Sandbox Myopathy: Difference between revisions
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* Signs of glucocorticoid, mineralocorticoid, and, androgen deficiency. | * Signs of glucocorticoid, mineralocorticoid, and, androgen deficiency. | ||
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* Signs of [[postural hypotension]] | |||
* History of [[tuberculosis]] | |||
* History of [[malignancy]] | |||
* History of other [[autoimmune disease]] | |||
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* Hypotension | * Hypotension | ||
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* Milder form of Duchenne | * Milder form of Duchenne | ||
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* Growth delay | |||
* Age of onset of symptoms is much delayed than duchenne | |||
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| colspan="2" | | | colspan="2" | | ||
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** Muscle replacement with fat and connective tissue | ** Muscle replacement with fat and connective tissue | ||
| rowspan="2" | | | rowspan="2" | | ||
* | * Myopathic changes | ||
|- | |- | ||
|Duchenne muscular dystrophy | |Duchenne muscular dystrophy | ||
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* Cognitive impairment | * Cognitive impairment | ||
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* Early onset | |||
* | |||
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* +Grower sign | * +Grower sign |
Revision as of 03:35, 4 April 2018
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Differentiating Various Muscle Weakness
Disease | Symptoms | History | Physical
Examination |
Diagnosis | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Age of onset | Muscle weakness | Fever | Muscle pain | Gait abnormality | Neuropathy | Myoglobinuria | Other features | Laboratory Findings | Creatine Kinase | Muscle Biopsy | Electromyogram | |||||
Proximal | DIstal | |||||||||||||||
Medications | ||||||||||||||||
Corticosteroids |
|
+ | - | - | + | - | - | - |
|
|
|
|
- | - | - | |
Statins |
|
+ | - | - | + | - | - | -/+(rhabdomyolysis) |
|
|
|
|
|
|
- | |
Alcohol |
|
+ | - | - | - | + | +/- | - |
|
|
|
|
|
|
| |
Endocrine | ||||||||||||||||
Cushing's disease |
|
+ | - | - | - | - | - | - |
|
|
|
|
Normal |
|
Normal | |
Adrenal insufficiency |
|
+ | - | - | - | - | - | - |
|
|
|
|
|
|
| |
Hyperaldosteronism with myopathy |
|
+ | + | - | - | - | - | +
Rhabdomyolysis |
|
|
|
|
|
|
| |
Hyperthyroidism |
|
+ | - | - | - | - | - | + |
|
|
|
|
|
|
| |
Hypothyroidism |
|
+ | - | - | + | - | - | + Rhabdomyolysis |
|
|
|
|
|
|
| |
Diabetic infraction |
|
+ | - | + | + | - | + | - |
|
|
|
|
|
|
| |
Inflammatory / Rheumatologic | ||||||||||||||||
Dermatomyositis[1] |
|
+ | - | + | + | - | - | - |
|
|
|
|
|
| ||
Polymyositis[2] |
|
+ | - | + | + | - | - | - |
|
|
|
|
| |||
Inclusion body myositis[3] |
|
+ | + |
|
||||||||||||
Fibomyalgia |
|
+ |
- | - | - | - | ++ | - |
|
|
|
|
|
|
| |
Polymyalgia Rheumatica[4] |
|
+ | - | + | + | - | - | - |
|
|
|
|
|
|
| |
Genetic | ||||||||||||||||
Becker muscular dystrophy | <13yrs | + | - | - | - | + | - | - |
|
|
|
|
|
| ||
Duchenne muscular dystrophy | <13 yrs | + | - | - | - | + | - | - |
|
|
|
|
| |||
Limb-girdle muscular dystrophies | <15 yrs | + | - | - | + | + | - | - |
|
|
|
|
|
|
||
Myotonic dystrophy type 1 | + | + | - | - | + | - | - |
|
||||||||
Infectious | ||||||||||||||||
Lyme disease | Variable | + | - | + | + | +/- | + | - |
|
|
|
|
|
|
| |
Infulenza | Variable | - | - | + | + | + | - | + |
|
|
|
|
|
|
| |
Polio | <5 yrs | + | - | - | - | + | + | - |
|
|
|
|
|
| ||
Syphilis | Variable | - | - | - | - | + | + | - |
|
|
|
|
|
|
| |
Pyomyositis | Variable | +/- | +/- | + | + | - | - | - |
|
|
|
|
|
|
| |
Neurologic | ||||||||||||||||
ALS | ||||||||||||||||
Stroke |
|
+ | + | - | - | + | + | - |
|
|
|
|
|
|
| |
GBS |
|
+ | + | - | - | + | - | - |
|
|
|
|
|
|
| |
Multiple Sclerosis | ||||||||||||||||
Neuro-muscular | ||||||||||||||||
Botulisim | ||||||||||||||||
Lambert-Eaton myaes | ||||||||||||||||
Myasthenia gravis | ||||||||||||||||
Paraneoplastic | ||||||||||||||||
Metabolic | ||||||||||||||||
Glycogen storage disease | ||||||||||||||||
Lipid storage disease | ||||||||||||||||
Mitochondrial |
- ↑ Dalakas MC (1991). "Polymyositis, dermatomyositis and inclusion-body myositis". N Engl J Med. 325 (21): 1487–98. doi:10.1056/NEJM199111213252107. PMID 1658649.
- ↑ Dalakas MC (1991). "Polymyositis, dermatomyositis and inclusion-body myositis". N Engl J Med. 325 (21): 1487–98. doi:10.1056/NEJM199111213252107. PMID 1658649.
- ↑ Dalakas MC (1991). "Polymyositis, dermatomyositis and inclusion-body myositis". N Engl J Med. 325 (21): 1487–98. doi:10.1056/NEJM199111213252107. PMID 1658649.
- ↑ Myklebust G, Gran JT (1996). "A prospective study of 287 patients with polymyalgia rheumatica and temporal arteritis: clinical and laboratory manifestations at onset of disease and at the time of diagnosis". Br J Rheumatol. 35 (11): 1161–8. PMID 8948307.