Cystic fibrosis classification: Difference between revisions
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==Classification== | ==Classification== | ||
Cystic fibrosis may be classified according to CFTR protein function abnormality: | Cystic fibrosis may be classified according to CFTR protein function abnormality:<ref name="pmid23776378">{{cite journal |vauthors=Burney TJ, Davies JC |title=Gene therapy for the treatment of cystic fibrosis |journal=Appl Clin Genet |volume=5 |issue= |pages=29–36 |year=2012 |pmid=23776378 |pmc=3681190 |doi=10.2147/TACG.S8873 |url=}}</ref> | ||
* '''Class 1:''' A lack of production | * '''Class 1:''' A lack of production | ||
* '''Class 2:''' Failure to reach its site of action due to misfolding (most common defect in Caucasians is Phe508Del) | * '''Class 2:''' Failure to reach its site of action due to misfolding (most common defect in Caucasians is Phe508Del) |
Revision as of 18:26, 8 February 2018
Cystic fibrosis Microchapters |
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Cystic fibrosis classification On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
There is no established system for the classification of [disease name].
OR
[Disease name] may be classified according to [classification method] into [number] subtypes/groups: [group1], [group2], [group3], and [group4].
OR
[Disease name] may be classified into [large number > 6] subtypes based on [classification method 1], [classification method 2], and [classification method 3]. [Disease name] may be classified into several subtypes based on [classification method 1], [classification method 2], and [classification method 3].
OR
Based on the duration of symptoms, [disease name] may be classified as either acute or chronic.
OR
If the staging system involves specific and characteristic findings and features: According to the [staging system + reference], there are [number] stages of [malignancy name] based on the [finding1], [finding2], and [finding3]. Each stage is assigned a [letter/number1] and a [letter/number2] that designate the [feature1] and [feature2].
OR
The staging of [malignancy name] is based on the [staging system].
OR
There is no established system for the staging of [malignancy name].
Classification
Cystic fibrosis may be classified according to CFTR protein function abnormality:[1]
- Class 1: A lack of production
- Class 2: Failure to reach its site of action due to misfolding (most common defect in Caucasians is Phe508Del)
- Class 3: Defects in gating
- Class 4: Conductance
- Class 5: Abnormally low channel numbers
- Class 6: Decreased half-life
References
- ↑ Burney TJ, Davies JC (2012). "Gene therapy for the treatment of cystic fibrosis". Appl Clin Genet. 5: 29–36. doi:10.2147/TACG.S8873. PMC 3681190. PMID 23776378.