Chronic cholecystitis pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
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Inflammation of the gallbladder is termed as cholecystitis. Chronic calculous cholecystitis is usually caused by the mechanical obstruction due to gallstones. Chronic acalculous cholecystitis is caused predominantly by the gallbladder stasis. The pathogenesis of chronic cholecystitis involves the following | |||
Gallstones are one of the major causes of cholecystitis. These cause physical obstruction to the lumen of the neck or cystic duct. This results in an increase in the intraluminal pressure. The degree and duration of obstruction are the two main factors that determine its progression.<ref name="pmid22662601">{{cite journal |author=Amr AR, Hamdy HM, Nasr MM, Hedaya MS, Hassan AM |title=Effect of pancreatic biliary reflux as a cofactor in cholecystitis |journal=[[Journal of the Egyptian Society of Parasitology]] |volume=42 |issue=1 |pages=121–8 |year=2012 |month=April |pmid=22662601 |doi= |url= |accessdate=2012-08-20}}</ref><ref name="pmid11483446">{{cite journal |vauthors=Kalloo AN, Kantsevoy SV |title=Gallstones and biliary disease |journal=Prim. Care |volume=28 |issue=3 |pages=591–606, vii |year=2001 |pmid=11483446 |doi= |url=}}</ref><ref name="pmid10750875">{{cite journal |vauthors=Ahmed A, Cheung RC, Keeffe EB |title=Management of gallstones and their complications |journal=Am Fam Physician |volume=61 |issue=6 |pages=1673–80, 1687–8 |year=2000 |pmid=10750875 |doi= |url=}}</ref> | Gallstones are one of the major causes of cholecystitis. These cause physical obstruction to the lumen of the neck or cystic duct. This results in an increase in the intraluminal pressure. The degree and duration of obstruction are the two main factors that determine its progression.<ref name="pmid22662601">{{cite journal |author=Amr AR, Hamdy HM, Nasr MM, Hedaya MS, Hassan AM |title=Effect of pancreatic biliary reflux as a cofactor in cholecystitis |journal=[[Journal of the Egyptian Society of Parasitology]] |volume=42 |issue=1 |pages=121–8 |year=2012 |month=April |pmid=22662601 |doi= |url= |accessdate=2012-08-20}}</ref><ref name="pmid11483446">{{cite journal |vauthors=Kalloo AN, Kantsevoy SV |title=Gallstones and biliary disease |journal=Prim. Care |volume=28 |issue=3 |pages=591–606, vii |year=2001 |pmid=11483446 |doi= |url=}}</ref><ref name="pmid10750875">{{cite journal |vauthors=Ahmed A, Cheung RC, Keeffe EB |title=Management of gallstones and their complications |journal=Am Fam Physician |volume=61 |issue=6 |pages=1673–80, 1687–8 |year=2000 |pmid=10750875 |doi= |url=}}</ref> | ||
Revision as of 17:20, 5 February 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2]
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Overview
Pathophysiology
Pathogenesis
Inflammation of the gallbladder is termed as cholecystitis. Chronic calculous cholecystitis is usually caused by the mechanical obstruction due to gallstones. Chronic acalculous cholecystitis is caused predominantly by the gallbladder stasis. The pathogenesis of chronic cholecystitis involves the following
Gallstones are one of the major causes of cholecystitis. These cause physical obstruction to the lumen of the neck or cystic duct. This results in an increase in the intraluminal pressure. The degree and duration of obstruction are the two main factors that determine its progression.[1][2][3]
- Partial obstruction of short duration may cause biliary colic. Long-term obstruction may progress to chronic cholecystitis.
- Some studies suggest that the pancreatic biliary reflux plays a role in the development of chronic cholecystitis.
Bile Stasis
Bile statis results in acute acalculous cholecystitis but can also lead to chronic acalculous cholecystitis.[4]
- Loss of fluids, opioid drugs, positive pressure ventilation, and other factors cause an increased concentration of bile in the biliary tract.
- Bile contains phosphatidyl choline, which in increased concentrations can cause mucosal disruption.
Pathology
Chornic Cholecystitis
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References
- ↑ Amr AR, Hamdy HM, Nasr MM, Hedaya MS, Hassan AM (2012). "Effect of pancreatic biliary reflux as a cofactor in cholecystitis". Journal of the Egyptian Society of Parasitology. 42 (1): 121–8. PMID 22662601. Unknown parameter
|month=ignored (help);|access-date=requires|url=(help) - ↑ Kalloo AN, Kantsevoy SV (2001). "Gallstones and biliary disease". Prim. Care. 28 (3): 591–606, vii. PMID 11483446.
- ↑ Ahmed A, Cheung RC, Keeffe EB (2000). "Management of gallstones and their complications". Am Fam Physician. 61 (6): 1673–80, 1687–8. PMID 10750875.
- ↑ "Acute acalculous cholecystitis - Surgical Treatment - NCBI Bookshelf". Retrieved 2012-08-20.
- ↑ "Acute cholecystitis - Libre Pathology".