Adenocarcinoma of the lung causes: Difference between revisions
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{{CMG}}; {{AE}} {{SC}} | {{CMG}}; {{AE}} {{SC}} | ||
==Overview== | ==Overview== | ||
Genetic mutations are primarily responsible for the development of adenocarcinoma of the lung. Genetic mutations of [[epidermal growth factor receptor|EGFR]] (7p11), [[KRAS]] (12p12), [[BRAF]] (7q34), and PIK3CA (3q26) play a major role in the pathogenesis of adenocarcinoma. | [[Mutation|Genetic mutations]] are primarily responsible for the development of adenocarcinoma of the lung. [[Mutation|Genetic mutations]] of [[epidermal growth factor receptor|EGFR]] (7p11), [[KRAS]] (12p12), [[BRAF]] (7q34), and PIK3CA (3q26) play a major role in the pathogenesis of adenocarcinoma. | ||
==Causes== | ==Causes== | ||
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:* PIK3CA (3q26) | :* PIK3CA (3q26) | ||
:* ERBB2 (17q12) | :* ERBB2 (17q12) | ||
:* Translocation EML4/[[anaplastic lymphoma kinase|ALK]] | :* [[Chromosomal translocation|Translocation]] EML4/[[anaplastic lymphoma kinase|ALK]] | ||
:* Tyrosine kinase fusions | :* [[Tyrosine kinase|Tyrosine kinase fusions]] | ||
:* [[ALK]] (2p23), [[ROS1 (gene)|ROS1]] (6q22), and [[RET proto-oncogene|RET]] (10q11) | :* [[ALK]] (2p23), [[ROS1 (gene)|ROS1]] (6q22), and [[RET proto-oncogene|RET]] (10q11) | ||
Latest revision as of 14:58, 6 March 2018
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Adenocarcinoma of the Lung Microchapters |
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Differentiating Adenocarcinoma of the Lung from other Diseases |
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Adenocarcinoma of the lung causes On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]
Overview
Genetic mutations are primarily responsible for the development of adenocarcinoma of the lung. Genetic mutations of EGFR (7p11), KRAS (12p12), BRAF (7q34), and PIK3CA (3q26) play a major role in the pathogenesis of adenocarcinoma.
Causes
- EGFR (7p11)
- KRAS (12p12)
- BRAF (7q34)
- PIK3CA (3q26)
- ERBB2 (17q12)
- Translocation EML4/ALK
- Tyrosine kinase fusions
- ALK (2p23), ROS1 (6q22), and RET (10q11)
References
- ↑ Stewart, Bernard (2014). World cancer report 2014. Lyon, France Geneva, Switzerland: International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization. ISBN 9283204298.
- ↑ Stewart, Bernard (2014). World cancer report 2014. Lyon, France Geneva, Switzerland: International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization. ISBN 9283204298.
- ↑ Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S; et al. (2007). "Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer". Nature. 448 (7153): 561–6. doi:10.1038/nature05945. PMID 17625570.
- ↑ Davies KD, Le AT, Theodoro MF, Skokan MC, Aisner DL, Berge EM; et al. (2012). "Identifying and targeting ROS1 gene fusions in non-small cell lung cancer". Clin Cancer Res. 18 (17): 4570–9. doi:10.1158/1078-0432.CCR-12-0550. PMC 3703205. PMID 22919003.