Pneumothorax pathophysiology: Difference between revisions
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*Folliculin is found in the connective tissue cells that allow the lungs to contract and expand while breathing. | *Folliculin is found in the connective tissue cells that allow the lungs to contract and expand while breathing. | ||
*It plays a role in repairing the lung tissue after damage. | *It plays a role in repairing the lung tissue after damage. | ||
* | *Altered folliculin protein can trigger the inflammatory process within the lung tissue that can alter and damage the tissue, resulting in blebs formation. | ||
==Genetics== | ==Genetics== | ||
Revision as of 21:45, 9 February 2018
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Pneumothorax Microchapters |
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Treatment |
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Pneumothorax pathophysiology On the Web |
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Risk calculators and risk factors for Pneumothorax pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Feham Tariq, MD [2]
Overview
The exact pathogenesis of [disease name] is not fully understood.
OR
It is thought that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
OR
[Pathogen name] is usually transmitted via the [transmission route] route to the human host.
OR
Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
OR
[Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
OR
The progression to [disease name] usually involves the [molecular pathway].
OR
The pathophysiology of [disease/malignancy] depends on the histological subtype.
Pathophysiology
Pathogenesis
- The pathophysiology of [Pneumothorax] depends on the underlying disease causing it.
Genetic assocaiation
The genetic association of primary sponatneous pneumothorax is as follows:[1][2][3][4][5]
- Primary spontaneous pneumothorax can result as a mutation in the FLCN(folliculin) gene.
- This gene codes for a protein called folliculin.
- It is produced by the cells lining the alveoli of the lung.
- Folliculin is found in the connective tissue cells that allow the lungs to contract and expand while breathing.
- It plays a role in repairing the lung tissue after damage.
- Altered folliculin protein can trigger the inflammatory process within the lung tissue that can alter and damage the tissue, resulting in blebs formation.
Genetics
- [Disease name] is transmitted in [mode of genetic transmission] pattern.
- Genes involved in the pathogenesis of [disease name] include [gene1], [gene2], and [gene3].
- The development of [disease name] is the result of multiple genetic mutations.
Associated Conditions
Gross Pathology
- On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
Microscopic Pathology
- On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
References
- ↑ Chiu HT, Garcia CK (2006). "Familial spontaneous pneumothorax". Curr Opin Pulm Med. 12 (4): 268–72. doi:10.1097/01.mcp.0000230630.73139.f0. PMID 16825879.
- ↑ Bintcliffe O, Maskell N (2014). "Spontaneous pneumothorax". BMJ. 348: g2928. doi:10.1136/bmj.g2928. PMID 24812003.
- ↑ Wakai A (2008). "Spontaneous pneumothorax". BMJ Clin Evid. 2008. PMC 2907964. PMID 19450320.
- ↑ Wakai AP (2011). "Spontaneous pneumothorax". BMJ Clin Evid. 2011. PMC 3275306. PMID 21477390.
- ↑ Andrivet P, Djedaini K, Teboul JL, Brochard L, Dreyfuss D (1995). "Spontaneous pneumothorax. Comparison of thoracic drainage vs immediate or delayed needle aspiration". Chest. 108 (2): 335–9. PMID 7634863.