Occupational lung disease laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
There are no diagnostic laboratory findings associated with occupational lung disease. However, useful laboratory findings consistent with the diagnosis of occupational lung disease include abnormal arterial blood gases, sputum analysis, and blood picture. | There are no diagnostic laboratory findings associated with occupational lung disease. However, useful laboratory findings consistent with the diagnosis of occupational lung disease include abnormal [[Arterial blood gas|arterial blood gases]], [[sputum]] analysis, and blood picture. | ||
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*Laboratory findings consistent with the diagnosis of occupational lung disease include:<ref name="pmid16545629">{{cite journal |vauthors=du Bois RM |title=Evolving concepts in the early and accurate diagnosis of idiopathic pulmonary fibrosis |journal=Clin. Chest Med. |volume=27 |issue=1 Suppl 1 |pages=S17–25, v–vi |year=2006 |pmid=16545629 |doi=10.1016/j.ccm.2005.08.001 |url=}}</ref><ref name="pmid9563720">{{cite journal |vauthors=Gay SE, Kazerooni EA, Toews GB, Lynch JP, Gross BH, Cascade PN, Spizarny DL, Flint A, Schork MA, Whyte RI, Popovich J, Hyzy R, Martinez FJ |title=Idiopathic pulmonary fibrosis: predicting response to therapy and survival |journal=Am. J. Respir. Crit. Care Med. |volume=157 |issue=4 Pt 1 |pages=1063–72 |year=1998 |pmid=9563720 |doi=10.1164/ajrccm.157.4.9703022 |url=}}</ref><ref name="pmid21996929">{{cite journal |vauthors=Neghab M, Mohraz MH, Hassanzadeh J |title=Symptoms of respiratory disease and lung functional impairment associated with occupational inhalation exposure to carbon black dust |journal=J Occup Health |volume=53 |issue=6 |pages=432–8 |year=2011 |pmid=21996929 |doi= |url=}}</ref> | *Laboratory findings consistent with the diagnosis of occupational lung disease include:<ref name="pmid16545629">{{cite journal |vauthors=du Bois RM |title=Evolving concepts in the early and accurate diagnosis of idiopathic pulmonary fibrosis |journal=Clin. Chest Med. |volume=27 |issue=1 Suppl 1 |pages=S17–25, v–vi |year=2006 |pmid=16545629 |doi=10.1016/j.ccm.2005.08.001 |url=}}</ref><ref name="pmid9563720">{{cite journal |vauthors=Gay SE, Kazerooni EA, Toews GB, Lynch JP, Gross BH, Cascade PN, Spizarny DL, Flint A, Schork MA, Whyte RI, Popovich J, Hyzy R, Martinez FJ |title=Idiopathic pulmonary fibrosis: predicting response to therapy and survival |journal=Am. J. Respir. Crit. Care Med. |volume=157 |issue=4 Pt 1 |pages=1063–72 |year=1998 |pmid=9563720 |doi=10.1164/ajrccm.157.4.9703022 |url=}}</ref><ref name="pmid21996929">{{cite journal |vauthors=Neghab M, Mohraz MH, Hassanzadeh J |title=Symptoms of respiratory disease and lung functional impairment associated with occupational inhalation exposure to carbon black dust |journal=J Occup Health |volume=53 |issue=6 |pages=432–8 |year=2011 |pmid=21996929 |doi= |url=}}</ref> | ||
**Abnormal ABG | **Abnormal [[Arterial blood gas|ABG]] | ||
***May indicate hypoxia, hypercapnia and respiratory acidosis | ***May indicate [[hypoxia]], [[hypercapnia]] and [[respiratory acidosis]] | ||
**Abnormal sputum analysis | **Abnormal [[sputum]] analysis | ||
***May contain bacteria, such as mycobacterium tuberculosis or inorganic particles, such as asbestos bodies or organic particles | ***May contain [[bacteria]], such as [[mycobacterium tuberculosis]] or inorganic particles, such as asbestos bodies or organic particles | ||
**Peak flow assessment | **[[Peak flow meter|Peak flow]] assessment | ||
***May be below normal range which is 100 liters/minute for men, and 80 liters/minute for women | ***May be below normal range which is 100 liters/minute for men, and 80 liters/minute for women | ||
**Spirometry | **[[Spirometry]] | ||
