Henoch-Schönlein purpura other diagnostic studies: Difference between revisions

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Revision as of 01:56, 6 February 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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 ==Other Diagnostic Studies==
-===Biopsy===
-If there is doubt about the cause of the skin lesions, a [[biopsy]] of the skin may be performed to distinguish the purpura from other diseases that cause purpura (such as [[vasculitis]] due to [[cryoglobulinemia]]); on microscopy the appearances are of a [[hypersensitivity vasculitis]] and [[immunofluorescence]] demonstrates IgA and [[C3 (complement)|C3]] (a protein of the [[complement system]]) in the blood vessel wall.
-Biopsy of the [[kidney]] may be performed both to establish the diagnosis or to assess the severity of already suspected kidney disease. The main findings on kidney biopsy are increased cells in the [[mesangium]] (part of the [[glomerulus]], where blood is filtered), [[white blood cell]]s, and the development of [[crescentic glomerulonephritis|crescents]]. The changes are indistinguishable from those observed [[IgA nephropathy]].<ref name="Rai1999">{{cite journal |author=Rai A, Nast C, Adler S|title=Henoch-Schönlein purpura nephritis |journal=J. Am. Soc. Nephrol. |volume=10 |issue=12 |pages=2637–44 |year=1999|pmid=10589705 |url=http://jasn.asnjournals.org/cgi/content/full/10/12/2637}}</ref>
 ==References==