Familial adenomatous polyposis (patient information): Difference between revisions
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==Overview== | ==Overview== | ||
Familial adenomatous polyposis (FAP) is an [[inherited]] disorder characterized by [[cancer]] of the [[large intestine]] ([[Colon (anatomy)|colon]]) and [[rectum]]. People with the classic type of familial adenomatous polyposis may begin to develop multiple noncancerous ([[benign]]) growths ([[Polyp|polyps]]) in the [[Colon (anatomy)|colon]] as early as their teenage years. Unless the [[Colon (anatomy)|colon]] is removed, these [[Polyp|polyps]] will become [[malignant]] ([[Cancer|cancerous]]). The average age at which an individual develops [[Colorectal cancer|colon cancer]] in classic familial adenomatous polyposis is 39 years. Some people have a variant of the disorder, called attenuated familial adenomatous polyposis, in which [[polyp]] growth is delayed. The average age of [[colorectal cancer]] onset for attenuated familial adenomatous polyposis is 55 years. | |||
In people with classic familial adenomatous polyposis, the number of [[Polyp|polyps]] increases with age, and hundreds to thousands of [[Polyp|polyps]] can develop in the [[Colon (anatomy)|colon]]. Also of particular significance are noncancerous growths called [[Desmoid tumor|desmoid tumors]]. These fibrous [[Tumor|tumors]] usually occur in the [[Tissue (biology)|tissue]] covering the [[Intestine|intestines]] and may be provoked by [[surgery]] to remove the [[Colon (anatomy)|colon]]. [[Desmoid tumor|Desmoid tumors]] tend to recur after they are surgically removed. In both classic familial adenomatous polyposis and its attenuated variant, benign and malignant tumors are sometimes found in other places in the body, including the [[duodenum]] (a section of the [[small intestine]]), [[stomach]], [[Bone (disambiguation)|bones]], [[skin]], and other [[Tissue (biology)|tissues]]. | |||
==What are the Symptoms of familial adenomatous polyposis?== | ==What are the Symptoms of familial adenomatous polyposis?== | ||
Most familial adenomatous polyposis do not cause symptoms. If you have symptoms, they may include [[blood]] on your underwear or on toilet paper after a [[Defecation|bowel movement]], [[blood]] in your [[Human feces|stool]], or [[constipation]] or [[diarrhea]] lasting more than a week. Patients might have | |||
==What Causes familial adenomatous polyposis?== | ==What Causes familial adenomatous polyposis?== | ||
Mutations in the APC gene and MUTYH gene cause both classic and attenuated familial adenomatous polyposis. These mutations affect the ability of the cell to maintain normal growth and function. Cell overgrowth resulting from mutations leads to the colon polyps seen in familial adenomatous polyposis. | |||
==Who is at Highest Risk?== | ==Who is at Highest Risk?== | ||
Patients with positive family history of colorectal polyps are at highest risk of familial adenomatous polyposis. | |||
==Diagnosis== | ==Diagnosis== | ||
Familial adenomatous polyposis is diagnosed based on clinical presentation, genetic testing, and imagings. | |||
==Treatment Options== | ==Treatment Options== | ||
The best treatment option is to remove [[Colon (anatomy)|large bowel]]. | |||
==Where to find Medical Care for familial adenomatous polyposis?== | ==Where to find Medical Care for familial adenomatous polyposis?== | ||
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==Prevention== | ==Prevention== | ||
[[Genetic counseling]] is used for high risk individuals to prevent familial adenomatous polyposis in families. | |||
==What to Expect (Outlook/Prognosis)?== | ==What to Expect (Outlook/Prognosis)?== | ||
All the patients with familial adenomatous polyposis would develop [[Colorectal cancer|colon cancer]], if left untreated. However, [[prognosis]] is excellent if [[Colon (anatomy)|large bowel]] is removed. | |||
==Possible Complications== | ==Possible Complications== | ||
All the patients with familial adenomatous polyposis would develop [[Colorectal cancer|colon cancer]], if left untreated. | |||
==Sources== | ==Sources== | ||
https://ghr.nlm.nih.gov/condition/familial-adenomatous-polyposis#resources | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Latest revision as of 05:33, 6 February 2018
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Familial Adenomatous Polyposis |
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Where to find medical care for familial adenomatous polyposis? |
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Familial Adenomatous Polyposis On the Web |
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Directions to Hospitals Treating Familial adenomatous polyposis |
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Risk calculators and risk factors for Familial adenomatous polyposis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]
Overview
Familial adenomatous polyposis (FAP) is an inherited disorder characterized by cancer of the large intestine (colon) and rectum. People with the classic type of familial adenomatous polyposis may begin to develop multiple noncancerous (benign) growths (polyps) in the colon as early as their teenage years. Unless the colon is removed, these polyps will become malignant (cancerous). The average age at which an individual develops colon cancer in classic familial adenomatous polyposis is 39 years. Some people have a variant of the disorder, called attenuated familial adenomatous polyposis, in which polyp growth is delayed. The average age of colorectal cancer onset for attenuated familial adenomatous polyposis is 55 years.
In people with classic familial adenomatous polyposis, the number of polyps increases with age, and hundreds to thousands of polyps can develop in the colon. Also of particular significance are noncancerous growths called desmoid tumors. These fibrous tumors usually occur in the tissue covering the intestines and may be provoked by surgery to remove the colon. Desmoid tumors tend to recur after they are surgically removed. In both classic familial adenomatous polyposis and its attenuated variant, benign and malignant tumors are sometimes found in other places in the body, including the duodenum (a section of the small intestine), stomach, bones, skin, and other tissues.
What are the Symptoms of familial adenomatous polyposis?
Most familial adenomatous polyposis do not cause symptoms. If you have symptoms, they may include blood on your underwear or on toilet paper after a bowel movement, blood in your stool, or constipation or diarrhea lasting more than a week. Patients might have
What Causes familial adenomatous polyposis?
Mutations in the APC gene and MUTYH gene cause both classic and attenuated familial adenomatous polyposis. These mutations affect the ability of the cell to maintain normal growth and function. Cell overgrowth resulting from mutations leads to the colon polyps seen in familial adenomatous polyposis.
Who is at Highest Risk?
Patients with positive family history of colorectal polyps are at highest risk of familial adenomatous polyposis.
Diagnosis
Familial adenomatous polyposis is diagnosed based on clinical presentation, genetic testing, and imagings.
Treatment Options
The best treatment option is to remove large bowel.
Where to find Medical Care for familial adenomatous polyposis?
Medical care for familial adenomatous polyposis can be found here.
Prevention
Genetic counseling is used for high risk individuals to prevent familial adenomatous polyposis in families.
What to Expect (Outlook/Prognosis)?
All the patients with familial adenomatous polyposis would develop colon cancer, if left untreated. However, prognosis is excellent if large bowel is removed.
Possible Complications
All the patients with familial adenomatous polyposis would develop colon cancer, if left untreated.
Sources
https://ghr.nlm.nih.gov/condition/familial-adenomatous-polyposis#resources