Churg-Strauss syndrome pathophysiology: Difference between revisions
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* Pulmonary artery occlusion and thrombus formation. | * Pulmonary artery occlusion and thrombus formation. | ||
* Patchy consolidations of the lung. | * Patchy consolidations of the lung. | ||
* Ventricular hypertrophy, myocardial scariing | * Ventricular hypertrophy, myocardial scariing. | ||
==Microscopic Pathology== | |||
On microscopic examination, following findings can be seen in eosinophilic granulomatosis with polyangiitis, include:<ref name="pmid11743052">{{cite journal |vauthors=Churg A |title=Recent advances in the diagnosis of Churg-Strauss syndrome |journal=Mod. Pathol. |volume=14 |issue=12 |pages=1284–93 |date=December 2001 |pmid=11743052 |doi=10.1038/modpathol.3880475 |url=}}</ref><ref name="pmid11068552">{{cite journal |vauthors=Katzenstein AL |title=Diagnostic features and differential diagnosis of Churg-Strauss syndrome in the lung. A review |journal=Am. J. Clin. Pathol. |volume=114 |issue=5 |pages=767–72 |date=November 2000 |pmid=11068552 |doi=10.1309/F3FW-J8EB-X913-G1RJ |url=}}</ref> | |||
*Infiltration of [[Eosinophil granulocyte|eosinophils]] with [[necrosis]] | |||
*Necrotizing [[vasculitis]] involving small and medium-sized [[Artery|arteries]] and [[Venule|venules]]. | *Necrotizing [[vasculitis]] involving small and medium-sized [[Artery|arteries]] and [[Venule|venules]]. | ||
*Necrotizing [[Granuloma|granulomas]] | *Necrotizing [[Granuloma|granulomas]] | ||
**Interstitial and perivascular necrotizing [[Granuloma|granulomas]] | **Interstitial and perivascular necrotizing [[Granuloma|granulomas]] | ||
**[[Granuloma|Granulomas]] composed of an [[eosinophilic]] center and surrounded by [[Macrophage|macrophages]], [[Histiocyte|histocytes]], and multi nucleated giant cells peripherally. | **[[Granuloma|Granulomas]] composed of an [[eosinophilic]] center and surrounded by [[Macrophage|macrophages]], [[Histiocyte|histocytes]], and multi nucleated giant cells peripherally. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]
Overview
Pathogenesis
The pathogenesis of Eosinophilic granulomatosis with polyangiitis is not fully understood. Eosinophilic granulomatosis with polyangiitis [4] is a medium and small vessel autoimmune vasculitis, leading to necrosis. It involves mainly the blood vessels of the lungs (it begins as a severe type of asthma), gastrointestinal system, and peripheral nerves, but also affects the heart, skin, and kidneys.
Genetics
- HLA-DRB1*7, and HLA-DRB4 are associated with the development of eosinophilic granulomatosis with polyangiitis. HLA-DRB4 is correlated with increasing risk of development of vascular manifestations of the churg-strauss syndrome.[1][2]
- Single-nucleotide polymorphisms in the Interleukin-10 gene (IL10.2 haplotype) have been associated in the pathogenesis of eosinophilic granulomatosis with polyangitis.[3]
Associated Conditions
The following conditions are associated with Eosinophilic granulomatosis with polyangiitis:[4][5][6][7]
- Well's syndrome
- AA amyloidosis
- Asthma
- Nasal polyposis and sinusitis
- Skin
- Cardiovascular:
- Neurologic:
- Renal:
- GI Disease:
Gross Pathology
On gross pathology, the following changes are seen in patients with eosinophilic granulomatosis with polyangiitis include:[8]
- Nodular swellings that appears along the small arteries of various organs
- Heart, liver, kidney, GI tract, and spleen.
- Infarcts, hemorrhage and scarring of affected organs
- Pulmonary artery occlusion and thrombus formation.
