Pneumothorax pathophysiology: Difference between revisions
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==Genetics== | ==Genetics== | ||
* | ===Genetic assocaiation=== | ||
* | The genetic association of primary sponatneous pneumothorax is as follows:<ref name="pmid16825879">{{cite journal| author=Chiu HT, Garcia CK| title=Familial spontaneous pneumothorax. | journal=Curr Opin Pulm Med | year= 2006 | volume= 12 | issue= 4 | pages= 268-72 | pmid=16825879 | doi=10.1097/01.mcp.0000230630.73139.f0 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16825879 }} </ref><ref name="pmid24812003">{{cite journal| author=Bintcliffe O, Maskell N| title=Spontaneous pneumothorax. | journal=BMJ | year= 2014 | volume= 348 | issue= | pages= g2928 | pmid=24812003 | doi=10.1136/bmj.g2928 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24812003 }} </ref><ref name="pmid19450320">{{cite journal| author=Wakai A| title=Spontaneous pneumothorax. | journal=BMJ Clin Evid | year= 2008 | volume= 2008 | issue= | pages= | pmid=19450320 | doi= | pmc=2907964 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19450320 }} </ref><ref name="pmid21477390">{{cite journal| author=Wakai AP| title=Spontaneous pneumothorax. | journal=BMJ Clin Evid | year= 2011 | volume= 2011 | issue= | pages= | pmid=21477390 | doi= | pmc=3275306 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21477390 }} </ref><ref name="pmid7634863">{{cite journal| author=Andrivet P, Djedaini K, Teboul JL, Brochard L, Dreyfuss D| title=Spontaneous pneumothorax. Comparison of thoracic drainage vs immediate or delayed needle aspiration. | journal=Chest | year= 1995 | volume= 108 | issue= 2 | pages= 335-9 | pmid=7634863 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7634863 }} </ref><ref name="pmid1864347">{{cite journal| author=Lippert HL, Lund O, Blegvad S, Larsen HV| title=Independent risk factors for cumulative recurrence rate after first spontaneous pneumothorax. | journal=Eur Respir J | year= 1991 | volume= 4 | issue= 3 | pages= 324-31 | pmid=1864347 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1864347 }} </ref> | ||
* | *Primary spontaneous pneumothorax can result as a mutation in the FLCN(folliculin) gene. | ||
*This gene codes for a protein called folliculin. | |||
*It is produced by the cells lining the alveoli of the lung. | |||
*Folliculin is found in the connective tissue cells that allow the lungs to contract and expand while breathing. | |||
*It plays a role in repairing the lung tissue after damage. | |||
*Altered folliculin protein can trigger the inflammatory process within the lung tissue that can alter and damage the tissue, resulting in blebs formation. | |||
==Associated Conditions== | ==Associated Conditions== | ||
Revision as of 15:11, 12 February 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Feham Tariq, MD [2]
Overview
The exact pathogenesis of [disease name] is not fully understood.
OR
It is thought that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
OR
[Pathogen name] is usually transmitted via the [transmission route] route to the human host.
OR
Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
OR
[Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
OR
The progression to [disease name] usually involves the [molecular pathway].
OR
The pathophysiology of [disease/malignancy] depends on the histological subtype.
Pathophysiology
Pathogenesis
- The pathophysiology of pneumothorax depends on the underlying disease causing it.
Genetics
Genetic assocaiation
The genetic association of primary sponatneous pneumothorax is as follows:[1][2][3][4][5][6]
- Primary spontaneous pneumothorax can result as a mutation in the FLCN(folliculin) gene.
- This gene codes for a protein called folliculin.
- It is produced by the cells lining the alveoli of the lung.
- Folliculin is found in the connective tissue cells that allow the lungs to contract and expand while breathing.
- It plays a role in repairing the lung tissue after damage.
- Altered folliculin protein can trigger the inflammatory process within the lung tissue that can alter and damage the tissue, resulting in blebs formation.
Associated Conditions
Gross Pathology
- On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
Microscopic Pathology
- On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
References
- ↑ Chiu HT, Garcia CK (2006). "Familial spontaneous pneumothorax". Curr Opin Pulm Med. 12 (4): 268–72. doi:10.1097/01.mcp.0000230630.73139.f0. PMID 16825879.
- ↑ Bintcliffe O, Maskell N (2014). "Spontaneous pneumothorax". BMJ. 348: g2928. doi:10.1136/bmj.g2928. PMID 24812003.
- ↑ Wakai A (2008). "Spontaneous pneumothorax". BMJ Clin Evid. 2008. PMC 2907964. PMID 19450320.
- ↑ Wakai AP (2011). "Spontaneous pneumothorax". BMJ Clin Evid. 2011. PMC 3275306. PMID 21477390.
- ↑ Andrivet P, Djedaini K, Teboul JL, Brochard L, Dreyfuss D (1995). "Spontaneous pneumothorax. Comparison of thoracic drainage vs immediate or delayed needle aspiration". Chest. 108 (2): 335–9. PMID 7634863.
- ↑ Lippert HL, Lund O, Blegvad S, Larsen HV (1991). "Independent risk factors for cumulative recurrence rate after first spontaneous pneumothorax". Eur Respir J. 4 (3): 324–31. PMID 1864347.