***May indicate an obstructive or restrictive pulmonary disease | ***May indicate an [[Obstructive airway diseases|obstructive]] or [[Restrictive Lung Disease|restrictive]] pulmonary disease | ||
***A FEV1/FVC ratio < 80% indicates and obstructive disease,such as asthma, whilst a FEV1/FVC ratio higher than restrictive pulmonary disease indicates a restrictive disease, such as pulmonary fibrosis | ***A [[FEV1/FVC ratio]] < 80% indicates and [[Obstructive airway diseases|obstructive]] disease,such as asthma, whilst a [[FEV1/FVC ratio]] higher than [[Restrictive lung disease|restrictive]] pulmonary disease indicates a restrictive disease, such as [[pulmonary fibrosis]] | ||
**CBC | **[[Complete blood count|CBC]] | ||
***May indicate anemia, neutrophilia, elevated ESR, elevated CRP, and elevated immunoglobulin | ***May indicate [[anemia]], [[neutrophilia]], elevated [[Erythrocyte sedimentation rate|ESR]], elevated [[C-reactive protein|CRP]], and elevated [[Antibody|immunoglobulin]] | ||
**Bronchoscopy and bronchoalveolar lavage | **[[Bronchoscopy]] and [[bronchoalveolar lavage]] | ||
***May reveal mineral dust | ***May reveal mineral dust | ||
**Tuberculin skin test | **[[Tuberculin skin test]] | ||
***To test for tuberculosis, and induration > 5mm is positive | ***To test for [[tuberculosis]], and induration > 5mm is positive | ||
**Stool examination for occult blood | **Stool examination for [[occult blood]] | ||
***May indicate colorectal carcinoma | ***May indicate [[Colorectal cancer|colorectal carcinoma]] | ||
==References== | ==References== | ||
Revision as of 20:05, 15 February 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Hadeel Maksoud M.D.[2]
Overview
There are no diagnostic laboratory findings associated with occupational lung disease. However, useful laboratory findings consistent with the diagnosis of occupational lung disease include abnormal arterial blood gases, sputum analysis, and blood picture.
Laboratory Findings
- Laboratory findings consistent with the diagnosis of occupational lung disease include:[1][2][3]
- Abnormal ABG
- May indicate hypoxia, hypercapnia and respiratory acidosis
- Abnormal sputum analysis
- May contain bacteria, such as mycobacterium tuberculosis or inorganic particles, such as asbestos bodies or organic particles
- Peak flow assessment
- May be below normal range which is 100 liters/minute for men, and 80 liters/minute for women
- Spirometry
- May indicate an obstructive or restrictive pulmonary disease
- A FEV1/FVC ratio < 80% indicates and obstructive disease,such as asthma, whilst a FEV1/FVC ratio higher than restrictive pulmonary disease indicates a restrictive disease, such as pulmonary fibrosis
- CBC
- May indicate anemia, neutrophilia, elevated ESR, elevated CRP, and elevated immunoglobulin
- Bronchoscopy and bronchoalveolar lavage
- May reveal mineral dust
- Tuberculin skin test
- To test for tuberculosis, and induration > 5mm is positive
- Stool examination for occult blood
- May indicate colorectal carcinoma
- Abnormal ABG
References
- ↑ du Bois RM (2006). "Evolving concepts in the early and accurate diagnosis of idiopathic pulmonary fibrosis". Clin. Chest Med. 27 (1 Suppl 1): S17–25, v–vi. doi:10.1016/j.ccm.2005.08.001. PMID 16545629.
- ↑ Gay SE, Kazerooni EA, Toews GB, Lynch JP, Gross BH, Cascade PN, Spizarny DL, Flint A, Schork MA, Whyte RI, Popovich J, Hyzy R, Martinez FJ (1998). "Idiopathic pulmonary fibrosis: predicting response to therapy and survival". Am. J. Respir. Crit. Care Med. 157 (4 Pt 1): 1063–72. doi:10.1164/ajrccm.157.4.9703022. PMID 9563720.
- ↑ Neghab M, Mohraz MH, Hassanzadeh J (2011). "Symptoms of respiratory disease and lung functional impairment associated with occupational inhalation exposure to carbon black dust". J Occup Health. 53 (6): 432–8. PMID 21996929.