Henoch-Schönlein purpura causes: Difference between revisions

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==Causes==
==Causes==
*The exact cause of HSP is not clear.  
*The exact cause of HSP is not clear.  
*It may be an abnormal immune system response to infection or an extreme allergic reaction. Other people may be genetically predisposed to developing HSP.
*It may be an inappropriate immune response to triggers such as infection especially upper respiratory infection or an extreme allergic reaction to certain medications, food, insect bites or exposure to cold weather.
*In HSP, the antibodies are directed against the blood vessels causing vasculitis, leading to the leakage, and a subsequent rash.
*In HSP, the antibodies are directed against the blood vessels causing vasculitis, bleeding into the skin leading to a subsequent skin rash.
*Allergic reaction: An extreme allergic reaction to certain foods may cause HSP.
*Allergic reaction to foods may cause HSP.
Genetics: Although rare, HSP occurs in people within the same family, including in twins. This suggests that some cases of HSP may have a genetic cause, although there is no research to prove this.
*Very rarely HSP can occur in twins and within the family.
Other associations: Certain drugs, bacteria, insect bites, viral infections, food, cold weather, and trauma may also cause HSP.
*Certain drugs, bacteria, insect bites, viral infections, food, cold weather, and trauma may also cause HSP.
*Vaccinations- certain vaccines can cause HSP such as Typhoid, HBV, Measles, Yellow fever, and Cholera.


The exact cause of HSP is not known. The body's immune system is believed to play a role in targeting the blood vessels involved. An abnormal immune response to an infection may be a factor in many cases. Approximately two-thirds of the cases of HSP occur days after symptoms of an upper respiratory tract infection develop.
Some cases of HSP have been linked to vaccinations for typhoid, cholera, yellow fever, measles, or hepatitis B; foods, drugs, chemicals, and insect bites. Some experts also say that HSP is associated with the colder weather of fall and winter.
In Henoch-Schonlein purpura, some of the body's small blood vessels become inflamed, which can cause bleeding in the skin, abdomen and kidneys. Why this initial inflammation develops isn't clear. It may be the result of the immune system responding inappropriately to certain triggers.
Nearly half the people who have Henoch-Schonlein purpura developed the disease after an upper respiratory infection, such as a cold. Infectious triggers may include chickenpox, strep throat, measles and hepatitis. Other triggers may include certain medications, food, insect bites or exposure to cold weather


===Causes by Organ System===
===Causes by Organ System===

Revision as of 14:30, 2 April 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Causes

  • The exact cause of HSP is not clear.
  • It may be an inappropriate immune response to triggers such as infection especially upper respiratory infection or an extreme allergic reaction to certain medications, food, insect bites or exposure to cold weather.
  • In HSP, the antibodies are directed against the blood vessels causing vasculitis, bleeding into the skin leading to a subsequent skin rash.
  • Allergic reaction to foods may cause HSP.
  • Very rarely HSP can occur in twins and within the family.
  • Certain drugs, bacteria, insect bites, viral infections, food, cold weather, and trauma may also cause HSP.
  • Vaccinations- certain vaccines can cause HSP such as Typhoid, HBV, Measles, Yellow fever, and Cholera.


Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect Cytarabine , Deferiprone, Ethacrynic Acid, Oxytetracycline
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic No underlying causes
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease No underlying causes
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic No underlying causes
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy No underlying causes
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying causes

Causes in Alphabetical Order

References


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