Polymyositis and dermatomyositis laboratory findings: Difference between revisions
| Line 24: | Line 24: | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
* | *Different laboratory tests may be used to diagnose polymyositis and dermatomyositis which include:<ref name="pmid29579414">{{cite journal |vauthors=Adler BL, Christopher-Stine L |title=Triggers of inflammatory myopathy: insights into pathogenesis |journal=Discov Med |volume=25 |issue=136 |pages=75–83 |date=February 2018 |pmid=29579414 |doi= |url=}}</ref> | ||
**Sarcoplasmic enzymes | |||
**Myositis-specific autoantibodies | |||
** | |||
=== Sarcoplasmic enzymes === | === Sarcoplasmic enzymes === | ||
* Sarcoplasmic enzymes consistent with the diagnosis of polymyositis and dermatomyositis include: | * Sarcoplasmic enzymes consistent with the diagnosis of polymyositis and dermatomyositis include: | ||
Revision as of 16:08, 5 April 2018
|
Polymyositis and dermatomyositis Microchapters |
|
Differentiating Polymyositis and dermatomyositis from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Polymyositis and dermatomyositis laboratory findings On the Web |
|
American Roentgen Ray Society Images of Polymyositis and dermatomyositis laboratory findings |
|
Polymyositis and dermatomyositis laboratory findings in the news |
|
Blogs on Polymyositis and dermatomyositis laboratory findings |
|
Risk calculators and risk factors for Polymyositis and dermatomyositis laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]
Overview
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
OR
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].
OR
[Test] is usually normal for patients with [disease name].
OR
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].
OR
There are no diagnostic laboratory findings associated with [disease name].
Laboratory Findings
- Different laboratory tests may be used to diagnose polymyositis and dermatomyositis which include:[1]
- Sarcoplasmic enzymes
- Myositis-specific autoantibodies
Sarcoplasmic enzymes
- Sarcoplasmic enzymes consistent with the diagnosis of polymyositis and dermatomyositis include:
- Creatine phosphokinase
- Aldolase
- Transaminases
- Lactic dehydrogenase
Myositis-specific autoantibodies
| Autoantibody | Association | Percentage |
|---|---|---|
| Histidyl-tRNA synthetase (anti-Jo-1) |
|
|
| Chromodomain helicase DNA binding protein 4 (Mi-2) |
|
|
| Signal recognition particle (anti-SRP) |
|
|
| Alanyl-tRNA synthetase (PL-12) |
|
|
| Transcriptional intermediary factor 1-gamma (TIF-1γ) |
|
|
| Nuclear matrix protein (NXP-2) |
|
|
| Anti-small ubiquitin-like modifier activating enzyme (anti-SAE) |
|
|
| Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) |
|
6% |