Altitude sickness pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
Abbreviations: CBV= Cerebral blood volume, CBF= Cerebral or coronary blood flow, Pcap= Pulmonary capillary pressure, HACE= High-altitude cerebral edema, HAPE= High-altitude pulmonary edema | Abbreviations: CBV= Cerebral blood volume, CBF= Cerebral or coronary blood flow, Pcap= Pulmonary capillary pressure, HACE= High-altitude cerebral edema, HAPE= High-altitude pulmonary edema <ref name="pmid20417340">{{cite journal |vauthors=Imray C, Wright A, Subudhi A, Roach R |title=Acute mountain sickness: pathophysiology, prevention, and treatment |journal=Prog Cardiovasc Dis |volume=52 |issue=6 |pages=467–84 |date=2010 |pmid=20417340 |doi=10.1016/j.pcad.2010.02.003 |url=}}</ref><ref name="pmid23908794">{{cite journal |vauthors=Taylor AT |title=High-altitude illnesses: physiology, risk factors, prevention, and treatment |journal=Rambam Maimonides Med J |volume=2 |issue=1 |pages=e0022 |date=January 2011 |pmid=23908794 |pmc=3678789 |doi=10.5041/RMMJ.10022 |url=}}</ref><ref name="pmid10634991">{{cite journal |vauthors=Hackett PH |title=High altitude cerebral edema and acute mountain sickness. A pathophysiology update |journal=Adv. Exp. Med. Biol. |volume=474 |issue= |pages=23–45 |date=1999 |pmid=10634991 |doi= |url=}}</ref><ref name="pmid21718562">{{cite journal |vauthors=Murdoch D |title=Altitude sickness |journal=BMJ Clin Evid |volume=2010 |issue= |pages= |date=March 2010 |pmid=21718562 |pmc=2907615 |doi= |url=}}</ref> | ||
Revision as of 18:38, 15 March 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]
Overview
Pathophysiology
Abbreviations: CBV= Cerebral blood volume, CBF= Cerebral or coronary blood flow, Pcap= Pulmonary capillary pressure, HACE= High-altitude cerebral edema, HAPE= High-altitude pulmonary edema [1][2][3][4]
| Altitude hypoxemia | |||||||||||||||||||||||||||||||||||
| Brain | Lung | ||||||||||||||||||||||||||||||||||
| Vasodilation | Uneven vasoconstriction | ||||||||||||||||||||||||||||||||||
| ↑CBV | ↑CBF | ↑PAP | |||||||||||||||||||||||||||||||||
| Overperfusion | Focal/regional overperfusion | ||||||||||||||||||||||||||||||||||
| ↑Pcap | ↑Pcap | ||||||||||||||||||||||||||||||||||
| Vasogenic edema | Capillary leak | ||||||||||||||||||||||||||||||||||
| HACE | HAPE | ||||||||||||||||||||||||||||||||||
References
- ↑ Imray C, Wright A, Subudhi A, Roach R (2010). "Acute mountain sickness: pathophysiology, prevention, and treatment". Prog Cardiovasc Dis. 52 (6): 467–84. doi:10.1016/j.pcad.2010.02.003. PMID 20417340.
- ↑ Taylor AT (January 2011). "High-altitude illnesses: physiology, risk factors, prevention, and treatment". Rambam Maimonides Med J. 2 (1): e0022. doi:10.5041/RMMJ.10022. PMC 3678789. PMID 23908794.
- ↑ Hackett PH (1999). "High altitude cerebral edema and acute mountain sickness. A pathophysiology update". Adv. Exp. Med. Biol. 474: 23–45. PMID 10634991.
- ↑ Murdoch D (March 2010). "Altitude sickness". BMJ Clin Evid. 2010. PMC 2907615. PMID 21718562.