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| ==Overview== | | ==Overview== |
| Chronic mountain sickness (CMS) is characterized by [[polycythemia]] (increased [[hematocrit]]) and [[hypoxemia]] which both decrease on descent from altitude. CMS is believed to arise because of an excessive production of [[red blood cell]]s, which increases the oxygen carrying capacity of the blood but may cause increased blood viscosity and uneven blood flow through the lungs ([[V/Q mismatch]]). However, CMS is also considered an adaptation of pulmonary and [[heart disease]] to life under chronic [[hypoxia]] at altitude.<ref name="pmid17072074">{{cite journal| author=Zubieta-Castillo G, Zubieta-Calleja GR, Zubieta-Calleja L| title=Chronic mountain sickness: the reaction of physical disorders to chronic hypoxia. | journal=J Physiol Pharmacol | year= 2006 | volume= 57 Suppl 4 | issue= | pages= 431-42 | pmid=17072074 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17072074 }} </ref> [[Clinical]] diagnosis by laboratory indicators have ranges of: [[Hemoglobin|Hb]] > 200 g/L, [[Hematocrit|Hct]] > 65%, and [[arterial oxygen saturation]] (SaO2) < 85% in both genders.<ref name="pmid20586602">{{cite journal| author=West JB| title=English translation of "Nomenclature, classification, and diagnostic criteria of high altitude disease in China". | journal=High Alt Med Biol | year= 2010 | volume= 11 | issue= 2 | pages= 169-72 | pmid=20586602 | doi=10.1089/ham.2010.1014 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20586602 }} </ref>
| | Laboratory findings consistent with the diagnosis of altitude sickness include increased the level of Hb, Hct and BUN and decreased level of bicarbonate, creatinine and PCO2. |
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| ==Laboratory Findings== | | ==Laboratory Findings== |
Revision as of 15:02, 21 March 2018
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]
Overview
Laboratory findings consistent with the diagnosis of altitude sickness include increased the level of Hb, Hct and BUN and decreased level of bicarbonate, creatinine and PCO2.
Laboratory Findings
- Laboratory findings consistent with the diagnosis of altitude sickness include:[1]
- Increased Hb
- Increased Hct
- Increased BUN
- Decreased bicarbonate
- Decreased creatinine
- Decreased PCO2
References
- ↑ Shah MB, Braude D, Crandall CS, Kwack H, Rabinowitz L, Cumbo TA, Basnyat B, Bhasyal G (2006). "Changes in metabolic and hematologic laboratory values with ascent to altitude and the development of acute mountain sickness in Nepalese pilgrims". Wilderness Environ Med. 17 (3): 171–7. PMID 17078312.
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