Churg-Strauss syndrome risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chandrakala Yannam, MD [2]

Overview

There are no established risk factors for [disease name].

OR

The most potent risk factor in the development of [disease name] is [risk factor 1]. Other risk factors include [risk factor 2], [risk factor 3], and [risk factor 4].

OR

Common risk factors in the development of [disease name] include [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].

OR

Common risk factors in the development of [disease name] may be occupational, environmental, genetic, and viral.

Risk Factors

• There are no established risk factors for eosinophilic granulomatosis with polyangiitis. However, certain environmental agents including various allergens, infections, desensitization, vaccination, and genetics may act as triggering agents. Those triggers may be responsible for the inflammatory response with eosinophils and lymphocytes.

Common Risk Factors

Common risk factors in the development of eosinophilic granulomatosis with polyangiitis may be various allergens, infections, genetic, and desensitization to drugs and vaccinations.

• Genetic determinants:
  • HLA-DRB1*04 AND *07
  • HLA-DRB4

Interleukin 10 gene single nucleotide polymorphisms

• Allergic agents
• Infections
• Vaccination
• Exposure to silica
• Drugs:
  • Leukotriene receptor antagonists (eg, montelukast, zafirlukast)
  • Anti-IgE antibody (eg,omalizumab)
  • Cocaine
  • Inhaled glucocorticoids
  • Mesalazine
  • Propylthiouracil
  • Methimazole