatal • Maternal milk • Lucy-Driscoll •Hyperthyroidism • Chronic persitent hepatitis • Advanced cirrhosis

For example: • Crigler-Najjar I • Crigler-Najjar II • Gilbert syndrome

References

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