- Patchy consolidations of the lung.
- Ventricular hypertrophy, myocardial scariing.
Microscopic Pathology
On microscopic examination, following findings can be seen in eosinophilic granulomatosis with polyangiitis, include:[9][10]
- Infiltration of eosinophils with necrosis
- Necrotizing vasculitis involving small and medium-sized arteries and venules.
- Necrotizing granulomas
- Interstitial and perivascular necrotizing granulomas
- Granulomas composed of an eosinophilic center and surrounded by macrophages, histocytes, and multi nucleated giant cells peripherally.
- Eosinophilic lymphadenopathy
References
- ↑ Vaglio A, Martorana D, Maggiore U, Grasselli C, Zanetti A, Pesci A, Garini G, Manganelli P, Bottero P, Tumiati B, Sinico RA, Savi M, Buzio C, Neri TM (September 2007). "HLA-DRB4 as a genetic risk factor for Churg-Strauss syndrome". Arthritis Rheum. 56 (9): 3159–66. doi:10.1002/art.22834. PMID 17763415.
- ↑ Bottero P, Motta F, Bonini M, Vecchio F, Ierna F, Cuppari I, Sinico RA (2014). "Can HLA-DRB4 Help to Identify Asthmatic Patients at Risk of Churg-Strauss Syndrome?". ISRN Rheumatol. 2014: 843804. doi:10.1155/2014/843804. PMC 3963189. PMID 24734195.
- ↑ Wieczorek S, Hellmich B, Arning L, Moosig F, Lamprecht P, Gross WL, Epplen JT (June 2008). "Functionally relevant variations of the interleukin-10 gene associated with antineutrophil cytoplasmic antibody-negative Churg-Strauss syndrome, but not with Wegener's granulomatosis". Arthritis Rheum. 58 (6): 1839–48. doi:10.1002/art.23496. PMID 18512809.
- ↑ Lee SH, Roh MR, Jee H, Chung KY, Jung JY (2011). "Wells' syndrome associated with churg-strauss syndrome". Ann Dermatol. 23 (4): 497–500. doi:10.5021/ad.2011.23.4.497. PMC 3229945. PMID 22148019.
- ↑ Maamar M, Tazi-Mezalek Z, Harmouche H, El Hamany Z, Adnaoui M, Aouni M (2012). "Churg-Strauss syndrome associated with AA amyloidosis: a case report". Pan Afr Med J. 12: 30. PMC 3415051. PMID 22891088.
- ↑ Neumann T, Manger B, Schmid M, Kroegel C, Hansch A, Kaiser WA, Reinhardt D, Wolf G, Hein G, Mall G, Schett G, Zwerina J (July 2009). "Cardiac involvement in Churg-Strauss syndrome: impact of endomyocarditis". Medicine (Baltimore). 88 (4): 236–43. doi:10.1097/MD.0b013e3181af35a5. PMID 19593229.
- ↑ Chumbley LC, Harrison EG, DeRemee RA (August 1977). "Allergic granulomatosis and angiitis (Churg-Strauss syndrome). Report and analysis of 30 cases". Mayo Clin. Proc. 52 (8): 477–84. PMID 18640.
- ↑ CHURG J, STRAUSS L (1951). "Allergic granulomatosis, allergic angiitis, and periarteritis nodosa". Am J Pathol. 27 (2): 277–301. PMC 1937314. PMID 14819261.
- ↑ Churg A (December 2001). "Recent advances in the diagnosis of Churg-Strauss syndrome". Mod. Pathol. 14 (12): 1284–93. doi:10.1038/modpathol.3880475. PMID 11743052.
- ↑ Katzenstein AL (November 2000). "Diagnostic features and differential diagnosis of Churg-Strauss syndrome in the lung. A review". Am. J. Clin. Pathol. 114 (5): 767–72. doi:10.1309/F3FW-J8EB-X913-G1RJ. PMID 11068552.