Mesothelioma laboratory tests: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
===Pleural Fluid Analysis=== | ===Pleural Fluid Analysis=== | ||
*Pleural fluid analysis, via [[thoracentesis]], may be performed to help in the diagnosis of pleural mesothelioma. | *Pleural fluid analysis, via [[thoracentesis]], may be performed to help in the diagnosis of pleural mesothelioma.<ref name="pmid1914546">{{cite journal| author=Gottehrer A, Taryle DA, Reed CE, Sahn SA| title=Pleural fluid analysis in malignant mesothelioma. Prognostic implications. | journal=Chest | year= 1991 | volume= 100 | issue= 4 | pages= 1003-6 | pmid=1914546 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1914546 }} </ref> | ||
*Pleural mesothelioma is associated with decreased pleural pH (< 7.30) and decreased pleural fluid/serum glucose ratios. | *Pleural mesothelioma is associated with decreased pleural pH (< 7.30) and decreased pleural fluid/serum glucose ratios. | ||
*Pleural fluid cytology may or may not be positive for mesothelioma.<ref name="pmid24920946">{{cite journal| author=Na MJ| title=Diagnostic tools of pleural effusion. | journal=Tuberc Respir Dis (Seoul) | year= 2014 | volume= 76 | issue= 5 | pages= 199-210 | pmid=24920946 | doi=10.4046/trd.2014.76.5.199 | pmc=PMC4050067 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24920946 }} </ref> | *Pleural fluid cytology may or may not be positive for mesothelioma.<ref name="pmid24920946">{{cite journal| author=Na MJ| title=Diagnostic tools of pleural effusion. | journal=Tuberc Respir Dis (Seoul) | year= 2014 | volume= 76 | issue= 5 | pages= 199-210 | pmid=24920946 | doi=10.4046/trd.2014.76.5.199 | pmc=PMC4050067 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24920946 }} </ref> | ||
===Serum Biomarker=== | |||
===Fluorescence In Situ Hybridization (FISH)=== | ===Fluorescence In Situ Hybridization (FISH)=== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Laboratory findings consistent with the diagnosis of mesothelioma include abnormal pleural fluid analysis (decreased pleural pH and pleural fluid/serum glucose ratio).The presence of serum biomarker megakaryocyte potentiating factor (MPF) is suggestive of malignant mesothelioma.
Laboratory Findings
Pleural Fluid Analysis
- Pleural fluid analysis, via thoracentesis, may be performed to help in the diagnosis of pleural mesothelioma.[1]
- Pleural mesothelioma is associated with decreased pleural pH (< 7.30) and decreased pleural fluid/serum glucose ratios.
- Pleural fluid cytology may or may not be positive for mesothelioma.[2]
Serum Biomarker
Fluorescence In Situ Hybridization (FISH)
- FISH may be helpful in the diagnosis of mesothelioma. It helps in distinguishing malignant mesothelioma from reactive mesothelial cells in effusions.[3]
- Mutlitarget FISH assay may be used to detect chromosomal abberations (chromosomes 3, 7, 17, and 9p21).
- FISH technique may also be used to explore the alternative mechanism of tumor suppressor gene inactivation by methylation of p16, p14, and p15 gene in the pathogenesis of mesothelioma.[3]
References
- ↑ Gottehrer A, Taryle DA, Reed CE, Sahn SA (1991). "Pleural fluid analysis in malignant mesothelioma. Prognostic implications". Chest. 100 (4): 1003–6. PMID 1914546.
- ↑ Na MJ (2014). "Diagnostic tools of pleural effusion". Tuberc Respir Dis (Seoul). 76 (5): 199–210. doi:10.4046/trd.2014.76.5.199. PMC 4050067. PMID 24920946.
- ↑ 3.0 3.1 Savic S, Franco N, Grilli B, Barascud Ade V, Herzog M, Bode B; et al. (2010). "Fluorescence in situ hybridization in the definitive diagnosis of malignant mesothelioma in effusion cytology". Chest. 138 (1): 137–44. doi:10.1378/chest.09-1951. PMID 20139227.