Down syndrome epidemiology and demographics: Difference between revisions
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=== Prevalence === | === Prevalence === | ||
* Down syndrome is the most common chromosomal abnormality. | * Down syndrome is the most common chromosomal abnormality. | ||
* Almost 10,000 children are born with Down syndrome in the United States each year (one in 691 live births; prevalence of 100.3 per 100,000) | * Almost 10,000 children are born with Down syndrome in the United States each year (one in 691 live births; prevalence of 100.3 per 100,000)<ref name="pmid17910090">{{cite journal |vauthors=Sherman SL, Allen EG, Bean LH, Freeman SB |title=Epidemiology of Down syndrome |journal=Ment Retard Dev Disabil Res Rev |volume=13 |issue=3 |pages=221–7 |date=2007 |pmid=17910090 |doi=10.1002/mrdd.20157 |url=}}</ref> | ||
=== Incidence === | === Incidence === | ||
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[[Maternal age effect|Maternal age]] influences the chances of conceiving a baby with Down syndrome. At maternal age 20 to 24, the probability is 1/1490; at age 40 the probability is 1/60, and at age 49 the probability is 1/11.<ref name="Hook">{{cite journal|author = Hook, E.B.|year = 1981|title = Rates of chromosomal abnormalities at different maternal ages|journal = Obstet Gynecol|volume = 58|pages = 282}} PMID 6455611</ref> Although the probability increases with maternal age, 80% of children with Down syndrome are born to women under the age of 35,<ref>Estimate from {{cite web |title=National Down Syndrome Center |url=http://www.ndsccenter.org/resources/package3.php |accessdate = 2006-04-21}}</ref> reflecting the overall fertility of that age group. Recent data also suggest that paternal age also increases the risk of Down Syndrome manifesting in pregnancies in older mothers.<ref>Warner, Jennifer. "Dad's Age Raises Down Syndrome Risk, Too", {{cite web |title=WebMD Medical News |url=http://www.webmd.com/infertility-and-reproduction/news/20030701/dad-age-down-syndrome |accessdate= 2007-09-29}}</ref> | [[Maternal age effect|Maternal age]] influences the chances of conceiving a baby with Down syndrome. At maternal age 20 to 24, the probability is 1/1490; at age 40 the probability is 1/60, and at age 49 the probability is 1/11.<ref name="Hook">{{cite journal|author = Hook, E.B.|year = 1981|title = Rates of chromosomal abnormalities at different maternal ages|journal = Obstet Gynecol|volume = 58|pages = 282}} PMID 6455611</ref> Although the probability increases with maternal age, 80% of children with Down syndrome are born to women under the age of 35,<ref>Estimate from {{cite web |title=National Down Syndrome Center |url=http://www.ndsccenter.org/resources/package3.php |accessdate = 2006-04-21}}</ref> reflecting the overall fertility of that age group. Recent data also suggest that paternal age also increases the risk of Down Syndrome manifesting in pregnancies in older mothers.<ref>Warner, Jennifer. "Dad's Age Raises Down Syndrome Risk, Too", {{cite web |title=WebMD Medical News |url=http://www.webmd.com/infertility-and-reproduction/news/20030701/dad-age-down-syndrome |accessdate= 2007-09-29}}</ref> | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Epidemiology and Demographics
Prevalence
- Down syndrome is the most common chromosomal abnormality.
- Almost 10,000 children are born with Down syndrome in the United States each year (one in 691 live births; prevalence of 100.3 per 100,000)[1]
Incidence
Maternal age
- Birth rates are highest among mothers of advanced maternal age however 80% of all children with Down syndrome are born to mothers younger than 35 years.
Race
Gender
Geographic distribution
Maternal age influences the chances of conceiving a baby with Down syndrome. At maternal age 20 to 24, the probability is 1/1490; at age 40 the probability is 1/60, and at age 49 the probability is 1/11.[2] Although the probability increases with maternal age, 80% of children with Down syndrome are born to women under the age of 35,[3] reflecting the overall fertility of that age group. Recent data also suggest that paternal age also increases the risk of Down Syndrome manifesting in pregnancies in older mothers.[4]
References
- ↑ Sherman SL, Allen EG, Bean LH, Freeman SB (2007). "Epidemiology of Down syndrome". Ment Retard Dev Disabil Res Rev. 13 (3): 221–7. doi:10.1002/mrdd.20157. PMID 17910090.
- ↑ Hook, E.B. (1981). "Rates of chromosomal abnormalities at different maternal ages". Obstet Gynecol. 58: 282. PMID 6455611
- ↑ Estimate from "National Down Syndrome Center". Retrieved 2006-04-21.
- ↑ Warner, Jennifer. "Dad's Age Raises Down Syndrome Risk, Too", "WebMD Medical News". Retrieved 2007-09-29.