Autoimmune hemolytic anemia laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
*'''Tests''' include: | *'''Tests''' include: | ||
:*Direct [[Coombs test]] - | :*Direct [[Coombs' test]]: This is also known at the direct antiglobulin test. This test assesses for the presence of antibodies attached to a patient's [[red blood cells]]. The test is performed by collecting peripheral blood containing [[red blood cells]], which theoretically harbor antibodies in their surface, then adding in a Coombs' reagent and assessing for agglutination. Of note, the Coombs' test can be negative in 3-10% of patients.<ref name="pmid25705656">{{cite journal| author=Berentsen S, Sundic T| title=Red blood cell destruction in autoimmune hemolytic anemia: role of complement and potential new targets for therapy. | journal=Biomed Res Int | year= 2015 | volume= 2015 | issue= | pages= 363278 | pmid=25705656 | doi=10.1155/2015/363278 | pmc=4326213 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25705656 }} </ref> | ||
:*[[Hemoglobin]] in the urine | :*[[Hemoglobin]] in the urine | ||
:*Indirect Coombs' test | :*Indirect Coombs' test | ||
Revision as of 16:47, 31 March 2018
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Autoimmune hemolytic anemia Microchapters |
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Differentiating Autoimmune hemolytic anemia from other Diseases |
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Overview
Laboratory Findings
- Tests include:
- Direct Coombs' test: This is also known at the direct antiglobulin test. This test assesses for the presence of antibodies attached to a patient's red blood cells. The test is performed by collecting peripheral blood containing red blood cells, which theoretically harbor antibodies in their surface, then adding in a Coombs' reagent and assessing for agglutination. Of note, the Coombs' test can be negative in 3-10% of patients.[1]
- Hemoglobin in the urine
- Indirect Coombs' test
- Red blood cell count and serum hemoglobin - anemia
- Reticulocyte count
- Serum bilirubin levels
- Serum haptoglobin
References
- ↑ Berentsen S, Sundic T (2015). "Red blood cell destruction in autoimmune hemolytic anemia: role of complement and potential new targets for therapy". Biomed Res Int. 2015: 363278. doi:10.1155/2015/363278. PMC 4326213. PMID 25705656.