Jaundice classification: Difference between revisions
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==Classification== | ==Classification== | ||
{{family tree/start}} | Jaundice is classified into two subtypes:<ref name="pmid28145671">{{cite journal| author=Fargo MV, Grogan SP, Saguil A| title=Evaluation of Jaundice in Adults. | journal=Am Fam Physician | year= 2017 | volume= 95 | issue= 3 | pages= 164-168 | pmid=28145671 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28145671 }}</ref><ref name="pmid256472092">{{cite journal| author=VanWagner LB, Green RM| title=Evaluating elevated bilirubin levels in asymptomatic adults. | journal=JAMA | year= 2015 | volume= 313 | issue= 5 | pages= 516-7 | pmid=25647209 | doi=10.1001/jama.2014.12835 | pmc=4424929 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25647209 }}</ref><ref name="pmid29187150">{{cite journal| author=Gadia CLB, Manirakiza A, Tekpa G, Konamna X, Vickos U, Nakoune E| title=Identification of pathogens for differential diagnosis of fever with jaundice in the Central African Republic: a retrospective assessment, 2008-2010. | journal=BMC Infect Dis | year= 2017 | volume= 17 | issue= 1 | pages= 735 | pmid=29187150 | doi=10.1186/s12879-017-2840-8 | pmc=5707826 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29187150 }}</ref> | ||
*Conjugated hyperbilirubinemia<ref name="pmid291871502">{{cite journal| author=Gadia CLB, Manirakiza A, Tekpa G, Konamna X, Vickos U, Nakoune E| title=Identification of pathogens for differential diagnosis of fever with jaundice in the Central African Republic: a retrospective assessment, 2008-2010. | journal=BMC Infect Dis | year= 2017 | volume= 17 | issue= 1 | pages= 735 | pmid=29187150 | doi=10.1186/s12879-017-2840-8 | pmc=5707826 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29187150 }}</ref> | |||
*Conjugated and unconjugated hyperbilirubinemia<ref name="pmid12198827">{{cite journal| author=Drenth JP, Peters WH, Jansen JB| title=[From gene to disease; unconjugated hyperbilirubinemia: Gilbert's syndrome and Crigler-Najjar types I and II]. | journal=Ned Tijdschr Geneeskd | year= 2002 | volume= 146 | issue= 32 | pages= 1488-90 | pmid=12198827 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12198827 }}</ref>{{family tree/start}} | |||
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Revision as of 22:05, 20 February 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Fatima Shaukat, MD [2]
Overview
Jaundice is classified in two categories: Unconjugated hyperbilirubinemia and combined conjugated and unconjugated hyperbilirubinema. Unconjugated hypebilirubinemia can be caused by eiether increased production, reduced reuptake or defects in conjugation. While combined conjugated and unconjugated hyperbilirubinemia is further classified into: Obstruction of biliary tract, Interahepatic cholestasis, injury to hepatocellular parenchyma and defects of hepatocellular canalicular excretion or re-uptake in sinusoids
Classification
Jaundice is classified into two subtypes:[1][2][3]
- Conjugated hyperbilirubinemia[4]
- Conjugated and unconjugated hyperbilirubinemia[5]
Jaundice classification Conjugated and unconjugated hyperbilirubenemia Unconjugated hyperbilirubinemia Obstruction of biliary tract Intra-hepatic cholestasis Injury to hepatocellular parenchyma Defects of hepatocellular canalicular excretion or re-uptake in sinusoids Increased production Reduced uptake Defects in conjugation Acute Chronic Acquired Inherited • Primary billiary cholangitis
• Primary sclerosing cholangitis
• Viral hepatitis (ocassionally)
• Progressive familial intrahepatic cholestasis
• Intrahepatic Cholestasis of Pregnancy
•Corticosteroids• Dubin-Johnson syndrome
• Rotor syndrome
• Hemolysis
• Wilson disease
• Extravasation
• Shunt hyperbilirubinemia• Portosystemic shunts
• Drugs
• Gilbert syndrome (some cases)
• Neonatal
• Maternal milk
• Lucy-Driscoll
•Hyperthyroidism
• Chronic persitent hepatitis
• Advanced cirrhosis• Crigler-Najjar syndrome l
• Crigler-Najjar syndrome II
• Gilbert syndromeReferences
- ↑ Fargo MV, Grogan SP, Saguil A (2017). "Evaluation of Jaundice in Adults". Am Fam Physician. 95 (3): 164–168. PMID 28145671.
- ↑ VanWagner LB, Green RM (2015). "Evaluating elevated bilirubin levels in asymptomatic adults". JAMA. 313 (5): 516–7. doi:10.1001/jama.2014.12835. PMC 4424929. PMID 25647209.
- ↑ Gadia CLB, Manirakiza A, Tekpa G, Konamna X, Vickos U, Nakoune E (2017). "Identification of pathogens for differential diagnosis of fever with jaundice in the Central African Republic: a retrospective assessment, 2008-2010". BMC Infect Dis. 17 (1): 735. doi:10.1186/s12879-017-2840-8. PMC 5707826. PMID 29187150.
- ↑ Gadia CLB, Manirakiza A, Tekpa G, Konamna X, Vickos U, Nakoune E (2017). "Identification of pathogens for differential diagnosis of fever with jaundice in the Central African Republic: a retrospective assessment, 2008-2010". BMC Infect Dis. 17 (1): 735. doi:10.1186/s12879-017-2840-8. PMC 5707826. PMID 29187150.
- ↑ Drenth JP, Peters WH, Jansen JB (2002). "[From gene to disease; unconjugated hyperbilirubinemia: Gilbert's syndrome and Crigler-Najjar types I and II]". Ned Tijdschr Geneeskd. 146 (32): 1488–90. PMID 12198827.