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| ==Laboratory findings== | | ==Laboratory findings== |
| The diagnosis is based on the combination of the symptoms, as very few other diseases cause the same symptoms together. [[Blood test]]s may show elevated [[creatinine]] and [[urea]] levels (in kidney involvement), raised [[IgA]] levels (in about 50%), and raised [[C-reactive protein]] (CRP) or [[erythrocyte sedimentation rate]] (ESR) results; none are specific for Henoch-Schönlein purpura. The [[platelet]] count may be raised, and distinguishes the purpura from diseases in which the low platelets are the cause of the purpura ([[idiopathic thrombocytopenic purpura]], [[thrombotic thrombocytopenic purpura]]).
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| ===Renal disease===
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| Of the 40% of patients who develop kidney involvement, almost all have evidence (visible or on [[urinalysis]]) of blood in the urine. More than half also have [[proteinuria]] (protein in the urine), which in one eighth is severe enough to cause [[nephrotic syndrome]] (generalised swelling due to low protein content of the blood). While abnormalities on urinalysis may continue for a long time, only 1% of all HSP patients develop [[chronic kidney disease]]. [[Hypertension]] (high blood pressure) may occur. Protein loss and high blood pressure, as well as the features on [[biopsy]] of the kidney if performed, may predict progression to advanced kidney disease. Adults are more likely than children to develop advanced kidney disease.<ref name=Shrestha2006>{{cite journal |author=Shrestha S, Sumingan N, Tan J, ''et al'' |title=Henoch Schönlein purpura with nephritis in adults: adverse prognostic indicators in a UK population |journal=QJM |volume=99 |issue=4 |pages=253–65 |year=2006 |pmid=16565522|doi=10.1093/qjmed/hcl034| url=http://qjmed.oxfordjournals.org/cgi/content/full/99/4/253}}</ref>
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| ==References== | | ==References== |