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{{Autoimmune hemolytic anemia}} | {{Autoimmune hemolytic anemia}} | ||
{{CMG}} '''Assosciate Editor(s)-In-Chief:''' [[User: Prashanthsaddala|Prashanth Saddala M.B.B.S]] | {{CMG}} '''Assosciate Editor(s)-In-Chief:''' [[User: Prashanthsaddala|Prashanth Saddala M.B.B.S]]; {{shyam}} | ||
==Overview== | ==Overview== | ||
==Historical Perspective== | ==Historical Perspective== | ||
*In '''1973''', Playfair and Marshall-Clarke developed a murine model of autoimmune hemolytic anemia. In this murine model, the mice developed autoantibodies against their own [[red blood cells]] upon injection of rat [[red blood cells]]. The rat [[red blood cells]] triggered antibody production, since the rat antigens were foreign, but the antibodies also reacted against self antigens (murine antigens) also <ref name="pmid15637139">{{cite journal| author=Mqadmi A, Zheng X, Yazdanbakhsh K| title=CD4+CD25+ regulatory T cells control induction of autoimmune hemolytic anemia. | journal=Blood | year= 2005 | volume= 105 | issue= 9 | pages= 3746-8 | pmid=15637139 | doi=10.1182/blood-2004-12-4692 | pmc=1895013 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15637139 }} </ref> Clinically, the mice developed anemia, elevated reticulocyte count, and positive [[direct antiglobulin test]] ([[Coomb's test]]). The mice had decreased survival.<ref name="pmid15637139">{{cite journal| author=Mqadmi A, Zheng X, Yazdanbakhsh K| title=CD4+CD25+ regulatory T cells control induction of autoimmune hemolytic anemia. | journal=Blood | year= 2005 | volume= 105 | issue= 9 | pages= 3746-8 | pmid=15637139 | doi=10.1182/blood-2004-12-4692 | pmc=1895013 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15637139 }} </ref> | |||
==References== | ==References== | ||
Revision as of 22:20, 16 March 2018
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Autoimmune hemolytic anemia Microchapters |
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Differentiating Autoimmune hemolytic anemia from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Assosciate Editor(s)-In-Chief: Prashanth Saddala M.B.B.S; Shyam Patel [2]
Overview
Historical Perspective
- In 1973, Playfair and Marshall-Clarke developed a murine model of autoimmune hemolytic anemia. In this murine model, the mice developed autoantibodies against their own red blood cells upon injection of rat red blood cells. The rat red blood cells triggered antibody production, since the rat antigens were foreign, but the antibodies also reacted against self antigens (murine antigens) also [1] Clinically, the mice developed anemia, elevated reticulocyte count, and positive direct antiglobulin test (Coomb's test). The mice had decreased survival.[1]
References
- ↑ 1.0 1.1 Mqadmi A, Zheng X, Yazdanbakhsh K (2005). "CD4+CD25+ regulatory T cells control induction of autoimmune hemolytic anemia". Blood. 105 (9): 3746–8. doi:10.1182/blood-2004-12-4692. PMC 1895013. PMID 15637139.