Rheumatoid arthritis laboratory tests: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
|||
| Line 6: | Line 6: | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
*Diagnosis of rheumatoid arthritis is made with history, physical examination and laboratory test. | |||
*Following tests are used to make the diagnosis: | |||
**Complete blood count with differentials | |||
**Erythrocyte sedimentation rate | |||
**C-reactive protein | |||
**Renal function test | |||
**Liver function test | |||
***[[Rheumatoid factor]] | |||
===Blood tests=== | ===Blood tests=== | ||
: | |||
**When RA is being clinically suspected, [[immunology|immunological]] studies are required, such as [[rheumatoid factor]] (RF, a specific [[antibody]]).<ref>{{cite web | title=Rheumatoid Factor | url=http://www.labtestsonline.org/understanding/analytes/rheumatoid/test.html | work=Lab Tests Online | publisher=American Association for Clinical Chemistry | date=September 30, 2006 | accessdate=2006-10-28}}</ref> | **When RA is being clinically suspected, [[immunology|immunological]] studies are required, such as [[rheumatoid factor]] (RF, a specific [[antibody]]).<ref>{{cite web | title=Rheumatoid Factor | url=http://www.labtestsonline.org/understanding/analytes/rheumatoid/test.html | work=Lab Tests Online | publisher=American Association for Clinical Chemistry | date=September 30, 2006 | accessdate=2006-10-28}}</ref> | ||
**A negative RF does not rule out RA; rather, the arthritis is called ''[[seronegative]]'' | **A negative RF does not rule out RA; rather, the arthritis is called ''[[seronegative]]'' | ||
Revision as of 14:44, 4 April 2018
|
Rheumatoid arthritis Microchapters | |
|
Diagnosis | |
|---|---|
|
Treatment | |
|
Case Studies | |
|
Rheumatoid arthritis laboratory tests On the Web | |
|
American Roentgen Ray Society Images of Rheumatoid arthritis laboratory tests | |
|
Risk calculators and risk factors for Rheumatoid arthritis laboratory tests | |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory Findings
- Diagnosis of rheumatoid arthritis is made with history, physical examination and laboratory test.
- Following tests are used to make the diagnosis:
- Complete blood count with differentials
- Erythrocyte sedimentation rate
- C-reactive protein
- Renal function test
- Liver function test
Blood tests
- When RA is being clinically suspected, immunological studies are required, such as rheumatoid factor (RF, a specific antibody).[1]
- A negative RF does not rule out RA; rather, the arthritis is called seronegative
- During the first year of illness, rheumatoid factor is frequently negative. 80% of patients eventually convert to seropositive status. RF is also seen in other illnesses, like Sjögren's syndrome, and in approximately 10% of the healthy population, therefore the test is not very specific.
- Anti-citrullinated protein:
- Because of this low specificity, a new serological test has been developed in recent years, which tests for the presence of so called anti-citrullinated protein antibodies (ACPA).
- Like RF, this test can detect approximately 80% of all RA patients, but is rarely positive in non-RA patients, giving it a specificity of around 98%. In addition, ACP antibodies can be often detected in early stages of the disease, or even before disease onset. Currently, the most common test for ACP antibodies is the anti-CCP (cyclic citrullinated peptide) test.[2]
- ESR and CRP:
- Also, several other blood tests are usually done to allow for other causes of arthritis, such as lupus erythematosus. The erythrocyte sedimentation rate (ESR), C-reactive protein,[3] full blood count, renal function, liver enzymes and other immunological tests (e.g. antinuclear antibody/ANA)[4] are all performed at this stage. Ferritin can reveal hemochromatosis, which can mimic RA.
References
- ↑ "Rheumatoid Factor". Lab Tests Online. American Association for Clinical Chemistry. September 30, 2006. Retrieved 2006-10-28.
- ↑ "CCP (Cyclic Citrullinated Peptide antibody)". Lab Tests Online. American Association for Clinical Chemistry. January 15, 2005. Retrieved 2006-10-28.
- ↑ "C-Reactive Protein". Lab Tests Online. American Association for Clinical Chemistry. September 3, 2004. Retrieved 2006-10-28.
- ↑ "ANA (Antinuclear Antibody)". Lab Tests Online. American Association for Clinical Chemistry. December 13, 2004. Retrieved 2006-10-28.