Jaundice classification: Difference between revisions
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==Overview== | ==Overview== |
Revision as of 20:09, 7 February 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Fatima Shaukat, MD [2]
Overview
Jaundice is classified in two categories: Unconjugated hyperbilirubinemia and combined conjugated and unconjugated hyperbilirubinema. Unconjugated hypebilirubinemia can be caused by eiether increased production, reduced reuptake or defects in conjugation. While combined conjugated and unconjugated hyperbilirubinemia is further classified into: Obstruction of biliary tract, Interahepatic cholestasis, injury to hepatocellular parenchyma and defects of hepatocellular canalicular excretion or re-uptake in sinusoids
Classification
Jaundice classification | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Conjugated and unconjugated hyperbilirubenemia | Unconjugated hyperbilirubinemia | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Obstruction of biliary tract | Intra-hepatic cholestasis | Injury to hepatocellular parenchyma | Defects of hepatocellular canalicular excretion or re-uptake in sinusoids | Increased production | Reduced uptake | Defects in conjugation | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Acute | Chronic | Acquired | Inherited | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
• Primary billiary cholangitis • Primary sclerosing cholangitis • Viral hepatitis (ocassionally) • Progressive familial intrahepatic cholestasis • Intrahepatic Cholestasis of Pregnancy •Corticosteroids | • Dubin-Johnson syndrome • Rotor syndrome | • Hemolysis • Wilson disease • Extravasation • Shunt hyperbilirubinemia | • Portosystemic shunts • Drugs • Gilbert syndrome (some cases) | • Neonatal • Maternal milk • Lucy-Driscoll •Hyperthyroidism • Chronic persitent hepatitis • Advanced cirrhosis | • Crigler-Najjar syndrome l • Crigler-Najjar syndrome II • Gilbert syndrome | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||