Thrombotic thrombocytopenic purpura history and symptoms: Difference between revisions

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Revision as of 20:55, 20 February 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

History and Symptoms

References

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 ==Overview==
 ==History and Symptoms==
-Classically, the following five symptoms are indicative of this elusive disease.  The full 'pentad' is not seen in all cases and clinical suspicion and acumen are the foremost necessity.
-* Fluctuating [[neurology|neurological]] symptoms, such as bizarre behavior, altered mental status, [[stroke]] or [[headache]]s (65%);
-* [[Acute renal failure|Kidney failure]] (46%);
-* [[Fever]] (33%);
-* [[Thrombocytopenia]] (low [[platelet]] count; most < 50,000), leading to [[bruising]] or [[purpura]];
-* [[Microangiopathic hemolytic anemia]] ([[anemia]], [[jaundice]], elevated LDH and a characteristic  [[blood film]] showing schistocytes or fragmented erythrocytes).
-A patient may notice dark urine from the hemolytic anemia.  Because of the many small areas of ischemia produced by clots in the microvasculature, symptoms may be diffuse and fluctuating, including the classical bruising, confusion, or headache, but also nausea and vomiting (from ischemia in the GI tract or from central nervous system involvement), chest pain from cardiac ischemia, seizures, muscle and joint pain, etc.
 ==References==
 {{reflist|2}}

Thrombotic thrombocytopenic purpura history and symptoms: Difference between revisions

Revision as of 20:55, 20 February 2018

Overview

History and Symptoms

References

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